International Journal of Drug Delivery Technology
Volume 14, Issue 2

Development and Evaluation of Polyherbal Phyto-phospholipid Complexes (Phytosomes) for PCOD Treatment

S Prema1, Firoj A Tamboli2, Bhupinder Bhyan3, Hanish Singh Jayasingh Chellammal4*

1Crescent School of Pharmacy B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India.

2Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.

3School of Pharmaceutical Sciences, RIMT University, Gobindgarh, Punjab, India.

4Department of Pharmacology and Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Puncak Alam, Selangor, Malaysia. 

Received: 11th January, 2024; Revised: 11th March, 2024; Accepted: 25th May, 2024; Available Online: 25th June, 2024 

ABSTRACT

olycystic ovary disorder (PCOD) is a common endocrine condition affecting women of reproductive age that is distinguished by hyperandrogenism, ovulatory failure, and polycystic ovaries. It is still not entirely apparent what causes polycystic ovary syndrome (PCOS), and the treatments that are currently available tend to focus more on alleviating symptoms than on addressing the underlying causes. The bioavailability and effectiveness of bioactive chemicals can be improved by the use of phytosomes, which are sophisticated delivery methods. Phytosomes for the treatment of polycystic ovary syndrome (PCOS) are the primary focus of this study. Materials such as milk thistle (Silybum marianum), curcumin (Curcuma longa), and Ginkgo biloba were utilized with the purpose of highlighting the potential benefits of these substances in the treatment of PCOD. A fourier-transform infrared (FTIR) analysis was carried out, and the results of the ex-vivo analysis confirmed that the formulation PS3 with a ratio of 2:1 exhibited a greater release profile.

Keywords: Polycystic ovary disorder, Phytosomes, Milk thistle, Bioavailability, Insulin resistance, Oxidative stress, Anti- inflammatory, Herbal extracts.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.37

How to cite this article: Prema S, Tamboli FA, Bhyan B, Chellammal HSJ. Development and Evaluation of Polyherbal Phyto-phospholipid Complexes (Phytosomes) for PCOD Treatment. International Journal of Drug Delivery Technology. 2024;14(2):853-857.

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