International Journal of Drug Delivery Technology
Volume 14, Issue 2

Calendula Oil Associated Dexibuprofen Nanoformulation Transdermal Patches: Formulation and Characterization

Sharan Babu RS1, Sowmya C2*, Rohith S2, Mahalakshmi K3, Monisha K4

1Department of Pharmacy Practice, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.

2Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, India.

3Department of Pharmacognosy, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.

4Department of Quality Assurance, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Chennai, India. 

Received: 21st May, 2024; Revised: 01st June, 2024; Accepted: 10th June, 2024; Available Online: 25th June, 2024 

ABSTRACT

Objectives: To prepare and characterize the nanoparticle-based topical formulations of dexibuprofen in combination with calendula oil to enhance the topical anti-inflammatory effect.

Methods: Chitosan and tri poly phosphate (TPP) were used to prepare nanoparticles developed utilizing the ionotropic gelation technique and analyzed by scanning electron microscope (SEM) and the ZS. Solvent casting was used to prepare the transdermal medication delivery system for the chitosan nanoparticle formulation.

Results: Results revealed that nanoparticles were between the sizes of 267.3 nm. This particle size may enhance the drug’s solubility and penetration through the skin. These patches containing chitosan nanoparticles were produced utilizing polymer combinations - HPMC, chitosan, and PEG400 with tween80 as plasticizers. Accompanying the rise in hydrophilic polymer content came an increase in the rate of medication release via the patch.

Conclusion: Transdermal patch - F3 released the drug reasonably well.

Keywords: Nanoparticles, Transdermal patches, Dexibuprofen, Calendula oil. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.13

How to cite this article: Babu SRS, Sowmya C, Rohith S, Mahalakshmi K, Monisha K. Calendula Oil Associated Dexibuprofen Nanoformulation Transdermal Patches: Formulation and Characterization. International Journal of Drug Delivery Technology. 2024;14(2):693-698.

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