International Journal of Drug Delivery Technology
Volume 14, Issue 2

Preparation and Characterization of Sustained Release Risperidone Loaded Eudragit Microparticles by Spray-Drying Technique

Arindam Chatterjee1, Amrita Pandey1*, Ashutosh Sharma1, Mayank Bansal1, Rakesh Kumar Gupta2

1Department of Pharmaceutics, Jaipur College of Pharmacy, Jaipur, Rajasthan, India.

2Department of Pharmaceutical Analysis, Jaipur College of Pharmacy, Jaipur, Rajasthan, India.

Received: 07th February, 2023; Revised: 27th April, 2024; Accepted: 21st May, 2024; Available Online: 25th June, 2024 

ABSTRACT

The goal of this work was to create novel risperidone-containing spray-dried microparticles using Eudragit® L100, a methacrylic polymer. Microparticles were designed with controlled release and enhanced in-vitro effects in mind and were meant to be taken orally. Spray-drying was used to create Eudragit® L100 microparticles loaded with risperidone. Risperidone-loaded Eudragit® L100 was successfully prepared to treat mental/mood disorders, according to an investigation into its physicochemical properties in-vitro. Spray-drying was an effective method for producing Eudragit® L100 microparticles loaded with risperidone. Formulations displayed a suitable drug entrapment percentage or nearly 89.94%. The mean diameter of the nearly spherical and spherical microparticles ranged from 30 to 50 μm, and they had a smooth surface. The distinctive peak of risperidone loaded with Eudragit L100 was visible in the fourier-transformed infrared (FTIR) spectra, indicating that the medication was fully encapsulated in the polymer. The dissolution rate of risperidone-loaded microparticles was slower than that of the pure medication. The use of spray-dried risperidone microparticles as a practical oral drug delivery method for more effective and regulated risperidone release is supported experimentally by our results.

Keywords: Schizophrenia, Autistic, Microparticle, Encapsulated, Controlled release. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.57

How to cite this article: Chatterjee A, Pandey A, Sharma A, Bansal M, Gupta RK. Preparation and Characterization of Sustained Release Risperidone Loaded Eudragit Microparticles by Spray-Drying Technique. International Journal of Drug Delivery Technology. 2024;14(2):978-983.

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