International Journal of Drug Delivery Technology
Volume 14, Issue 2

Formulation Development and Evaluation of Ticagrelor Oral Dispersible Tablets by Using Co-processed Superdisintegrants

Gayatri Dhobale1*, Soham Chavan1, Shankar Dhobale1, Harshal Tare2

1Vishal Institute of Pharmaceutical Education and Research, Ale, Affiliated to Savitribai Phule Pune University, Pune, Maharashtra, India.

2Dr. Harshal Tare (OPC) Pvt. Ltd., Jalgaon, Maharashtra, India. 

Received: 18th January, 2023; Revised: 11th March, 2024; Accepted: 13th May, 2024; Available Online: 25th June, 2024 

ABSTRACT

Ticagrelor is a contemporary anti-platelet drug that inhibits the aggregation of platelets by blocking the adenosine phosphate (ADP) receptors of the subtype P2Y12; generally utilized in patients who have a previous history of myocardial infarction or with acute coronary syndrome to prevent occurring of myocardial infarction, cardiovascular death and stroke in future. This study focuses on the development of formulation development & assessment of an oral dispersible tablet of ticagrelor, a Biopharmaceutical Classification System (BCS) class 4 drug, by using the co-processed superdisintegrants to enhance drug dissolution and bioavailability. Wet granules with different concentrations of co-processed superdisintegrants developed the tablets. This study includes seven formulations that were formulated using the different selected excipients. The various batches were assessed for physical characteristics, disintegration, dissolution studies, hardness and friability. In-vitro dissolution investigations were conducted for formulations. S1 to S7 at time points 5, 15 and 30 minutes. According to the results of the formulation S7 was discovered to be the optimum formulation, as shown 102.89% drug release at 5 minutes and a disintegration time of 16 seconds. Thus, it appears that S7 is the most suitable formulation of ticagrelor oral dispersible tablet in order for enhanced bioavailability.

Keywords: Oral dispersible tablet, Co-processed superdisintegrants, Ticagrelor, Drug delivery, Solubility enhancement,

Dissolution.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.45

How to cite this article: Dhobale G, Chavan S, Dhobale S, Tare H. Formulation Development and Evaluation of Ticagrelor Oral Dispersible Tablets by Using Co-processed Superdisintegrants. International Journal of Drug Delivery Technology. 2024;14(2):907-912.

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