International Journal of Drug Delivery Technology
Volume 14, Issue 1

Morin Hydrate Mediated Biosynthesis of Silver Nanoparticles and Its Antimicrobial Activity

Nanthakumar Ramalingam1*, Prabakaran Venkatachalam2, V Vinodhkumar1, C Vichitra1

1Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, India.

2 Novitium Pharma LLC, East Windsor, New Jersey, USA. 

Received: 09th July, 2023; Revised: 31st January, 2024; Accepted: 29th February, 2024; Available Online: 25th March, 2024

ABSTRACT

Morin hydrate is a flavonoid that is chosen as an active ingredient for synthesizing silver nanoparticles. In order to characterize the morin hydrate assisted silver nanoparticles (MHNP), field emission scanning electron microscopy (FE-SEM), ultraviolet- visible spectrophotometry, energy dispersive X-ray spectroscopy (EDAX), dynamic light scattering analyzer (DLS) was used, and inductively coupled plasma-optical emission spectroscopy (ICP-OES) studies were used to determine the total amount of silver contained in the liquid state of the MHNP. Then, the formed nanoparticles were evaluated for antimicrobial effect. In the UV-visible spectroscopy, maximum absorption was observed at 444.5 nm, which is characteristic of silver nanoparticles. According to FE-SEM data, the generated nanoparticles were spherical, and DLS analysis determined that the average particle size was 83.4 nm. EDAX images additionally proved that silver was present in the sample. The antibacterial studies revealed that the nanoparticles were effective only against certain gram-positive bacterial strains; therefore, they can be used in biomedical applications, especially for treating infections caused by gram-positive bacteria.

Keywords: Morin hydrate, Silver nanoparticles, Antimicrobial activity.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.20

How to cite this article: Ramalingam N, Venkatachalam P, Vinodhkumar V, Vichitra C. Morin Hydrate Mediated Biosynthesis of Silver Nanoparticles and Its Antimicrobial Activity. International Journal of Drug Delivery Technology. 2024;14(1):140-144.

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