International Journal of Drug Delivery Technology
Volume 14, Issue 1

Study of Oxidative Stress and Inflammatory Status in Thyroid Dysfunction: A Systematic Review

Bushra*, Sangeeta Kapoor, Tariq Mahmood

Department of Biochemistry, Teerthanker Mahaveer Medical College and Research Centre, Uttar Pradesh, India. 

Received: 20th December, 2023; Revised: 21st January, 2024; Accepted: 22nd February, 2024; Available Online: 25th March, 2024

ABSTRACT

Background: The frequency of thyroid disorders is rising quickly, making them a major socioeconomic issue. Oxidative stress is also connected to thyroid disorders with increasing frequency. Moreover, an association between underlying inflammatory processes and oxidative damage must be considered because most thyroid ailments are seen to have an underlying inflammatory basis.

Aim & objectives: This systematic review assesses the oxidative stress in thyroid dysfunctions and their association with inflammatory processes.

Methodology: A systematic review of the literature was done using databases that included- PubMed, Scopus, Science Direct, Research Gate and Google Scholar using the keywords “oxidative stress”, “inflammatory markers,” and “thyroid disorders” from 2000-2022. After separately evaluating citations and abstracts, two reviewers examined full-text publications and came to an agreement on the research that should be included. We conducted this research using the preferred reporting items for systematic research and meta-analysis (PRISMA).

Results: A total of 531 articles were found, out of which only 51 met the criteria of inclusion. A significant heterogeneity across the studies was found. In these studies, various oxidant/antioxidant and inflammatory markers were used to determine oxidative stress and its association with inflammatory processes. Most studies found a high level of reactive oxygen species (ROS) induced by an imbalance of thyroid hormones that can cause oxidative stress with a consequent lipid peroxidation response and accelerated inflammatory response.

Conclusion: Data from the literature demonstrated a significant correlation between oxidative damage results and elevated ROS production. Thyroid issues can potentially trigger or exacerbate oxidative stress and ROS generation, which can worsen oxidative damage. Additionally, recent research indicates that OS and inflammation may be related in some way since mitochondrial reactive species are signalling molecules that cause the release of proinflammatory cytokines.

Keywords: Thyroid dysfunction, Oxidative stress, Inflammatory markers, Antioxidants. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.71

How to cite this article: Bushra, Kapoor S, Mahmood T. Study of Oxidative Stress and Inflammatory Status in Thyroid Dysfunction: A Systematic Review. International Journal of Drug Delivery Technology. 2024;14(1):515-522.

