Exploring Antipsoriatic Potential of Aloe vera Gel

Swapnil Shinde^1*, Shrinivas Mohite²

¹Shivaji University, Kolhapur, Maharashtra, India

²Rajarambapu College of Pharmacy, Kasegaon, Sangli, Maharashtra, India. 

Received: 06^th February, 2024; Revised: 10^th March, 2024; Accepted: 17^th May, 2024; Available Online: 25^th June, 2024 

ABSTRACT

Research centers on conducting a phytochemical analysis of Aloe vera Linn leaf extracts, with an investigation into the existence of lead acetate solution, proteins, alkaloids, carbohydrates, flavonoids, cardiac glycosides, steroids, sulfur tests, and tannins. The gel formulation was tested for color, appearance, and homogeneity, and all batches produced gels that were easy to spread. Scores of 90% for the gel’s extrudability, 80% for its quality, and 70% for its fairness were given. Inhibitory effects against HaCaT cell lines were observed with the synthetic herbal component Aloe vera Linn. These effects were minor when compared to the positive control 5-FU. Several aqueous plant extracts were tested for antipsoriatic activity using the Perry scientific mouse tail method. When compared to retino A cream, the aqueous extract of Aloe vera Linn gel (500 mg/kg) improved ortho keratotic regions by 59.26%. Results suggest that Aloe vera Linn leaf extracts may have a variety of functions, including antipsoriatic and therapeutic. To completely grasp the versatility of these plant extracts, additional research is necessary.

Keywords: Aloe vera, Herbal gel, Phytochemical analysis, Stability study, Antipsoriatic activity, HaCaT Cell line. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.10

How to cite this article: Shinde S, Mohite S. Exploring Antipsoriatic Potential of Aloe vera Gel. International Journal of Drug Delivery Technology. 2024;14(2):675-680.

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