International Journal of Drug Delivery Technology
Volume 14, Issue 1

Formulation and Evaluation of Natural Excipient-based Mucoadhesive Salbutamol Sulphate Tablets

Rathi PC1* Biyani KR2

1Department of Pharmaceutics, Sant Gadge Baba Amravati University, Buldhana Maharashtra, India.

2Department of Pharmacology, Sant Gadge Baba Amravati University, Buldhana Maharashtra, India.

Received: 21st August, 2023; Revised: 13th October, 2023; Accepted: 09th March, 2024; Available Online: 25th March, 2024

ABSTRACT

When creating a mucoadhesive sustained-release formulation for oral consumption, aquaphilic matrices are a captivating option to consider. These aquaphilic matrices are used to release water-soluble and water-insoluble drugs. Gums and mucilages used in the current study are linseed mucilage (LM) and tamarind seed polysaccharide (TSP). The present work aims to focus on the possibilities of using these polysaccharides to prepare a new medication delivery system. The aim of the research was to make a salbutamol sulfate mucoadhesive tablet for the treatment of asthma. The wet granulation method was adopted for the formulation of the salbutamol sulfate mucosal adhesive tablet. Mucosal adhesive tablets were assessed for multiple parameters. The drug release is low as the amount of gums and mucilages is high. A mucoadhesive tablet containing linseed mucilage and chitosan exhibits good mucoadhesive performance and in-vitro drug release. Optimized formulation FM1 fits the Higuchi plot of release kinetics.

Keywords: Salbutamol sulfate, Mucoadhesive, Linseed mucilage, Chitosan, Asthma, Tamarind seed polysaccharide. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.28

How to cite this article: Rathi PC, Biyani KR. Formulation and Evaluation of Natural Excipient-based Mucoadhesive Salbutamol Sulphate Tablets. International Journal of Drug Delivery Technology. 2024;14(1):188-197.

