International Journal of Drug Delivery Technology
Volume 14, Issue 1

Evaluating the Efficacy of Tetracycline Local Drug Delivery in Managing Oral Lesions Caused by Pathogens: A Comparative Study

Hina Ahmed1, Shekhar Gupta2, Bharti Gupta3, Dipooja Patil4*

1Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia.

2Department of Prosthodontic Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabi.

3Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia. 4Department of Conservative Dentistry and Endodontics Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, Maharashtra, India. 

Received: 06th January, 2024; Revised: 05th February, 2024; Accepted: 25th February, 2024; Available Online: 25th March, 2024

ABSTRACT

Background: Oral lesions caused by pathogens represent a significant clinical challenge, necessitating effective management strategies. Due to its antimicrobial properties, tetracycline local drug delivery has shown promise in combating such lesions. This study aims to evaluate the efficacy of tetracycline local drug delivery compared to conventional treatments in managing oral lesions caused by pathogens.

Materials and Methods: A comparative study was conducted involving 100 patients diagnosed with oral lesions attributable to pathogenic infections. Patients were randomly assigned to either the tetracycline local drug delivery group or the conventional treatment group. The tetracycline group received locally administered tetracycline, while the conventional group received standard treatments such as antiseptic mouthwashes or topical corticosteroids. Lesion size, pain scores, and microbial load were assessed at baseline and after four weeks of treatment.

Results: In the tetracycline local drug delivery group, the mean reduction in lesion size was 50%, compared to 30% in the conventional treatment group (p < 0.05). Pain scores decreased significantly in both groups, with a greater reduction observed in the tetracycline group (p < 0.01). Microbial load showed a significant decrease in the tetracycline group compared to the conventional group (p < 0.001).

Conclusion: Tetracycline local drug delivery demonstrates superior efficacy in managing oral lesions caused by pathogens compared to conventional treatments. It significantly reduces lesion size, pain scores, and microbial load. Incorporating tetracycline local drug delivery into clinical practice could offer a more effective approach to treating such oral lesions.

Keywords: Oral lesions, tetracycline, local drug delivery, pathogens, antimicrobial, comparative study, International. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.51

How to cite this article: Ahmed H, Gupta S, Gupta B, Patil D. Evaluating the Efficacy of Tetracycline Local Drug Delivery in Managing Oral Lesions Caused by Pathogens: A Comparative Study. International Journal of Drug Delivery Technology. 2024;14(1):357-359.

REFERENCES

  1. Scully C, el-Kabir M, Samaranayake LP. Candida and oral candidosis: a Crit Rev Oral Biol Med. 1994;5(2):125-157.
  2. Akpan A, Morgan R. Oral candidiasis. Postgrad Med J. 2002;78(922):455-459.
  3. Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012;27(6):409-419.
  4. Slots J. Herpesviral-bacterial interactions in periodontal diseases. Periodontol 2000. 2010;52(1):117-140.
  5. Nair RG, Samaranayake The effect of oral hygiene regimens on the plaque and gingival indices and microbial counts of salivary lactobacilli and Streptococci in orthodontic patients. Aust Dent J. 1991;36(2):102-107.
  6. Akpan A, Morgan R. Oral candidiasis. Postgrad Med J. 2002;78(922):455-459.
  7. Patini R, Cattani P, Marchetti S, Isola G, Quaranta G, Gallenzi
  8. Evaluation of Antimicrobial Efficacy of Tetracycline-Based Scaffolds in Patients with Periodontal Disease: A Systematic Review. Antibiotics (Basel). 2020;9(8):490.
  9. Golub LM, Ramamurthy NS, McNamara TF, Greenwald RA, Rifkin Tetracyclines inhibit tissue collagenase activity. A new mechanism in the treatment of periodontal disease. J Periodontal Res. 1984;19(6):651-655.
  10. Eber RM, Ylostalo PV, Chuang SK, et al. Tetracycline labeling for detection of periodontal pathogens: in vitro J Periodontol. 2000;71(12):1873-1881.
  11. Bhavsar NV, Joshi CP. Efficacy of Tetracycline in Local Drug Delivery System versus Conventional Mechanical Therapy in the Treatment of Chronic Periodontitis: A Comparative J Int Oral Health. 2015;7(5):62-65.
  12. González-Moles MA, Bravo M, Ruiz-Avila I, Ramos-García Local chemotherapy with tetracycline-loaded polymethylmethacrylate carriers in patients with oral squamous cell carcinoma: a clinical pilot study. Oral Oncol. 2007;43(3):275-280.)