International Journal of Drug Delivery Technology
Volume 14, Issue 2

Study on Natural Gums and Resins as Release Retarding Agents in Development of Sustained Release Matrix Tablets of Didanosine

Y Indira Muzib1*, K Swetha1, YR Ambedkar2

1Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati, Andhra Pradesh, India.

2College of Veterinary Science, Sri Venkateswara Veterinary Univesity, Vizianagaram, Andhra Pradesh, India. 

Received: 09th October, 2023; Revised: 08th December, 2023; Accepted: 23rd April, 2024; Available Online: 25th June, 2024

ABSTRACT

Didanosine is an anti-retroviral drug which helpful in preventing human immunodeficiency virus (HIV) from multiplication in the body. This drug has a relatively short half-life and low absolute bioavailability and requires frequent dosing. So to avoid this frequent dosing and to improve the patient’s compliance, the development of sustained-release tablets is necessary. Natural gums and resins play an important role in retarding drug release. Didanosine extended-release matrix formulations developed with wet granulation using gum kondagogu, guar gum, gum olibanum, and olibanum resin, and evaluated for pre and post-compression parameters. The outcome of all evaluation tests is reached IP specifications. Formulations with kondagogu F1-F3 failed to extend the drug release. F4-F6 was formulated with gum kondagogu and guar gum, in which F4 prolonged the release up to 12 hours with 98.23%. The formulations F7 with olibanum resin release 96.13%, and F10 with gum olibanum releases 93.15% drug at the end of 12 hours. The conclusion from the study was that natural polymers could be used to enhance drug release for an extended period.

Keywords: Didanosine, Sustained release, Natural gums, Resins, Matrix tablets.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.01

How to cite this article: Muzib YI, Swetha K, Ambedkar YR. Study on Natural Gums and Resins as Release Retarding Agents in Development of Sustained Release Matrix Tablets of Didanosine. International Journal of Drug Delivery Technology. 2024;14(2):619-624.

REFERENCES

  1. Jain KK. Drug delivery systems. 1st edition. Switzerland: Humana Press; 2008.March 7: P. 1-51.
  2. Lachman L, Herbert AL, Joseph The theory and practice of industrial pharmacy. 3rd edition. Bombay: Varghese publishing house; 1986. P. 430-455.
  3. Joseph RR, Vincent Controlled drug delivery fundamentals and applications. 2nd edition revised and expanded. New York: Marcel Dekker Inc; 1987. P. 3-56.
  4. Chien Novel drug delivery system. 2nd edition revised and expanded. New York: Informa health care; 2009. P. 1-50
  5. Gilbert SB, Christopher Modern pharmaceutics. 3rd edition revised and expanded. New York: Marcel Dekker Inc; 1995. P. 575-608.
  6. Donald LW. Handbook of pharmaceutical controlled release technology. 1st edition. New York: Marcel Dekker Inc; 2000. 431-460.
  7. Yvonne p, Thomas Pharmaceutics-Drug delivering targeting. 1st edition. Pharmaceutical press; 2010. P. 85-115, 117-139.
  8. Khalane L, Alkunte AT, Birajdar AR. Sustained release drug delivery system: a concise review. Terminology. 2016;4(5).
  9. Khan GM. Controlled release oral dosage forms: Some recent advances in matrix type drug delivery systems. The Sciences. 2001 Sep;1(5):350-4.
  10. Senapati MK, Srinatha A, Pandit JK. In Vitro Release Characteristics of Matrix Tablets: Study of Karaya Gum and Guar Gum as Release Modulators. IndianJournal of Pharmaceutical Sciences. 2006 Nov 1;68(6).DOI: 10.4103/0250-474X.31028
  11. Krishnaiah YS, Muzib YI, Rao GS, Bhaskar P, Satyanarayana Studies on the development of colon targeted oral drug delivery systems for ornidazole in the treatment of amoebiasis. Drug Delivery. 2003 Jan 1;10(2):111-7.DOI: 10.1080/713840359
  12. Chowdary KP, Mohapatra P, Krishna Evaluation of olibanum resin as microencapsulating agent for controlled drug delivery. Indian Journal of Pharmaceutical Sciences. 2006 Jul 1;68(4).
  13. Muzib YI, Kurri PS. Formulation and evaluation of gum olibanum-based sustained release matrix tablets of ambroxol International Journal of Pharmacy and Pharmaceutical Sciences. 2011
  14. Sánchez-Lafuente C, Faucci MT, Fernández-Arévalo M, Álvarez- Fuentes J, RabascoAM, Mura P. Development of sustained release matrix tablets of didanosine containing methacrylic and ethylcellulose International Journal of Pharmaceutics. 2002 Mar 2;234(1-2):213-21.DOI: 10.1016/s0378-5173(01)00962-0
  15. Soumya P, Rao NR, Revathi K, Chawda B. Design and development of oral sustained release matrix tablets of didanosine using natural polymer blend. Journal of Chemical and Pharmaceutical Research. 2013;5(12):1398-408.
  16. Dada Kodalkar, Ajit Kulkarni , Birendra Shrivastav , Harshal Tare.Preparation, Characterization of Bacterial Cellulose and Chlordiazepoxide Tablets for Oral Drug Delivery. International Journal of Pharmaceutical Quality Assurance, Volume 13 Issue 4, October - December 2022 408-412: DOI: 25258/ijpqa.13.4.11
  17. Rutu H Patel, Harsh J Trivedi, Kunal N Patel , Madhabhai M Design, Development and Optimization of Pulsatile Core in Cup Tablets of Naproxen. International Journal of Drug Delivery Technology 2017; 7(3); 220-233 doi: 10.25258/ijddt.v7i03.9565
  18. Costa P, Lobo JM. Modeling and comparison of dissolution European Journal Of Pharmaceutical Sciences. 2001 May 1;13(2):123-33. https://doi.org/10.1016/S0928-0987(01)00095-1