REFERENCES

  1. Bonferoni MC, Rossi S, Tamayo M, Pedraz JL, Dominguez- Gil A, Caramella On the employment of λ-carrageenan in a matrix system. I. Sensitivity to dissolution medium and comparison with Na carboxymethylcellulose and xanthan gum. Journal of controlled release. 1993 Aug 1;26(2):119-127.
  2. Mali KK, Dhawale SC, Dias RJ, Ghorpade Delivery of drugs using tamarind gum and modified tamarind gum: A review. Bulletin of Faculty of Pharmacy, Cairo University. 2019 Jun 1;57(1):1-24. https://doi.org/10.21608/BFPC.2019.47260
  3. Jani GK, Shah DP, Prajapati VD, Jain Gums and mucilages: versatile excipients for pharmaceutical formulations. Asian Journal of Pharmaceutical Sciences. 2009;4(5):309-23.
  4. Monif T, Malhotra AK, Kapoor VP. Cassia fistula seed galactomannan: Potential binding agent for pharmaceutical formulation. Indian Journal of Pharmaceutical Sciences. 1992;54:234-240
  5. Mylangam CK, Beeravelli S, Medikonda J, Pidaparthi JS, Kolapalli VR. Badam gum: a natural polymer in mucoadhesive drug delivery. Design, optimization, and biopharmaceutical evaluation of badam gum-based metoprolol succinate buccoadhesive Drug delivery. 2016 Jan 2;23(1):195-206. doi: 10.3109/10717544.2014.908979.
  6. Baveja SK, Gupta BM. Rheology of Aqueous dispersions of Plantago ovata seed husk-II. Indian Journal of Pharmaceutical Sciences. 1968;30(1):247-251.
  7. Zhou P, Eid M, Xiong W, Ren C, Ai T, Deng Z, Li J, Li B. Comparative study between cold and hot water extracted polysaccharides from Plantago ovata seed husk by using rheological Food Hydrocolloids. 2020 Apr 1;101:105465. https://doi.org/10.1016/j.foodhyd.2019.105465
  8. Mithal BM, Kasid Evaluation of emulsifying properties of Plantago ovata (Ispaghula) seed husk. Indian Journal of Pharmaceutical Sciences. 1964;26:316-319.
  9. Mithal BM, Kasid JL. Evaluation of the suspending properties of Plantago ovata (Ispaghula) seed husk. Indian Journal of Pharmaceutical Sciences. 1965;27(1):331-315.
  10. Madan M, Bajaj A, Lewis S, Udupa N, Baig In situ forming polymeric drug delivery systems. Indian journal of pharmaceutical sciences. 2009 May;71(3):242-251. doi: 10.4103/0250-474X.56015
  11. Nirmal HB, Bakliwal SR, Pawar SP. In-Situ gel: New trends in Controlled and Sustaineded Drug Delivery International Journal of Pharm Tech Research. 2010; 2(2):1398-1408.
  12. Taylor M, Paul T, Sahota Thermoresponsive gels. Gels 2017; 3(4): 1-31. Taylor M, Paul T, Sahota T. Thermoresponsive gels. Gels 2017; 3(4): 1-31. https://doi.org/10.3390/gels3010004
  13. Kumar N, Pahuja S, Sharma R. Pharmaceutical Polymers: A Review. 2019; 9(1); 27-33. DOI:10.25258/ijddt.9.1.5
  14. Indian Pharmacopoeia, Government of India, Ministry of Health and Family Welfare, Controller of Publication, New Delhi, 2007; vol-1:36-37.
  15. Pelczer MJ, Chan ECS, Krieg Microbiology Tata MC Graw Hill, 5th ed., 2009; 128-129.
  16. Koocheki A, Mortazavi SA, Shahidi F, Razavi SM, Taherian AR. Rheological properties of mucilage extracted from Alyssum homolocarpum seed as a new source of thickening Journal of food engineering. 2009 Apr 1;91(3):490-496. DOI:10.1016/j. jfoodeng.2008.09.028
  17. Annisa R, Yuwono M, Hendradi Effect of vegetable oil on self- nanoemulsifying drug delivery system of dayak onion [Eleutherine palmifolia (L.) Merr.] extract using hydrophilic-lipophilic balance approach: formulation, characterization. International Journal of Drug Delivery Technology. 2020;10(2):210-216. DOI: 10.25258/ ijddt.10.2.4.
  18. Sharjel L, Andrew BCY. Applied Biopharmaceutics and Pharmacokinetics, 4th Prentice Hall International, New York. 1999; 437.
  19. Al-Tamimi DJ, Hussien AA. Preparation and In-vitro Characterization of Tacrolimus as a Solid Self-micro-emulsion. International Journal of Drug Delivery 2021;11(1):70-DOI: 10.25258/ijddt.11.1.12.
  20. Nyavanandi D, Narala S, Mandati P, Alzahrani A, Kolimi P, Almotairy A, Repka MA. Twin Screw Melt Granulation: Alternative Approach for Improving Solubility and Permeability of a Non-steroidal Anti-inflammatory Drug Ibuprofen. AAPS PharmSciTech. 2023;24(1):47.
  21. Park SH, Chun MK, Choi Preparation of an extended-release matrix tablet using chitosan/Carbopol interpolymer complex. International journal of pharmaceutics. 2008 Jan 22;347(1-2):39-https://doi.org/10.1016/j.ijpharm.2007.06.024
  22. Nakano M, Kouketsu M, Nakamura Y, Juni Sustained release of sulfamethizole from agar beads after oral administration to humans. Chemical and Pharmaceutical Bulletin. 1980 Oct 25;28(10):2905-2908. doi: 10.1248/cpb.28.2905.
  23. Butreddy A, Sarabu S, Almutairi M, Ajjarapu S, Kolimi P, Bandari S, Repka MA. Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions: Impact of polymeric combinations on supersaturation kinetics and dissolution performance. International Journal of 2022 Mar 5;615:121471. https://doi.org/10.1016/j. ijpharm.2022.121471
  24. Higuchi Mechanism of sustained‐action medication.Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. Journal of pharmaceutical sciences. 1963 Dec;52(12):1145-1149. https://doi.org/10.1002/jps.2600521210
  25. Kuksal A, Tiwary AK, Jain NK, Jain Formulation and in-vitro , in vivo evaluation of extended-release matrix tablet of zidovudine: influence of combination of hydrophilic and hydrophobic matrix formers. AAPS pharmscitech. 2006 Mar;7:E1-E9. doi: 10.1208/pt070101
  26. Ameena K, Dilip C, Saraswathi R, Krishnan PN, Sankar C, Simi Isolation of the mucilages from Hibiscus rosasinensislinn. and Okra (Abelmoschus esculentuslinn.) and studies of the binding effects of the mucilages. Asian Pacific Journal of Tropical Medicine, 2010; 539-543. https://doi.org/10.1016/S1995-7645(10)60130-7
  27. Chavan GM, Devineni J, Dev D, Shirode AR, Minhas PS. Formulation Development of Mucoadhesive Tablets for the treatment of Hypertension using Losartan International Journal of Drug Delivery Technology, 2023; 13(4): 1483-1488. DOI: 10.25258/ijddt.13.4.55
  28. Chanda R, Nath LK, Mahapatra Formulation Development of Oral Mucoadhesive Coated Terbutaline Sulphate Tablets Using Some Natural MaterialsExtracted from Edible Fruits Available in India: Formulation of oral mucoadhesive terbutaline tablets. Iranian Journal of Pharmaceutical Sciences. 2009 Jan 1;5(1):3-12.
  29. Narala S, Komanduri N, Nyavanandi D, Youssef AA, Mandati P, Alzahrani A, Kolimi P, Narala N, Repka MA. Hard gelatin capsules containing hot melt extruded solid crystal suspension of carbamazepine for improving dissolution: Preparation and in-vitro Journal of Drug Delivery Science and Technology. 2023 Apr 1; 82:104384. DOI: https://doi. org/10.1016/j.jddst.2023.104384
  30. Indian Pharmacopoeia. Controller of publications, Delhi, India. 2007; Vol-II, p. 241-243, 736.