International Journal of Drug Delivery Technology
Volume 14, Issue 1

Role of Drugs in the Presence of HLA-B*51 and HLA-B*51 Subtypes in Iraqi Behcet’s Disease Patients

Tharwa H H Al-Tai¹*, Hayfaa S AL-Hadithi², Dina S AL-Yasiry³

¹Department of Biology, College of Medicine, University of Baghdad, Iraq. ²Department of Microbiology, College of Medicine, University of Baghdad, Baghdad, Iraq.

³Rheumatology Unit, Department of Medicine, Baghdad Teaching Hospital Medical City, Iraq. 

Received: 10th October, 2023; Revised: 12th December, 2023; Accepted: 24th December, 2023; Available Online: 25th March, 2024

ABSTRACT

Background: Behcet’s disease (BD) is a chronic, progressive disease with an unknown cause that affects numerous organs and systems. Several alleles of HLA-B*51(HLA-B*5101, HLA-B*5108, HLA-B*5105 and HLA-B*5104) are found to be associated with Behcet’s disease.

Objective:. Detection of the most common HLA-B*51 subtypes in Iraqi Behcet’s disease patients.

Patients and methods: This study compared 60 patients with BD to 30 healthy people as a control group from December 2020 to the end of May 2021. Their blood samples were taken in order to test for the presence of HLA-B*51 and HLA-B*51 subtypes using real-time PCR (rtPCR) and the sequence-specific primers technique (PCR-SSP).

Results: HLA-B*51 frequency was highly significant among patient group 49 (81.70%) in comparison to the control group, and the most frequent subtype was HLA-B*5105 22 (36.67%) in Iraqi patients.

Conclusion: In Iraq, there may be a link between HLA-B*51 frequency and Behcet’s illness patients. HLA-B5105 was the most common subtype in Iraqi patients.

Keywords: BD, HLA-B*51, HLA-B*51 subtype.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.83

How to cite this article: Al-Tai THH, AL-Hadithi HS, AL-Yasiry DS. Role of Drugs in the Presence of HLA-B*51 and HLA-B*51 Subtypes in Iraqi Behcet’s Disease Patients. International Journal of Drug Delivery Technology. 2024;14(1):615-618.

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