International Journal of Drug Delivery Technology
Volume 14, Issue 1

Formulation and Evaluation of Lipid-based Nanoformulation of Itraconazole

Amit Sinhal1*, Rajendra Wagh2

1Department of Pharmaceutics, Prof. Ravindra Nikam College of Pharmacy, Gondur, Dhule, Affiliated to Kavayitri

Bahinabai Chaudhari North Maharashtra University, Jalgaon, Maharashtra, India.

2Department of Pharmaceutical Chemistry, ARA College of Pharmacy, Nagaon, Dhule, Affiliated to Kavayitri Bahinabai

Chaudhari North Maharashtra University, Jalgaon, Maharashtra, India. 

Received: 10th November, 2023; Revised: 26th January, 2024; Accepted: 05th February, 2024; Available Online: 25th March, 2024

ABSTRACT

The powdered form of itraconazole is white, flavorless, and stable, but it dissolves slowly in water. In comparison to palmitic acid, stearic acid has a stronger affinity (2.57), as shown by the partition coefficient test. UV-visible spectra analysis reveals critical compound insights. Fourier-transform infrared (FTIR) identifies significant peaks in itraconazole and related compounds. tween 80 is selected for solid lipid nanoparticles (SLN) based on their appearance. Optimization using 0.5% w/v tween 80 yielded better particle capture. Thermal analyses display distinctive characteristics of itraconazole, palmitic acid, and polyvinyl alcohol. Viscosity studies mirror tear film behavior. Transmission electron microscope (TEM) images demonstrate SLN’s potential ocular application without irritation. Antifungal studies exhibit effective inhibition of Candida albicans and Aspergillus flavus growth. SN-7 reveals strong encapsulation efficiency, mean vesicle size, and sustained drug release over 12 hours. Pharmacokinetic studies shed light on SLNs’ influence on drug absorption and distribution, indicative of potential in drug delivery systems. These findings offer promising prospects in formulating enhanced drug delivery mechanisms and understanding their impact on drug pharmacokinetics. High-performance liquid chromatography (HPLC) analysis confirmed SN-7’s singular peak at 6.59 minutes. Both formulations showcased skin penetration and stability over three months under varied conditions. Skin irritation tests on rats indicated minimal reactions, affirming low irritancy, which is crucial for patient comfort and acceptance in topical drug delivery. These assessments ensure safety and effectiveness in treating fungal infections.

Keywords: Solid lipid nanoparticles, FTIR analysis, Skin irritation test.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.61

How to cite this article: Sinhal A, Wagh R. Formulation and Evaluation of Lipid-based Nanoformulation of Itraconazole. International Journal of Drug Delivery Technology. 2024;14(1):417-428.

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