International Journal of Drug Delivery Technology
Volume 14, Issue 1

Formulation Development and Evaluation of Montelukast Sodium Paper Tablets for Enhanced Drug Release

Patil Pavan*, Mane Preeti, Wakure Balaji

Vilasrao Deshmukh Foundation, Group of Institutions, VDF School of Pharmacy, Latur, Maharashtra, India. 

Received: 05th July, 2023; Revised: 31st January, 2024; Accepted: 29th February, 2024; Available Online: 25th March, 2024

ABSTRACT

In this study, the technique of paper-based tablets was evaluated for solubility enhancement of montelukast sodium (MS), an anti-asthmatic, Biopharmaceutical Classification System (BCS) class II medication. Initially, the potential for compressing regular paper into tablets was rigorously examined. Results demonstrated that paper may be utilised to make tablets, regardless of type of the paper utilized. The medicinal quality was satisfactory; and entire tablets of the batch met the Indian Pharmacopeia’s criteria. Compressing drug-loaded paper resulted in the formation of drug-loaded tablets. The MS loaded tablets prepared using kitchen roll paper delivered the best results. The tablet was disintegrated in 27 seconds, and drug release of MS was enhanced by 1.88 folds. The tablets were sufficiently hard, and they did not get broken during friability studies. Also, the tablets passed the other evaluation parameters. These paper tablets were also stable under accelerated storage conditions.

Keywords: Montelukast sodium, Paper tablets, Solubility, Disintegration, In-vitro dissolution. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.15

How to cite this article: Pavan P, Preeti M, Balaji W. Formulation Development and Evaluation of Montelukast Sodium Paper Tablets for Enhanced Drug Release. International Journal of Drug Delivery Technology. 2024;14(1):102-108.

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