International Journal of Drug Delivery Technology
Volume 14, Issue 2

Development and Validation of Analytical Method for Estimation of Sildenafil Citrate in Swab Samples

Dushyant Gaikwad1*, Gayatri Dhobale1, Rushikesh Kakade1, Harshal Tare2

1Vishal Institute of Pharmaceutical Education and Research, Ale, Affiliated to Savitribai Phule Pune University, Pune,

Maharashtra, India.

2Dr. Harshal Tare (OPC) Pvt. Ltd., Jalgaon, Maharashtra, India. 

Received: 19th November, 2023; Revised: 17th December, 2023; Accepted: 15th April, 2024; Available Online: 25th June, 2024 

ABSTRACT

Among the most significant issues with pharmaceutical production in shared facilities is the risk of cross-contamination, which lowers product quality and costs the business a lot of money. This work set out to evaluate a cleaning approach by creating and testing a straightforward UV spectrophotometric method for estimating sildenafil citrate in swab samples. To get a good recovery from a stainless steel surface utilising a sterile cotton swab stick, the swabbing technique was fine-tuned. A wavelength of 292.20 nm was chosen for detection. Linearity, precision, accuracy, detection limit, and quantification limit were the criteria used to validate the suggested approach. A correlation coefficient of 0.9993 was determined for the regression line after studying linearity throughout a concentration range of 5 to 25 μg/mL. An average of 88.23% was recovered.

Keywords: Sildenafil citrate, Swab testing, UV- Spectroscopy, Cleaning validation.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.38

How to cite this article: Gaikwad D, Dhobale G, Kakade R, Tare H. Development and Validation of Analytical Method for Estimation of Sildenafil Citrate in Swab Samples. International Journal of Drug Delivery Technology. 2024;14(2):858-861.

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