International Journal of Drug Delivery Technology
Volume 14, Issue 2

Formulation and Evaluation of Immediate Release Tablets of Antimalarial Drug Hydroxychloroquine

Dushyant Gaikwad1, Priyanka Dhainje1, Sachin Kadam1, Harshal Tare2

1Vishal Institute of Pharmaceutical Education and Research, Ale, Affiliated to Savitribai Phule Pune University, Pune, Maharashtra, India.

2Dr. Harshal Tare (OPC) Pvt. Ltd., Jalgaon, Maharashtra, India. 

Received: 09th March, 2024; Revised: 25th May, 2024; Accepted: 05th June, 2024; Available Online: 25th June, 2024 

ABSTRACT

The goal of the study was to develop and evaluate an immediate-release antimalarial tablet formulation for the effective management of malaria, an antimalarial drug as an active pharmaceutical ingredient using excipients. Appropriate pharmaceutical products and evaluate their properties in relation to the innovative product. The study was to develop an antimalarial formulation with in-vitro solubility properties equivalent to or better than the improved formulation. Therefore, an orally administered immediate-release tablet with a robust and reproducible formulation technique was developed. According to the study, the number of F3 definitions decreased the most and F8 had the most important medicinal properties. At 20 minutes, F4 appeared to lead the first high decay rate (98. 56%), followed closely by F5 (93.48%). The expansion of F1, F2 and F3 shows high decay rates at this time. Based on this information, one can analyze and compare the decay profiles of unmistakable definitions. Things such as composition, excipients used, and manufacturing geometry can influence degradation behavior, and this information may be necessary to optimize concentrations of substances of interest for drug delivery. It is then concluded that the definition number F5 may be an optimized detail.

Keywords: Immediate release tablet, Hydroxychloroquine sulphate, Direct compression, Malerial drug. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.40

How to cite this article: Gaikwad D, Dhainje P, Kadam S, Tare H. Formulation and Evaluation of Immediate Release Tablets of Antimalarial Drug Hydroxychloroquine. International Journal of Drug Delivery Technology. 2024;14(2):872-878.

