International Journal of Drug Delivery Technology
Volume 14, Issue 1

Development and Validation of Stability Indicating UV Spectrophotometric Method for Estimation of Resveratrol in Bulk and Tablet Dosage Form

Parag Pathade*, Anjali Sumrao, Bhushan Sonawane, Dhanshree Shirode, Sagar Shewale, Vaishnavi Shinde, Vinod Bairagi

Department of Pharmaceutical Chemistry, KBHSS Trust’s Institute of Pharmacy, Nashik, Maharashtra, India. 

Received: 19th August, 2023; Revised: 24th October, 2023; Accepted: 24th February, 2024; Available Online: 25th March, 2024

ABSTRACT

A simple, sensitive, accurate, trustworthy, and stable UV spectrophotometric approach has been devised to quantify resveratrol in pharmaceutical formulations and bulk materials. After scanning the UV spectrum from 200 to 400 nm, the highest wavelength for absorption was determined to be 306 nm. For the medication, Beer’s rule has been adhered to within a concentration range of 1 to 5 µg/mL. While the developed method was able to recover a good amount of drug (%Recovery), the precision study’s percentage RSD values were ≥2%. The method demonstrated effective functionality for a pharmaceutical dosage form containing resveratrol, free from interference from the excipients. Correspondingly, the limit of detection (LoD) for resveratrol were 0.13 and 0.40 µg/mL. The results of this investigation have been confirmed in accordance with ICH standards. Research on artificial degradation has been greenlit, which investigates the impacts of several environmental factors over a broad pH spectrum, including heat, oxidation, photolysis, and hydrolysis vulnerability.

Keywords: UV spectrophotometric, Resveratrol, Forced deterioration, ICH norms

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.56

How to cite this article: Pathade P, Sumrao A, Sonawane B, Shirode D, Shewale S, Shinde V, Bairagi V. Development and Validation of Stability Indicating UV Spectrophotometric Method for Estimation of Resveratrol in Bulk and Tablet Dosage Form. International Journal of Drug Delivery Technology. 2024;14(1):385-388.

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