International Journal of Drug Delivery Technology
Volume 14, Issue 1

Fast Dissolving Tablets of Promethazine Theoclate: Optimization by Box Behnken Design

Rama D Korni1, Kamala KPV2*, V Sahiti2

1Department of Pharmaceutical Technology, Raghu College of Pharmacy, Visakhapatnam, Andhra Pradesh, India.

2Department of Pharmaceutics, Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, Andhra Pradesh, India. 

Received: 10th September, 2023; Revised: 01st January, 2024; Accepted: 14th February, 2024; Available Online: 25th March, 2024

ABSTRACT

The current work was planned to optimize promethazine theoclate fast-dissolving tablets using Box Behnken design. The effect of three independent factors, the concentration of camphor (sublimating agent), sodium starch glycolate (superdisintegrant) and β-cyclodextrin (solubility enhancer) on two responses, disintegration time and percent drug release was studied. A total of 27 formulations were prepared and tested for various precompression and postcompression parameters. The correlation between factors and responses was established by plotting contour plots. The independent variables, the concentration of camphor and sodium starch glycolate, have a significant influence on response disintegration time, whereas the factor, concentration of β-cyclodextrin, has an effect on the response and percent drug release.

Keywords: Sublimation, Box-Behnken design, Contour plots, Optimization.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.18

How to cite this article: Korni RD, Kamala KPV, Sahiti V. Fast Dissolving Tablets of Promethazine Theoclate: Optimization by Box Behnken Design. International Journal of Drug Delivery Technology. 2024;14(1):126-131.

REFERENCES

  1. Rahane RD, Rachh A review on fast dissolving tablet. Journal of Drug Delivery and Therapeutics. 2018;8(5):50-55.
  2. Vishali T, Damodharan. Orodispersible Tablets: A Review. Research JPharm andTech.July-Sept. 2008;1(3):218-224.
  3. Lewis GA (2002) Optimization methods In: Swabrick J and Boylan JC (Eds.) Encyclopedia of Pharmaceutical Technology 2 edn. Marcel Dekker., New York, pp. 1922-1937.
  4. Myers WR (2003) Response surface methodology In: Chow SC (Ed) Encyclopedia of Biopharmaceutical Statisticians. Marcel Dekker inc., New York, pp. 858-869.
  5. Box GEP and Behnken Some new three-level designs for the study of quantitative variables. Technometrics. 1960;2:455-475.
  6. Brunton L, Chabner B, Knollman B. Goodman and Gilman’s the Pharmacological Basis of Therapeutics. 10th ed. NewYork: McGraw Hill; 2006. pp. 1031-1036.
  7. Gregory RE, Ettinger DS. 5-HT3 receptor antagonists for the prevention of chemotherapy-induced nausea and vomiting: A comparison of their pharmacology and clinical efficacy. Drugs. 1998 Feb;55(2):173-89.
  8. Prashant Kumar, Akhilesh Tiwari, Gulshan Chhabra, Kamla Use of central composite design for statistical optimization promethazine theoclate-loaded solid lipid nanoparticles. Asian Journal of Pharmaceutics. October-December 2014;8(4):279-286.
  9. Myers RH, MontgomeryD C, Vining GG, BorrorCM,KowalskiSM. Response surface methodology: a retrospective and literature survey. Journal of Quality Technology. 2004;36(1):53-77.
  10. Comparison between method of one-factor- at-a-time (OFAT) & design of experiment (DOE) in screening of immunoglobulin production stimulating factors (Doctoral dissertation, Universiti Malaysia Pahang). 2010.
  11. Indian Pharmacopoeia 2022 Volume I The Indian Pharmacopoeia Commmision Ghaziabad p. 360.
  12. Indian Pharmacopoeia 2022 Volume I The Indian Pharmacopoeia Commmision Ghaziabad p. 365.
  13. Kumari PVK, YarraguntlaSR, SharmilaM, GulibindalaE. (2021). Application of Box-Behnken Design for Formulation Parameters of Eslicarbazepine Tablets. Indian Journal of Pharmaceutical Sciences. 2021;83(3):575-583.