REFERENCES

  1. Anandkumar S, Chacko J, Theertha K, Usha M. Thyroid Disorder: An Overview. Res. J. Pharmacology and Pharmacodynamics. 2020; 12(1): 1-4.
  2. Kim Thyroid hormone as a determinant of energy expenditureand the basal metabolic rate. Thyroid. 2008; 18(2): 141-4.
  3. Lancaster J.R. Nitric oxide in cells. American Scientist. 1992; 80(2): 249–59.
  4. Cross R. and Jones O.T.G. Enzymic mechanism of superoxyde production. Biochimica and Biophysica Acta. 1991; 1057(1): 281–4.
  5. Ohye H and Sugawara Dual oxidase, hydrogen peroxide and thyroid diseases. Experimental Biology and Medicine. 2010; 235(4): 424–33.
  6. Varela, Rivolta C.M., Esperante S.A., Papendieck L.G., Chiesa A., and Targovnik H.M. Three mutations in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect. Clinical Chemistry. 2006; 52(2): 182– 91.
  7. Poncin S, Gérard C., Boucquey M, Senou M, Calderon P.B., Knoops B, et al. Oxidative Stress in the Thyroid Gland: From Harmlessness to Hazard Depending on the Iodine Content. Endocrinology. 2008; 149(1): 424–33.
  8. Mutaku JF, Poma JF, Many MC, Denef JF, van Den Hove MF. Cell necrosis and apoptosis are differentially regulated during goitre development and iodine-induced J Endocrinol. 2002; 172(2) :375-86. doi: 10.1677/joe.0.1720375.
  9. Kochman J, Jakubczyk K, Bargiel P, Janda-Milczarek K. The Influence of Oxidative Stress on Thyroid Diseases. Antioxidants. 2021; 10(9) :1442.
  10. Mancini A, Di Segni C, Raimondo S, Olivieri G, Silvestrini A, Meucci E, Currò D. Thyroid Hormones, Oxidative Stress, and Inflammation. Mediators Inflamm. 2016: 6757154. doi: 1155/2016/6757154.
  11. Williams MS and Kwon J. T cell receptor stimulation, reactive oxygen species and cell signaling. Free Radical Biology and Medicine. 2004; 37(2): 1144–51.
  12. Eddib I, Barhoumi L, Mahmoudi A, Ben Nasr Oxidative stressin thyroid dysfunction. Endocrinol Metab Int J. 2022;10(2):66-69
  13. Roshni R, Prabhu A, Rao Y. D, Sowndarya K, Nandini Assessment of Oxidative Stress Index in Sub-clinical Hypothyroidism. Biomed Pharmacol J. 2021;14(2)
  14. Kochman J, Jakubczyk K, Bargiel P, Janda-Milczarek K. The Influence of Oxidative Stress on Thyroid Antioxidants (Basel). 2021;10(9):1442.
  15. Sultana DR, Shahin AD, Md Jawadul H. Measurement of oxidative stress and total antioxidant capacity in hyperthyroid patients following treatment with carbimazole and antioxidant. Heliyon. 2021;8(1):e08651.
  16. Szczepanik J, Podgórski T, Domaszewska The Level of Zinc, Copper and Antioxidant Status in the Blood Serum of Women with Hashimoto’s Thyroiditis. Int J Environ Res Public Health. 2021;18(15):7805.
  17. Sankha S, Kumar YM, Madhuri AA, Kumar Antioxidant status and oxidative stress in hypothyroidism. J Datta Meghe Inst Med Sci Univ. 2021;16:508-14.
  18. Mahmood AS, Awad M, Mohymen NA. Effect of Unbalanced in Oxidative Stress And Antioxidant Status on RBCs Membranes In Thyroid Disorders Patients. PalArch’s Journal of Archaeology of Egypt / Egyptology. 2022;17(7):7623-31.
  19. Rabbani E, Golgiri F, Janani L, Moradi N, Fallah S, Abiri B, Vafa Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism. Biol Trace Elem Res. 2021;199(11):4074-83.
  20. Ates I, Arikan MF, Altay M, Yilmaz FM, Yilmaz N, Berker D, Guler S. The effect of oxidative stress on the progression of Hashimoto’s thyroiditis. Arch Physiol Biochem. 2018;124(4):351-
  21. Kalpana, K.Kayalvizhi. Study of Bio-Chemical Status on Antioxidants, Lipid Profiles and Minerals in Hypothyroidism. International Journal of Chem Tech Research, 2017,10(3): 238-5.2
