International Journal of Drug Delivery Technology
Volume 14, Issue 2

Formulation and Evaluation of Brucine Sulphate Transdermal Patch for Anti-Inflammatory Activity

Gayatri Dhobale1*, Shankar Dhobale1, Rupali Hande1, Harshal Tare2

1Vishal Institute of Pharmaceutical Education and Research, Ale, Affiliated to Savitribai Phule Pune University, Pune, Maharashtra, India.

2Dr. Harshal Tare (OPC) Pvt. Ltd., Jalgaon, Maharashtra, India.

Received: 08th January, 2023; Revised: 12th March, 2024; Accepted: 14th May, 2024; Available Online: 25th June, 2024

ABSTRACT

This study was designed to develop and evaluate a transdermal patch containing brucine sulphate, a herb-based ingredient. Because of its potential to treat a wide range of illnesses with fewer side effects and higher efficacy, herbal medicines are gaining popularity in today’s society. Researchers in the field of phytoformulation have shown that there are a lot of benefits to enhancing the pharmacological activity of herbal drugs by creating nano dosage forms such as nanoparticles, nano-capsules, liposomes, nano-emulsion, and transdermal patches. Drugs can be delivered to patients in a regulated manner through transdermal drug delivery systems. It decreases systemic side effects and, in some cases, provides efficacy compared to other dose forms by enabling a consistent blood level profile. Patch preparation done by using naturally occurring polymers. Thickness, moisture content, folding endurance, and content homogeneity are some of the evaluation measures that are carried out. The transdermal patches evaluated successfully. Average weight of patch was 2.65 g, having folding endurance 94 times and pH of patch was 5.69, moisture content was 7.9%.

Keywords: Anti-inflammatory, Transdermal patches, Brucine sulphate, Formulation, Evaluation. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.51

How to cite this article: Dhobale G, Dhobale S, Hande R, Tare H. Formulation and Evaluation of Brucine Sulphate Transdermal Patch for Anti-Inflammatory Activity. International Journal of Drug Delivery Technology. 2024;14(2):945-947.

REFERENCES

  1. Song X, Wang Y, Chen H, Jin Y, Wang Z, Lu Y, Wang Y. Dosage-efficacy relationship and pharmacodynamics validation of brucine dissolving microneedles against rheumatoid Journal of Drug Delivery Science and Technology. 2021 Jun 1;63:102537.
  2. Kadian V, Rao Enhancing anti-inflammatory effect of brucine nanohydrogel using rosemary oil: a promising strategy for dermal delivery in arthritic inflammation. 3 Biotech. 2024 Jun;14(6):157.
  3. Jain B, Jain N, Jain S, Teja PK, Chauthe SK, Jain A. Exploring Brucine Alkaloid: A Comprehensive Review on Pharmacology, Therapeutic Applications, Toxicity, Extraction and Purification Techniques. Phytomedicine Plus. 2023 Sep 28:100490.
  4. Song X, Yang D, Wang Y, Liu W, Wang Y, Zhu Pharmacokinetic, acute toxicity, and pharmacodynamic studies of Semen Strychni total alkaloid microcapsules. Tropical Journal of Pharmaceutical Research. 2019;18(9):1985-92.
  5. Chakraborty S, Gupta NV, Sastri KT, Sharadha M, Chand P, Kumar H, Osmani RA, Gowda DV, Jain Current progressions in transdermal drug delivery systems for management of rheumatoid and osteoarthritis: A comprehensive review. Journal of Drug Delivery Science and Technology. 2022 Jul 1;73:103476.
  6. Ahmad S, Shaikh TJ, Patil J, Meher A, Chumbhale D, Tare H. Osmotic Release Oral Tablet Formulation, Development, and Evaluation of an Anti-epileptic Drug. International Journal of Drug Delivery Technology. 2023;13(1):305-312.
  7. Patil K, Narkhede S, Nemade M, Rane S, Chaudhari R, Dhobale G, Tare H. A Validated Sensitive Stability Indicating HPLC Method for the Determination of Etoricoxib in Bulk and Formulation. International Journal of Pharmaceutical Quality Assurance. 2023;14(2):352-357.
  8. Deshmukh P, Tare Socioeconomic management by effective implementation of ‘GI’protection in rural India. Multidisciplinary Reviews. 2024 Feb 9;7(4):2024078-.
  9. Abdul Razzaq A, Riaz T, Zaman M, Waqar MA, Ashfaq Recent advancements and various potential applications of transdermal patches. International Journal of Polymeric Materials and Polymeric Biomaterials. 2024 Jan 5:1-2.
  10. Ashfaq A, Riaz T, Waqar MA, Zaman M, Majeed I. A comprehensive review on transdermal patches as an efficient approach for the delivery of Polymer-Plastics Technology and Materials. 2024 Feb 22:1-25.
  11. Chu PC, Liao MH, Liu MG, Li CZ, Lai PS. Key Transdermal Patch Using Cannabidiol-Loaded Nanocarriers with Better Pharmacokinetics in International Journal of Nanomedicine. 2024 Dec 31:4321-37.
  12. Zhu D, Peng X, Li L, Zhang J, Xiao 3D Printed Ion-Responsive Personalized Transdermal Patch. ACS Applied Materials & Interfaces. 2024 Mar 5;16(11):14113-23.
  13. Zheng L, Chen Y, Gu X, Li Y, Zhao H, Shao W, Ma T, Wu C, Wang Q. Co-delivery of drugs by adhesive transdermal patches equipped with dissolving microneedles for the treatment of rheumatoid arthritis. Journal of Controlled Release. 2024 Jan 1;365:274-85.
  14. Song H, Liu C, Ruan J, Cai Y, Wang J, Wang X, Fang L. Rhamnose-PEG-induced supramolecular helices: Addressing challenges of drug solubility and release efficiency in transdermal Journal of Controlled Release. 2024 Mar 1;367:848-63.
  15. Fu Q, Han N, Li N, Gui L, Shi C, Rong P, Zeng F, Rao H, Chen Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch. Drug Design, Development and Therapy. 2024 Dec 31:233-55.
  16. Mane V, Killedar S, More H, Tare H. Preclinical study on camellia sinensis extract-loaded nanophytosomes for enhancement of memory-boosting activity: optimization by central composite design. Future Journal of Pharmaceutical Sciences. 2024 May 1;10(1):66.
  17. Subbukutti V, Sailatha E, Gunasekaran S, Manibalan S, Uma Devi KJ, Bhuvaneshwari K, Suvedha R. Evaluation of wound healing active principles in the transdermal patch formulated with crude bio wastes and plant extracts against GSK-3 beta-an in silico Journal of Biomolecular Structure and Dynamics. 2024 Jan 22;42(2):559-70.