International Journal of Drug Delivery Technology
Volume 14, Issue 2

Effect of Lyophilization on Characteristics of Iloperidone Nanosuspension

Shivraj Popat Jadhav*, Prashant Kumar Dhakad, Tapasvi Gupta, Ritu Gilhotra

School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India. 

Received: 18th December, 2023; Revised: 16th March, 2024; Accepted: 14th May, 2024; Available Online: 25th June, 2024 

ABSTRACT

Objective: The primary objective of this study is to develop the nanosuspension formulation of iloperidone and to check the

effect of lyophilization on different characteristics of iloperidone nanosuspension.

Methods: Solvent-antisolvent method with probe ultrasonication was used for the formulation of nanosuspension. The nanosuspension was then converted into lyophilized form by using mannitol as a cryoprotectant and then evaluated for various parameters, including particle size, saturation solubility, scanning electron microscopy (SEM), thermal analysis, fourier- transform infrared (FTIR), in-vitro drug release study.

Result: From the study it was observed the increase in concentration of cryoprotectant while lyophilization has increased the particle size of nanosuspension. As there was an increase in particle size after lyophilization, there was a decrease in saturation solubility. In-vitro drug release also indicates a slight decrease in drug release after lyophilization. Overall, lyophilization might be used in the improvement of stability of nanosuspension, parameters must be chosen carefully for the process of lyophilization in order to obtain nanosuspension with good characteristics.

Keywords: Lyophilization, Iloperidone, Nanosuspension, Schizophrenia, Particle size. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.65

How to cite this article: Jadhav SP, Dhakad PK, Gupta T, Gilhotra R. Effect of Lyophilization on Characteristics of Iloperidone Nanosuspension. International Journal of Drug Delivery Technology. 2024;14(2):1039-1043.

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