International Journal of Drug Delivery Technology
Volume 14, Issue 1

Formulation, In-vitro and In-vivo Evaluation of Chronology-based Mucoadhesive Drug Delivery System of an Antihypertensive Drug

Bhagyesh U Janugade*, Neelam Singla

School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India. 

Received: 28th July, 2023; Revised: 03rd December 2023; Accepted: 12th February, 2024; Available Online: 25th March, 2024

ABSTRACT

Current research aimed to prepare and estimate chronology-based mucoadhesive PDDS of antihypertensive drug losartan potassium through formulation of fast-dissolving core tablet and incorporation of core tablet to polymer coating to formulate bioadhesive PDDS through direct compression system. The coating was done by using polymers ethyl cellulose and carbopol 934. Pre-compression and post-compression parameters, drug release, lag time and mucoadhesive examination was assessed for the formulation. The expected lag time for hypertension is 8 hours; hence, this lag time was achieved by using a bioadhesive pulsatile system. The optimized formulation showed 8 hours lag time with appropriate mucoadhesion for an equivalent period. Moreover, in-vitro as well as in-vivo mucoadhesion investigations reflected the positive outcomes. Consequently, the BPDDS was the finest preventative substitute for drugs with the highest absorption in the stomach and for drugs used to treat diseases related to circadian rhythm.

Keywords: Mucoadhesive drug delivery system, Losartan potassium, Lag time, Circadian rhythm, Bioadhesion, Drug release. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.14

How to cite this article: Janugade BU, Singla N. Formulation, In-vitro and In-vivo Evaluation of Chronology-based Mucoadhesive Drug Delivery System of an Antihypertensive Drug. International Journal of Drug Delivery Technology. 2024;14(1):94-101.

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