International Journal of Drug Delivery Technology
Volume 14, Issue 2

Design and Development of Simvastatin Loaded Liposomes

Sujit Desai1,2*, Arehalli Manjappa3, Preeti Khulbe1

1School of Pharmacy, Suresh Gyan Vihar University, Mahal Rd, Mahal, Jagatpura, Jaipur, Rajasthan, India

2Padmabhushan Krantiveer Dr. Nagnath Anna Nayakawadi College of Pharmacy, Walwa, Sangli, Maharashtra, India

3Department of Pharmaceutics, Vasantidevi Patil Institute of Pharmacy, Kodoli, Kolhapur Maharashtra, India

Received: 19th January, 2024; Revised: 14th March, 2024; Accepted: 09th May, 2024; Available Online: 25th June, 2024 

ABSTRACT

Liposomes containing simvastatin were the focus of recent research. A process called thin film hydration was used to create simvastatin (SVN) liposomes. Method optimization was accomplished with the help of the BBD model. Drug content, vesicle size, surface shape, and in-vitro drug release were evaluated in the generated liposomes. There was no liposome that did not meet the criteria for appropriate drug content and mean vesicle size. Liposomes that did not combine and had a spherical or nearly spherical shape were seen in the surface morphology. The produced liposomes have demonstrated significant drug release. Liposomes loaded with SVN were successfully manufactured and tested.

Keywords: Simvastatin, In-vitro drug release, %Drug content, Liposomes

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.30

How to cite this article: Desai S, Manjappa A, Khulbe P. Design and Development of Simvastatin Loaded Liposomes. International Journal of Drug Delivery Technology. 2024;14(2):797-805.