REFERENCES

  1. Gasmi A, Noor S, Menzel A, Khanyk N, Semenova Y, Lysiuk R, Beley N, Bolibrukh L, Gasmi Benahmed A, Storchylo O, Bjørklund Potential drugs in COVID-19 management. Current Medicinal Chemistry. 2024 Jul 1;31(22):3245-64.
  2. Ouabane M, Zaki K, Sekkate C, Sbai A, Bouachrine M, LakhlifiIn-silico study of 4-aminoquinoline derivatives as antimalarial agents. RHAZES: Green and Applied Chemistry. 2024 May 22;19:42-58.
  3. Nivetha GF, Vetrivelan V, Nithiyanandham T, Bayrakdar A, Muthu S, Prasath M. Quantum chemical characterization and molecular docking analysis of Hydroxychloroquine on noble Metal-Loaded silica nano Composites: Implications for COVID- 19 drug discovery. Results in Chemistry. 2024 Jan 1;7:101469.
  4. Usman S, Akram M, Usman A, Fatima S, Islam Development and assessment of immediate-release tablets containing clopidogrel bisulphate & aspirin—strategy for optimizing the combination formulation. Plos one. 2024 May 23;19(5):e0303705.
  5. Ishitsubo, N., Oguro, S., Shimahashi, H., Kawanishi, M., Adachi, T., Mitsuda, K. and Ishibashi, N., 2024. Development, physicochemical characteristics and pharmacokinetics of a new sustained-release bilayer tablet formulation of tramadol with an immediate-release component for twice-daily administration. European Journal of Drug Metabolism and Pharmacokinetics, 49(1), pp.87-100.
  6. Jadhav SB, Mali AD, Rajeghadage SH, Bathe RS. Formulation and evaluation of immediate release tablets of Imipramine hydrochloride. Int. J. Biomed. Adv. Res. 2014;5(11):559-65.
  7. Remya PN, Saraswathi TS, Sangeetha S, Damodharan N, KavithaFormulation and evaluation of immediate release tablets of acyclovir. Journal of Pharmaceutical Sciences and Research. 2016 Nov 1;8(11):1258.
  8. Reddy KM, Sahoo L, Reddy DG, Krishna Formulation and evaluation of immediate release tablets of linezolid. International Journal of Pharmaceutical & Biological Archives. 2011;2(4):1230- 5.
  9. Jagtap V, Mujawar T, Rathod A, Akhtar S, Ahmad S, Patil K, Suryavanshi J, Karande K, Gaikwad A, Mahajan K, Meher A. Formulation development and evaluation of Lovastatin fast dissolving tablets. NeuroQuantology. 2022;20(11):7234.
  10. Sonawane A, Jawale G, Devhadrao N, Bansode A, Lokhande J, Kherade D, Sathe P, Deshmukh N, Dama G, Tare Formulation And Development Of Mucoadhesive Nasal Drug Delivery Of Ropinirol HCl For Brain Targeting. International Journal of Applied Pharmaceutics. 2023;15(5):325-32.
  11. Patil K, Narkhede S, Nemade M, Rane S, Chaudhari R, Dhobale G, Tare H. A Validated Sensitive Stability Indicating HPLC Method for the Determination of Etoricoxib in Bulk and Formulation. International Journal of Pharmaceutical Quality Assurance. 2023;14(2):352-7.
  12. Ahmad S, Shaikh TJ, Patil J, Meher A, Chumbhale D, Tare H. Osmotic Release Oral Tablet Formulation, Development, and Evaluation of an Anti-epileptic Drug. International Journal of Drug Delivery Technology. 2023;13(1):305-312.
  13. Mane V, Killedar S, More H, Nadaf S, Salunkhe S, Tare H. Novel Phytosomal Formulation of Emblica officinalis Extracts with Its In Vivo Nootropic Potential in Rats: Optimization and Development by Box‐Behnken Design. Journal of Chemistry. 2024;2024(1):6644815.
  14. Ahmad S, Mujawar T, Pawara J, Sable V, Patil K, Tare H. Analytical Method Development and Validation for the Simultaneous Estimation of Olmesartan and Hydrochlorothiazide by RP-HPLC in Bulk and Tablet Dosage Forms. International Journal of Pharmaceutical Quality 2023;14(1):30-35.
  15. Mane VB, Killedar SG, More HN, Tare HL, Evaluation of acute oral toxicity of the Emblica officinalis Phytosome Formulation in Wistar International Journal of Drug Delivery Technology. 2022;12(4):1566-1570.
  16. Pund S, Dhande M, Jayatpal S, Tupe A, Deore S, Tare Scale-up and postapproval changes (SUPAC) guidelines for industry: A comprehensive review. Multidisciplinary Reviews. 2024 Jan 18;7(4):2024071-.
  17. Deshmukh P, Tare H. Socioeconomic management by effective implementation of ‘GI’ protection in rural Multidisciplinary Reviews. 2024 Feb 9;7(4):2024078.
  18. Ahmad S, Aakanksha D, Patil M, Bhise M, Barde L, Tare Development and Validation of HPLC And HPTLC for Simultaneous Analysis of E and Z Guggulsterone, A-11–KBA And 11–KBA from Herbal Formulation. International Journal of Pharmaceutical Quality Assurance. 2023;14(2):393-396.
  19. Barde L, Suruse P, Agrawal S, Kalkotwar R, Sable V, Tare H. Design, Development And Fabrication of Mouth-Dissolving Tablets Containing Extract of Tribulus terrestris For the Treatment of Hypertension. International Journal of Applied Pharmaceutics. 2023;15(3):234-41.
  20. Pund S, Chandak R, Rajurkar V, Kharat N, Khalil SS, Shaikh S, Parve K, Kadam M, Choudante S, Wakale V. A Review on Nanomedicines in Treatment of Thyroid And Their Applications in Management of Thyroid Disorders. International journal of health sciences. 2022:11141-54.
  21. Bedse A, Nalawade A, Dhamane S, Kachave R, Wagh V, Tare H, Ghangale G. Formulation and Evaluation of Herbal Remedy for Cough. International Journal of Pharmaceutical Quality Assurance. 2023;14(3):762-766.