International Journal of Drug Delivery Technology
Volume 14, Issue 1

Development and Evaluation of Venlafaxine Hydrochloride Tablets for Oral Drug Delivery Technology

Vijay Sable, Sanjay Wagh

Department of Pharmaceutical Sciences, Sunrise University, Alwar, Rajasthan, India. 

Received: 15th November, 2023; Revised: 28th December, 2023; Accepted: 14th January, 2024; Available Online: 25th March, 2024

ABSTRACT

Oral pills are the predominant, simple, and straightforward approach for administering drugs. The project’s primary goal is to create a pharmaceutical product that is equal in terms of its medicinal properties. A controlled-release version of the antidepressant venlafaxine hydrochloride was created and compared to the formulation currently available on the market. The launch of the branded product was assessed through an innovator and prototype evaluation. In order to develop stable and bioavailable dosage forms, it is necessary to gather pertinent data through preformulation testing. In order to create stable and bioavailable dosage forms, preformulation testing must be performed to gather relevant information among the several mixes, high-performance polymer copolymer K100M, ethyl cellulose, and cross-linked polyvinyl pyrrolidone 0.45%. The precise release mechanism could be determined by conducting in-vitro solubility tests on the created formulations and analyzing the results with a number of exponential equations. We used fourier-transform infrared (FTIR) and differential scanning calorimetry (DSC) studies to check if the polymers were compatible with the medicine.

Keywords: Oral drug delivery, Venlafaxine hydrochloride, Dissolution testing, Analysis. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.42

How to cite this article: Sable V, Wagh S. Development and Evaluation of Venlafaxine Hydrochloride Tablets for Oral Drug Delivery Technology. International Journal of Drug Delivery Technology. 2024;14(1):293-298.

REFERENCES

  1. Mujawar T, Ahmad S, Tajane P, Sable V, Gaikwad A, Tare H. Development and validation of ultraviolet spectrophotometric method for Saquinavir estimation in bulk and dosage form. Multidisciplinary Science Journal. 2023 Apr 9;5(2):2023020.
  2. Kharate V, Kuchekar M, Harde M, Pimple B, Patole V, Salunkhe M, Wadgave P, Bhise M, GaikwadA, Tare H. Development of Validated Stability Indicating HPTLC Method for Estimation of Febuxostat in Bulk and TabletDosage Form by Using QBD Approach. International Journal of Drug Delivery Technology. 2023;13(2):542-550.
  3. Barde L, Suruse P, Agrawal S, Kalkotwar R, Sable V, Tare H. Design, Development And Fabrication Of Mouth-Dissolving Tablets Containing Extract of Tribulus terrestris for the Treatment of Int J App Pharm. 2023;15(3):234-41.
  4. Senthilnathan B, Rupenagunta Formulation development and evaluation of venlafaxine hydrochloride orodispersible tablets. International Journal of Pharmaceutical Sciences and Research. 2011 Apr 1;2(4):913.
  5. Maddiboyina B, Jhawat V, Sivaraman G, Sunnapu O, Nakkala RK, Naik MH, Gulia M. Formulation development and characterization of controlled release core-in-cup matrix tablets of venlafaxine HCl. Current Drug Therapy. 2020 Oct 1;15(5):503-11.
  6. Patel J. Evaluation and Development of Osmotic drug delivery of venlafaxine Hydrochloride Asian Journal of Pharmaceutical Research. 2013;3(2):89-97.
  7. Mannan A, Rao Novel chewable tablet-in-tablet dosage form of Orlistat and Venlafaxine hydrochloride: development and evaluation. Journal of Applied Pharmaceutical Science. 2015 Mar 28;5(3):091-7.
  8. Chauhan V, Nizami T, Rathore N, Malviya N. Formulation and evaluation of sublingual tablet of Venlafaxine hydrochloride for the treatment of depression. Journal of Drug Delivery and Therapeutics. 2019 Apr 24;9(2-A):56-8.
  9. Sandhya P, Durani HZ, Majeed Z, Ganesh Kumar Formulation and in vitro evaluation of sustained release tablets of venlafaxine hydrochloride by porous osmotic technology. Int J Sci Res Public. 2014;4:1-8.
  10. Swain S, Behera A, Dinda SC, Patra CN, Jammula S, Beg S, Rao Formulation design, optimization and pharmacodynamic evaluation of sustained release mucoadhesive microcapsules of venlafaxine HCl. Indian Journal of Pharmaceutical Sciences. 2014 Jul;76(4):354.
  11. Al-Mogherah AI, Ibrahim MA, Hassan MA. Optimization and evaluation of venlafaxine hydrochloride fast dissolving oral Saudi pharmaceutical journal. 2020 Nov 1;28(11):1374-82.
  12. Nagaraj K, Kumar M, Bhanja S, Mishra P, Sudhakar M. Formulation, Optimisation And In Vitro Evaluation Of Mouth Dissolvingtablets Of Venlafaxine Hydrochloride. International Journal Of Pharmacy And Pharmaceutical Sciences. 2013;5:246-
  13. Poongothai S, Srinivasan R, Rama A Correlative Dissolution Study of Oral Drug DeliverySystems through Reverse Phase- HPLC Analysis. International Journal of Pharmaceutical Quality Assurance. 2023;14(3):553-558.
  14. Wagh VT, Gilhotra RM, Wagh Solid Dispersion (Kneading) Technique: A Platform forEnhancement Dissolution Rate of Valsartan Poorly Water Soluble Drug. International Journal of Pharmaceutical QualityAssurance. 2020;11(1):20-24.
  15. Ahmad S, Patil K, Koli G, Rahman BA, Barde L, Deshpande M, Tare Design, Development andCharacterization of Econazole loaded Nanoparticles for Topical Application. International Journal of Pharmaceutical QualityAssurance. 2023;14(2):358- 362.