International Journal of Drug Delivery Technology
Volume 14, Issue 1

Network Pharmacology and Molecular Docking Technology-based Strategy to Explore the Potential Mechanism of Diabecon Formulation Botanicals

Vijay Sable*, Ganesh Ahire

Department of Pharmaceutical Sciences, Sunrise University, Alwar, Rajasthan, India. 

Received: 10th August, 2023; Revised: 11th January, 2024; Accepted: 16th March, 2024; Available Online: 25th March, 2024

ABSTRACT

This study presents network pharmacology and a molecular docking-centered approach to elucidate the possible mechanism of action underlying the therapeutic effects of diabecon, a formulation containing Gymnema sylvestre, Pterocarpus marsupium, and Asphaltum punjabinum botanicals. Through comprehensive bioinformatics analysis, a collection of bioactive compounds present in these botanicals was identified, and their potential targets were forecasted using Swiss Target Prediction and STITCH. Disease-related genes were retrieved from Genecards and OMIM, and common genes between potential targets and disease- related genes were determined. Pathway analysis using the DAVID database revealed significant enrichment in pathways related to metabolic processes, xenobiotic metabolism, and signaling pathways, such as the insulin signaling pathway and pathways in cancer. Network construction using cytoscape highlighted interactions among identified genes, providing insights into the molecular pathways modulated by diabecon. Molecular docking analysis further elucidated the possible connections amongst biologically active compounds and target proteins, with (2S)-7-hydroxyflavanone exhibiting strong binding affinity with DPP-IV enzyme. Overall, this integrated approach offers valuable insights into the potential mechanisms of action of diabecon, contributing to our understanding of its therapeutic effects in the management of diabetes mellitus.

Keywords: Network pharmacology, Molecular docking, Diabecon formulation, Gymnema sylvestre, Pterocarpus marsupium, Asphaltum punjabinum, Bioactive compounds, Pathway analysis, Target prediction, Disease-related genes, Insulin signaling pathway, Diabetes mellitus.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.39

How to cite this article: Sable V, Ahire G. Network Pharmacology and Molecular Docking Technology-based Strategy to Explore the Potential Mechanism of Diabecon Formulation Botanicals. International Journal of Drug Delivery Technology. 2024;14(1):274-280.

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