International Journal of Drug Delivery Technology
Volume 14, Issue 1

Revolutionizing Medicine: Advances in Polymeric Drug Delivery Systems

Rahul Bijwar, Harshal Tare

Faculty of Pharmacy, Oriental University, Indore, Madhya Pradesh, India

Received: 26th November, 2023; Revised: 30th December, 2023; Accepted: 20th January, 2024; Available Online: 25th March, 2024

ABSTRACT

Polymeric drug delivery systems have emerged as a transformative force in modern medicine, reshaping the landscape of drug delivery and patient care. This review article comprehensively explores the advancements and innovations that have propelled polymeric drug delivery systems to the forefront of medical research and practice. Beginning with a historical perspective, we trace the evolution of drug delivery systems, highlighting the pivotal role played by polymers in this journey. We delve into the diverse array of polymeric drug delivery systems, ranging from nanoparticles and hydrogels to implantable devices and polymer-drug conjugates, elucidating their unique characteristics and applications. A critical focus of this review lies in the criteria governing polymer selection, including biocompatibility, biodegradability, and drug-loading capabilities. We illuminate the remarkable impact of polymeric drug delivery systems across various medical domains, including oncology, central nervous system disorders, cardiovascular diseases, infectious diseases, and chronic conditions. Furthermore, we explore recent breakthroughs, such as smart polymers for responsive drug release and nanotechnology-driven precision medicine, which are revolutionizing patient care. Clinical success stories and FDA-approved polymeric drug delivery systems underscore the tangible benefits these innovations bring to patients. Despite these remarkable achievements, challenges and future directions are also examined, addressing regulatory considerations, scalability issues, and the integration of emerging technologies. We conclude by emphasizing the transformative potential of polymeric drug delivery systems and call for sustained research and development efforts to harness their full capabilities. This review illuminates the dynamic and promising future of polymeric drug delivery systems in revolutionizing medicine and advancing the frontiers of patient-centric care.

Keywords: Polymeric drug delivery systems, Drug delivery, Nanoparticles, Hydrogels, Implantable devices, Polymer drug conjugates, Biocompatibility, Biodegradability, Precision medicine, Clinical applications, Smart polymers, Nanotechnology, FDA-approved, Transformative, Challenges, Future directions, Patient-centric care.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.78

How to cite this article: Bijwar R, Tare H. Revolutionizing Medicine: Advances in Polymeric Drug Delivery Systems. International Journal of Drug Delivery Technology. 2024;14(1):572-580.

