International Journal of Drug Delivery Technology
Volume 14, Issue 1

Auxiliary Substances for Enhancement of Complexation Efficiency and Dissolution Rate of Drug-Cyclodextrin Complexes

Priya Patil1*, Subhash Kumbhar1, Vishwajeet Ghorpade2

1School of Pharmaceutical Sciences, Sanjay Ghodawat University, Atigre, Kolhapur, Maharashtra, India.

2KIMSDU’s Krishna Institute of Pharmacy, Karad, Maharashtra, India.

Received: 12th January, 2024; Revised: 18th February, 2024; Accepted: 10th March, 2024; Available Online: 25th March, 2024

ABSTRACT

Background: Enzymatic starch breakdown yields 1, 4-linked D-glucopyranoside subunits, which are the building blocks of the cyclodextrin (CD) family of macromolecules. β-Cyclodetrins (β-CDs) have the capability to improve the solubility of partially soluble drugs, as well as their permeability across biological membranes and stability. However, factors like limited solubility, high cost of derivatives and their toxicity at high concentrations has directed the researchers toward multicomponent inclusion complexes (MCIC).

Introduction: Incorporating auxiliary substances (AS) leads to MCIC formation during complexation. The auxiliary agent interacts at the molecular level with the CDs, enhances the complexation competence of β-CD or its derivatives, and minimizes the amount required for solubilization of poorly soluble drugs. They also enhance stability of drug-CD complex. Due to these advantages, the popularity of MCIC has increased amongst formulation scientists.

Conclusion: This review describes various AS that could be used to prepare MCIC to expand solubility and other properties

of drugs and minimize cost of related formulation.

Keywords: Cyclodextrin, Solubility, Multicomponent inclusion complex, Bioavailability, Auxiliary substances. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.81

How to cite this article: Patil P, Kumbhar S, Ghorpade V. Auxiliary Substances for Enhancement of Complexation Efficiency and Dissolution Rate of Drug-Cyclodextrin Complexes. International Journal of Drug Delivery Technology. 2024;14(1):598-608.

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