International Journal of Drug Delivery Technology
Volume 14, Issue 1

Nanotechnology-based Intranasal Drug Delivery Systems: A Review

Shiv C Prajapati1*, Sunita Singh2, Bhupendra Singh3, Mukul Sengar4, Vinay Mishra4

1Department of Paint Technology, Government Polytechnic Bindki, Fatehpur, Uttar Pradesh, India.

2Department of Pharmacy, Ambekeshwar Institute of Pharmaceutical Sciences, Lucknow, Uttar Pradesh, India.

3Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.

4Department of Chemical Engineering, Institute of Engineering and Technology, Lucknow, Uttar Pradesh, India. 

Received: 02nd September, 2023; Revised: 24th January, 2024; Accepted: 06th February, 2024; Available Online: 25th March, 2024

ABSTRACT

An experimental study has focused on developing a different approach to systemic oral along with parenteral administration in order to overcome their common drawbacks, including hepatic first-pass, which reduces drug bioavailability following oral administration, off-target effects, low patient compliance, along with a slow onset of pharmacological action through first-aid cases. Novel drug delivery systems (DDS), mostly composed of polymers and biocompatible lipid materials, have significantly boosted this sector in recent years. The previously intranasal (IN) method of delivery is an acceptable non-invasive option. It is ideal for self-administration since the medication quickly enters the circulation, eliminating the initial pass effect, and it may additionally reach the brain’s cortex directly by crossing the blood-brain barrier (BBB). The combination of the IN route alongside DDS can, therefore, become a successful method for regulated drug administration, particularly when a rapid impact is sought or required. This study seeks to analyze the scientific literature on IN-DDS and its various routes for consumption (systemic, topical, pulmonary, and nose-to-brain). In this regard, the intranasal route offers a viable pathway for medication delivery reaching the brain because of its distinct anatomical characteristics. Nanoparticle-based technologies, in particular, have proven a remarkable ability to overcome the limitations of the intranasal route to induce drug accumulation throughout the brain despite avoiding systemic dissemination.

Keywords: Novel drug delivery systems, Intranasal, Advantages, Nanotechnology and Methods. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.66

How to cite this article: Prajapati SC, Singh S, Singh B, Sengar M, Mishra V. Nanotechnology-based Intranasal Drug Delivery Systems: A Review. International Journal of Drug Delivery Technology. 2024;14(1):472-480.

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