International Journal of Drug Delivery Technology
Volume 14, Issue 2

Antifungal Niosomal Nail Lacquer for Enhanced Transungual Delivery of Efinaconazole in the Treatment of Onychomycosis

V Chatur1*, S Dhole1, N Kulkarni2

1PES Modern College of Pharmacy, Pune, Maharashtra, India.

2Department of Pharmaceutics, PES Modern College of Pharmacy, Pune, Maharashtra, India.

Received: 20th December, 2023; Revised: 16th February, 2024; Accepted: 19th May, 2024; Available Online: 25th June, 2024 

ABSTRACT

Niosomes, multilamellar vesicles, efficiently transfer active substances into the epidermis or systemic circulation. Topical medication delivery techniques increase skin permeability to active compounds. Onychomycosis, a common nail ailment caused by fungus, requires efficient topical therapies due to the risks of systemic antifungal therapy. This research aimed to make a nail polish with efinaconazole (EFN) to treat onychomycosis. The spherical Niosomes contained efinaconazole and had a 100 to 130 nm diameter. In the 24-hour in-vitro experiment, drug trapping ranged from 40 to 90% and release from 25 to 86%. The 1:2 mixtures of efinaconazole niosomes, Span 60, and CHO produced nail paint with good results. Efinaconazole-loaded niosomal nail polish had better drug release, antifungal effectiveness, and smoothness over other formulations. Topical nail polish can help low-bioavailability medicines. This method helps the medication enter the body through the nail. The ENNL can deliver onychomycosis drugs topically.

Keywords: Efinaconazole, Onychomycosis, Niosomal, Nail lacquer, Drug delivery system. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.43

How to cite this article: Chatur V, Dhole S, Kulkarni N. Antifungal Niosomal Nail Lacquer for Enhanced Transungual Delivery of Efinaconazole in the Treatment of Onychomycosis. International Journal of Drug Delivery Technology. 2024;14(2):895-901.

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