International Journal of Drug Delivery Technology
Volume 14, Issue 1

Preparation and Evaluation of Polyherbal Periodontal Gel for Treatment of Periodontitis

NG Raghavendra Rao1, Desu Brahma Srinivasa Rao2, Parag A Kulkarni3, Dhruv Dev4, G Santhana Kumar5*

1Kiet School of Pharmacy, Kiet Group of Institutions, Ghaziabad, Uttar Pradesh, India.

2Department of Pharmacology, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India.

3Shastry Institute of Pharmacy, Erandol, Jalgaon Maharashtra, India.

4Shivalik College of Pharmacy, Maujowal, Punjab, India.

5Faculty of Pharmacy, Marwadi University, Rajkot, Gujarat, India. 

Received: 23rd July, 2023; Revised: 08th September, 2023; Accepted: 17th February, 2024; Available Online: 25th March, 2024

ABSTRACT

Periodontal disease is one of the most important concerns for dentists and patients. The study aimed to create a topical polyherbal gel using ethanolic extract and to evaluate polyherbal gel. Ethanolic extract of Curcuma longa rhizomes, chamomile powder from Matricaria chamomilla, and clove oil were obtained and used to prepare different formulations of polyherbal gels using hydroxypropyl methylcellulose (HPMC) and other excipients. The prepared gel formulations were studied for pH, viscosity and spreadability evaluation. The pH was observed to be in between 6 to 7 and had ideal viscosity and spreadability range. The drug content and in-vitro drug release profile were evaluated and plotted to identify optimized gel formulations among all prepared formulations. The optimized polyherbal formulation, F2, was applied to field emission scanning electron microscopy (FESEM). The antimicrobial evaluation showed that the prepared formulations are effective in inhibiting microbial growth and effective in periodontal care.

Keywords: Periodontitis lesions, Flora, Herbal extracts, Periodontal gel, Evaluations. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.26

How to cite this article: Rao NGR, Rao DBS, Kulkarni PA, Dev D, Kumar GS. Preparation and Evaluation of Polyherbal Periodontal Gel for Treatment of Periodontitis. International Journal of Drug Delivery Technology. 2024;14(1):179-182.

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