REFERENCES

  1. Luo D, Carter KA, Molins EA, Straubinger NL, Geng J, Shao S, Jusko WJ, Straubinger RM, Lovell JF. Pharmacokinetics and pharmacodynamics of liposomal chemophototherapy with short drug-light intervals. Journal of controlled release. 2019 Mar 10;297:39-47. Available from: 1016/j.jconrel.2019.01.030
  2. Lindsey BA, Markel JE, Kleinerman Osteosarcoma overview. Rheumatology and therapy. 2017 Jun; 4:25-43. Available from: 10.1007/s40744-016-0050-2
  3. Kumbhar P, Kole K, Khadake V, Marale P, Manjappa A, Nadaf S, Jadhav R, Patil A, Singh SK, Dua K, Jha Nanoparticulate drugs and vaccines: breakthroughs and bottlenecks of repurposing in breast cancer. Journal of Controlled Release. 2022 Sep 1;349:812-830. Available from: 10.1016/j.jconrel.2022.07.039
  4. Deshantri AK, Fens MH, Ruiter RW, Metselaar JM, Storm G, Mandhane SN, Graat GH, Lentjes EG, Yuan H, de Bruijn JD, Mutis T. Complete tumor regression by liposomal bortezomib in a humanized mouse model of multiple myeloma. HemaSphere. 2020 Oct 1;4(5):e463. Available from: 10.1097/ 0000000000000463
  5. Sambamoorthy U, Manjappa AS, Eswara BR, Sanapala AK, Nagadeepthi Vitamin E oil incorporated liposomal melphalan and simvastatin: approach to obtain improved physicochemical characteristics of hydrolysable melphalan and anticancer activity in combination with simvastatin against multiple myeloma. AAPS PharmSciTech. 2022 Jan;23:1-6. Available from: 10.1208/ s12249-021-02177-6
  6. Peram MR, Jalalpure S, Kumbar V, Patil S, Joshi S, Bhat K, Diwan Factorial design-based curcumin ethosomalnanocarriers for the skin cancer delivery: in-vitro evaluation. Journal of liposome research. 2019 Jul 3;29(3):291-311. Available from: 10.1080/08982104.2018.1556292
  7. Galatage ST, Manjappa AS, Bhagwat DA, Trivedi R, Salawi A, Sabei FY, Alsalhi A. Oral self-nanoemulsifying drug delivery systems for enhancing bioavailability and anticancer potential of fosfestrol: In-vitro and in vivo European Journal of Pharmaceutics and Biopharmaceutics. 2023 Dec 1; 193:28-43. Available from: 10.1016/j.ejpb.2023.10.013
  8. Ju C, Zhang Preparation and Characterization of pH Sensitive Drug Liposomes. Liposome-Based Drug Delivery Systems. 2021:385-408. Available from: https://doi.org/10.1007/978-3- 662-49320-5_14
  9. Mast MP, Modh H, Knoll J, Fecioru E, Wacker An Update to Dialysis-Based Drug Release Testing—Data Analysis and Validation Using the Pharma Test Dispersion Releaser. Pharmaceutics. 2021 Nov 25;13(12):2007. Available from: 10.3390/pharmaceutics13122007
  10. Yadav P, Rastogi V, Verma A. Application of Box–Behnken design and desirability function in the development and optimization of self-nanoemulsifying drug delivery system for enhanced dissolution of ezetimibe. Future Journal of Pharmaceutical Sciences. 2020 Dec;6(1):1-20. Available from: https://doi.org/10.1186/s43094-020-00023-3
  11. Singh V, Haque S, Niwas R, Srivastava A, Pasupuleti M, Tripathi Strategies for fermentation medium optimization: an in-depth review. Frontiers in microbiology. 2017 Jan 6;7:2087. Available from: 10.3389/fmicb.2016.02087
  12. Unnisa A, Chettupalli AK, Alazragi RS, Alelwani W, Bannunah AM, Barnawi J, Amarachinta PR, Jandrajupalli SB, Elamine BA, Mohamed OA, Hussain T. Nanostructured Lipid Carriers to Enhance the Bioavailability and Solubility of Ranolazine: Statistical Optimization and Pharmacological Evaluations. Pharmaceuticals. 2023 Aug 14;16(8):1151. Available from: 3390/ph16081151
  13. Hirabayashi H, Takahashi T, Fujisaki J, Masunaga T, Sato S, Hiroi J, Tokunaga Y, Kimura S, Hata T. Bone-specific delivery and sustained release of diclofenac, a non-steroidal anti-inflammatory drug, via bisphosphonicprodrug based on the Osteotropic Drug Delivery System (ODDS). Journal of controlled release. 2001 Jan 29;70(1-2):183-191. Available from: https://doi.org/10.1016/ s0168-3659(00)00355-2
  14. Jing C, Li B, Tan H, Zhang C, Liang H, Na H, Chen S, Liu C, Zhao L. Alendronate-decorated nanoparticles as bone-targeted alendronate carriers for potential osteoporosis treatment. ACS Applied Bio 2021 May 19;4(6):4907-4916. Available from: 10.1021/acsabm.1c00199
  15. Olusanya TO, Haj Ahmad RR, Ibegbu DM, Smith JR, Elkordy Liposomal drug delivery systems and anticancer drugs. Molecules. 2018 Apr 14;23(4):907. Available from: 10.3390/ molecules23040907
  16. Nunes SS, Miranda SE, de Oliveira Silva J, Fernandes RS, de AlcântaraLemos J, de Aguiar Ferreira C, Townsend DM, Cassali GD, Oliveira MC, de Barros AL. pH-responsive and folate- coated liposomes encapsulating irinotecan as an alternative to improve efficacy of colorectal cancer treatment. Biomedicine & Pharmacotherapy. 2021 Dec 1; 144:112317. Available from: https://doi.org/10.1016/j.biopha.2021.112317
  17. Mane V, Killedar S, More H, Nadaf S, Salunkhe S, Tare H. Novel Phytosomal Formulation of Emblica officinalis Extracts with Its In Vivo Nootropic Potential in Rats: Optimization and Development by Box‐Behnken Design. Journal of 2024;2024(1):6644815. Available from: http://dx.doi. org/10.1155/2024/6644815
  18. Patil K, Narkhede S, Nemade M, Rane S, Chaudhari R,Dhobale G, Tare H. A Validated Sensitive Stability Indicating HPLC Method for the Determination of Etoricoxib in Bulk and Formulation. International Journal of Pharmaceutical Quality Assurance. 2023;14(2):352-357. Available from: http://dx.doi. org/10.25258/ijpqa.14.2.19
  19. Mane V, Killedar S, More H, Tare H. Preclinical study on camellia sinensis extract-loaded nanophytosomes for enhancement of memory-boosting activity: optimization by central composite design. Future Journal of Pharmaceutical Sciences. 2024 May 1;10(1):66. Available from: DOIhttps://doi.org/10.1186/s43094- 024-00639-9
  20. Chattar H, Pimple B, Kuchekar M, Tare H, Wagh V, Kachave Comparative antifungal potential of six formulated herbal shampoos against Candida albicans causing Seborrheic dermatitis. Microbial Biosystems. 2024 Jun 1;9(1):17-26. Available from: https://doi.org/10.21608/mb.2024.353426
  21. Kharate V, Kuchekar M, Harde M, Pimple B, Patole V, Salunkhe M, Wadgave P, Bhise M, Gaikwad A, Tare Development of Validated Stability Indicating HPTLC Method for Estimation of Febuxostat in Bulk and Tablet Dosage Form by Using QBD Approach. International Journal of Drug Delivery Technology. 2023;13(2):542-550. Available from: http://dx.doi.org/10.25258/ ijddt.13.2.14
  22. Mane VB, Killedar SG, More HN, Tare HL, Evaluation of acute oral toxicity of the Emblica oficinalis Phytosome Formulation in Wistar International Journal of Drug Delivery Technology. 2022;12(4):1566-1570. Available from: 10.25258/ijddt.12.4.14
  23. Ahmad S, Shaikh TJ, Patil J, Meher A, Chumbhale D, Tare H. Osmotic Release Oral Tablet Formulation, Development, and Evaluation of an Anti-epileptic International Journal of Drug Delivery Technology. 2023;13(1):305-312. Available from:10.25258/ijddt.13.1.50