REFERENCES

  1. Ezike TC, Okpala US, Onoja UL, Nwike PC, Ezeako EC, Okpara JO, Okoroafor CC, Eze SC, Kalu OL, Odoh EC, Nwadike U. Advances in drug delivery systems, challenges and future directions. Heliyon. 2023 Jun 24.
  2. Jindal AB, Bhide AR, Salave S, Rana D, Benival Long-acting parenteral drug delivery systems for the treatment of chronic diseases. Advanced Drug Delivery Reviews. 2023 May 7:114862.
  3. Liu R, Luo C, Pang Z, Zhang J, Ruan S, Wu M, Wang L, Sun T, Li N, Han L, Shi J. Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment. Chinese chemical letters. 2023 Feb 1;34(2):107518.
  4. Sang W, Zhang R, Shi X, Dai Advanced Metallized Nanofibers for Biomedical Applications. Advanced Science. 2023 Aug 2:2302044.
  5. Pires PC, Mascarenhas-Melo F, Pedrosa K, Lopes D, Lopes J, Macário-Soares A, Peixoto D, Giram PS, Veiga F, Paiva- Santos Polymer-based biomaterials for pharmaceutical and biomedical applications: A focus on topical drug administration. European Polymer Journal. 2023 Feb 1:111868.
  6. Hemmrich E, McNeil S. Active ingredient vs excipient debate for nanomedicines. Nature Nanotechnology. 2023 Apr 27:1-4.
  7. Zhang Y, Chen J, Shi L, Ma F. Polymeric nanoparticle-based nanovaccines for cancer immunotherapy. Materials Horizons.Naief MF, Mohammed SN, Mayouf HJ, Mohammed AM. A review of the Role of Carbon Nanotubes for Cancer Treatment Based on Photothermal and Photodynamic Therapy Journal of Organometallic Chemistry. 2023 Jul 20:122819.
  8. Saxena S, Bhardwaj S, Aggarwal A. Brain Targeted Drug Delivery System: A Review. Research and Analysis Journal. 2023 Jun 27;6(6):16-29.
  9. Nicolas J, Pivato CA, Chiarito M, Beerkens F, Cao D, Mehran
  10. Evolution of drug-eluting coronary stents: a back-and-forth journey from the bench to bedside. Cardiovascular Research. 2023 Mar 1;119(3):631-46.
  11. Pandya A, Vora L, Umeyor C, Surve D, Patel A, Biswas S, Patel K, Patravale Polymeric in situ forming depots for long-acting drug delivery systems. Advanced Drug Delivery Reviews. 2023 Jul 6:115003.
  12. Jafernik K, Ładniak A, Blicharska E, Czarnek K, Ekiert H, Wiącek AE, Szopa A. Chitosan-Based Nanoparticles as Effective Drug Delivery Systems—A review. Molecules. 2023 Feb 18;28(4):1963.
  13. Walvekar P, Kumar P, Choonara YE. Long-acting vaccine delivery Advanced Drug Delivery Reviews. 2023 May 22:114897.
  14. Yu Z, Shen X, Yu H, Tu H, Chittasupho C, Zhao Smart Polymeric Nanoparticles in Cancer Immunotherapy. Pharmaceutics. 2023 Feb 26;15(3):775.
  15. Metawea OR, Teleb M, Haiba NS, Elzoghby AO, Khafaga AF, Noreldin AE, Khattab SN, Khalil Folic acid-poly (N-isopropylacrylamide-maltodextrin) nanohydrogels as novel thermo-/pH-responsive polymer for resveratrol breast cancer targeted therapy. European Polymer Journal. 2023 Jan 3;182:111721.
  16. Yang Z, Gao D, Zhao J, Yang G, Guo M, Wang Y, Ren X, Kim JS, Jin L, Tian Z, Zhang X. Thermal immuno-nanomedicine in Nature Reviews Clinical Oncology. 2023 Feb;20(2):116-34.
  17. Chen M, Lan H, Jin K, Chen Y. Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future Drug Delivery. 2023 Dec 31;30(1):2219427.
  18. Skepu A, Phakathi B, Makgoka M, Mbita Z, Damane BP, Demetriou D, Dlamini Z. AI and Nanomedicine in Realizing the Goal of Precision Medicine: Tailoring the Best Treatmentfor Personalized Cancer Treatment. InArtificial Intelligence and Precision Oncology: Bridging Cancer Research and Clinical Decision Support 2023 Jan 21 (pp. 181-194). Cham: Springer Nature Switzerland.
  19. Jiang L, Wu J. Emerging ultrasonic bioelectronics for personalized healthcare. Progress in Materials Science. 2023 Mar 7:101110.
  20. Wu H, Zhang T, Li N, Gao Cell membrane-based biomimetic vehicles for effective central nervous system target delivery: Insights and challenges. Journal of Controlled Release. 2023 Aug 1;360:169-84.
  21. Duan L, Li X, Ji R, Hao Z, Kong M, Wen X, Guan F, Ma S. Nanoparticle-Based Drug Delivery Systems: An Inspiring Therapeutic Strategy for Neurodegenerative Polymers. 2023 May 5;15(9):2196.
  22. Salave S, Rana D, Sharma A, Bharathi K, Gupta R, Khode S, Benival D, Kommineni N. Polysaccharide based implantable drug delivery: Development strategies, regulatory requirements, and future Polysaccharides. 2022 Sep 8;3(3):625-54.
  23. Bhat AA, Nisar S, Mukherjee S, Saha N, Yarravarapu N, Lone SN, Masoodi T, Chauhan R, Maacha S, Bagga P, Dhawan P. Integration of CRISPR/Cas9 with artificial intelligence for improved cancer therapeutics. Journal of Translational Medicine. 2022 Nov 18;20(1):534.
  24. Alshawwa SZ, Kassem AA, Farid RM, Mostafa SK, Labib GS. Nanocarrier drug delivery systems: characterization, limitations, future perspectives and implementation of artificial Pharmaceutics. 2022 Apr 18;14(4):883.