  22. Hamed A. Deraz, Amira Shoukry, Hoda G. Bakr. Lipid Peroxidation and Antioxidant Status in Overt and Subclinical Hypothyroidism. Int J Advan Res. 2016; 6(5): 22-9
  23. Kaur A, Kaur J, Kukreja S, Sharma A, Neha. Total antioxidant status and serum lipid profile in hypothyroid patients in tertiary care hospital of Northern International Journal of Clinical Biochemistry and Research. 2016;3(3):259-61
  24. Ates I, Yilmaz FM, Altay M, Yilmaz N, Berker D, Güler S. The relationship between oxidative stress and autoimmunity in Hashimoto’s thyroiditis. Eur J Endocrinol. 2015;173(6):791-9.
  25. Baser H, Can U, Baser S, Yerlikaya FH, Aslan U, Hidayetoglu BT. Assesment of Oxidative Status and Its Association with Thyroid Autoantibodies in Patients with Euthyroid Autoimmune Thyroiditis. 2015; 48:916–923
  26. Cheserek MJ, Wu GR, Ntazinda A, Shi YH, Shen LY, Le GW. Association Between Thyroid Hormones, Lipids and Oxidative Stress Markers in Subclinical J Med Biochem. 2015;34(3):323-31.
  27. Naazeri S, Rostamian M, Hedayati M. Impact of Thyroid Dysfunction on Antioxidant Capacity, Superoxide Dismutase and Catalase Zahedan J Res Med Sci. 2014; 16(1): 51-4.
  28. Haribabu A, Reddy VS, Pallavi Ch, Bitla AR, Sachan A, Pullaiah P, Suresh V, Rao PV, Suchitra MM. Evaluation of protein oxidation and its association with lipid peroxidation and thyrotropin levels in overt and subclinical hypothyroidism. Endocrine. 2013;44(1):152-7.
  29. Reddy VS, Gouroju S, Suchitra MM et al., “Antioxidant defense in overt and subclinical hypothyroidism,” Hormone and Metabolic Research. 2013; 45(10): 754–8.
  30. Rostami R, Aghasi MR, Mohammadi A, Nourooz-Zadeh J. Enhanced oxidative stress in Hashimoto’s thyroiditis: inter- relationships to biomarkers of thyroid function. Clin Biochem. 2013 ;46(4-5):308-12.
  31. Cebeci E, Alibaz-Oner F, Usta M, Yurdakul S, Erguney M. Evaluation of oxidative stress, the activities of paraoxonase and arylesterase in patients with subclinical Journal of Investigative Medicine. 2012;60:23–28.
  32. Santi A, Duarte MM, de Menezes CC, Loro VL. Association of lipids with oxidative stress biomarkers in subclinical hypothyroidism. Int J Endocrinol. 2012;2012:856359.
  33. Naazeri S, Rostamian M, Hedayati Impact of thyroid dysfunction on Antioxidant Capacity, Superoxide dismutase and Catalase activity. Zahedan Journal of Research in Medical Sciences. 2012;16(1): 51-54.
  34. Haribabu A, Reddy VS, Pallavi Ch, Bitla AR, Sachan A, Pullaiah P, Suresh V, Rao PV, Suchitra MM. Evaluation of protein oxidation and its association with lipid peroxidation and thyrotropin levels in overt and subclinical hypothyroidism. Endocrine. 2013;44(1):152-7.
  35. Wang D, Feng JF, Zeng P, Yang YH, Luo J, Yang YW. Total oxidant/antioxidant status in sera of patients with thyroid Endocr Relat Cancer. 2011 Dec 1;18(6):773-82
  36. Santi A, Duarte MM, Moresco RN, Menezes C, Bagatini MD, Schetinger MR, Loro VL. Association between thyroid hormones, lipids and oxidative stress biomarkers in overt hypothyroidism. Clin Chem Lab Med. 2010;48(11):1635-9.
  37. Torun AN, Kulaksizoglu S, Kulaksizoglu M, Pamuk O, Isbilen E, Tutuncu N.B. Serum Total Antioxidant Status and Lipid Peroxidation Marker Malondialdehyde Levels in Overt and Subclinical Hypothyroidism. Clin. Endocrinol. 2009; 70: 469–74.
  38. Coria MJ, Pastrán AI, Gimenez MS. Serum oxidative stress parameters of women with Acta Biomed. 2009;80(2): 135-9
