International Journal of Drug Delivery Technology
Volume 14, Issue 1

Development and Optimization of Eperisone Hydrochloride Microcapsule

Vijay Sharma1, Charanjeet Singh1*, Anil K Gupta2, Yashwant3

1Goenka College of Pharmacy, Lachhmangarh, Sikar, Rajasthan, India

2Jaipur College of Pharmacy, Jaipur, Rajasthan, India

3R.S. Memorial College of Pharmacy, Panipat, Haryana, India

Received: 15th October, 2023; Revised: 20th December, 2023; Accepted: 10th February, 2024; Available Online: 25th March, 2024

ABSTRACT

The main objective of the work is to develop the microcapsule of eperisone hydrochloride. In the investigation, a 23-factorial design were was employed for the optimization process and to investigate the effect of Eudragit® RS100 concentration in the coating solution (X1), the speed of rotation (X2) and the concentration of plasticizer (PEG 400) (X3) on the release rate of the drug from the microcapsules. The extent of coating (Y1), and the percentage of drug released at 1 (Y2), 6 (Y3) and 12 hours (Y4) were selected as dependent variables. Optimized microcapsules of eperisone hydrochloride follow the zero-order kinetics that a promising controlled release of the highly water soluble drug and was successfully designed for further formulation.

Keywords: Eperisone HCl, Ion exchange resins, Amberchrom, Factorial design, Optimization. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.34

How to cite this article: Sharma V, Singh C, Gupta AK, Yashwant. Development and Optimization of Eperisone Hydrochloride Microcapsule. International Journal of Drug Delivery Technology. 2024;14(1):230-235.

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