International Journal of Drug Delivery Technology
Volume 14, Issue 2

Formulation, Development and In-vitro Characterization of Modified Release Tablets of Curcumin

Vikrant Nikam*, Sachin Suryawanshi, Nikita Rathod, Shruti Kadam

Department of Pharmaceutics, Amrutvahini College of Pharmacy, Sangamner, Maharashtra, India  

Received: 25th January, 2024; Revised: 20th March, 2024; Accepted: 10th May, 2024; Available Online: 25th June, 2024 

ABSTRACT

Objective: The current study set out to design and test a cost-effective system for developing modified-release tablets of curcumin in an effort to increase the duration of drug release. Because curcumin has a shorter elimination half-life, reducing the frequency of doses can increase its bioavailability.

Methods: For improved drug retardation in the stomach environment, modified-release tablets were made utilizing the wet granulation method with various grades of high-potassium chloride (HPC) as the extended-release matrix-forming agent and katira gum as the viscosity-modifying agent. Combining the use of HPC and katira gum slows the drug’s release in the stomach. The sustained-release tablets had the highest rate of medication release for up to 24 hours with almost no stomach absorption. The medication and excipients did not interact, according to the fourier-transform infrared spectroscopy (FTIR) spectra. There was no evidence of drug-excipient incompatibility, according to differential scanning calorimetry (DSC) tests. Optimal formulation batch F2 modified release tablets showed no outward signs of deterioration after three months of storage, according to stability analysis. Further evidence that F2 was steady is the lack of variation in drug content and percentage of drug release.

Conclusion: This study accomplished its stated goal of creating a modified-release tablet formulation that is both cost-effective and does not make use of coating technology.

Keywords: Curcumin, Katira gum, Modified release tablet, Hydroxy propyl cellulose, Colon. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.54

How to cite this article: Nikam V, Suryawanshi S, Rathod N, Kadam S. Formulation, Development and In-vitro Characterization of Modified Release Tablets of Curcumin. International Journal of Drug Delivery Technology. 2024;14(2):961-968.

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