  39. Erdaman H, Demirci H, Yaman H, Erbil MK, Yakar T, Sancak B, et al. The effect of hypothyroidism, hyperthyroidism and their treatment on parameters of oxidative stress and antioxidant status. Clin Chem Lab Med. 2008; 46(7): 1004-10.
  40. Baskol G, Atmaca H, Tanriverdi F, Baskol M, Kocer D and Bayram Oxidative stress and enzymatic antioxidant status in patients with hypothyroidism before and after treatment. Experimental and Clinical Endocrinology & Diabetes. 2007; 115(8): 522–6.
  41. Venditti P and Di Meo S. Thyroid hormone-induced oxidative Cellular and Molecular Life Sciences. 2006; 63(4): 414–34.
  42. Lampka M, Junik R, Nowicka A, Kopczyńska E, Tyrakowski T, Odrowaz-Sypniewska G. Oxidative stress markers during a course of Endokrynol Pol. 2006;57(3):218-22.
  43. Suzan S. Rustam and Bushra F. Hassan. Assessment of inflammatory marker (Hs-CRP and OPN) and other parameters in Hypothyroidism. Teikyo Med J. 2021; 44(6): 99-108
  44. Khaled A, EL-Hefnawy, Elsaid HH. Assessment of some inflammatory markers and lipid profile as risk factors for atherosclerosis in subclinical hypothyroid The Egyptian journal of internal medicine. 2019; 31(2):115–21
  45. Ahmed N, Nagtilak S, Sharma K, Parashar P, Rastogi A. Role of circulating C Reactive protein in thyroid disorders. J of Med Sci Clin Res. 2018; 6(2). 485-9
  46. Savas E, Sahin AZ, Aksoy SN, Tascan A, Sayiner AZ, Ozkaya Serum levels of inflammatory markers in patients with thyroid dysfunction and their association with autoimmunity status. Int J Clin Exp Med. 2016; 9(2): 4485-90.
  47. Marchiori RC, Pereira LA, Naujorks AA, Rovaris DL, Meinerz DF, Duarte MM, Rocha JB. Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine BMC Endocr Disord. 2015;15:32.
  48. Gupta G, Sharma P, Kumar P, Itagappa Study on Subclinical Hypothyroidism and its Association with Various Inflammatory Markers. J Clin Diagn Res. 2015;9(11):BC04-6.
  49. Kale MK, Bhusari KP, Umathe S.N. Role of thyroid hormones in the generation of widespread oxidative stress. J Cell Tissue Res. 2007; (1): 871-6.
  50. Efe H, Kirci D, Deger O, et al. Erythrocyte antioxidant enzyme activities and lipid peroxidation in patients with types IIb and IV Tohoku J Exp Med. 2004; 202(3): 163-72.
  51. Sripad DV, Chowdary NVS, Sivaprabodh V, Shekhar R. Oxidative stress in thyroid dysfunction. International journal of current medical and applied sciences. 2014; 5(1): 31-5.
  52. Mohan KKM, Lobby Z,Selvaraj N, Kumar Possible link between glycated hemoglobin and lipid peroxidation in hyperthyroidism. Clin Chem Acta. 2019; 342: 187-92.
  53. Komosinska-Vassev K, Olczyk K, Kucharz EJ, et Free radical activity and antioxidant defense mechanisms in patients with hyperthyroidism due to Graves’ disease during therapy. Clin Chim Acta. 2000; 300(1-2): 107-17.
  54. Segal BH, Grimm MJ, Khan AN, Han W, Blackwell TS. Regulation of innate immunity by NADPH Free Radical Biology & Medicine. 2012; 53: 72–80.
  55. Mancini A, Raimondo S, Di Segni C, Persano M, and Pontecorvi Non-thyroidal illness: physiopathology and clinical implications,” in Current Topics in Hypothyroidism with Focus on Development, E. Potlukova, Ed., pp. 183–202, InTech, Rijeka, Croatia, 2013.
  56. Cachefo A, Boucher P, Vidon C, Dusserre E, Diraison F, Beylot Hepatic lipogenesis and cholesterol synthesis in hyperthyroid patients. J Clin Endocrinol Metab. 2001; 86(11): 5353-7.
  57. Rizos CV, Elisaf MS, Liberopoulos EN. Effects of thyroid dysfunction on lipid profile. Open Cardiovasc Med J. 2011; 5: 76-84.