International Journal of Drug Delivery Technology
Volume 14, Issue 2

A Comprehensive Review of Advances in Nanoparticle-Based Cancer Therapy

Abdellateif Okkod*, Sunith Reddy

Center for Pharmaceutical Science, Jawaharlal Nehru Technological University, Hyderabad, Telangana, India. 

Received: 15th January, 2024; Revised: 08th March, 2024; Accepted: 25th April, 2024; Available Online: 25th June, 2024 

ABSTRACT

A promising method for treating different kinds of cancer is cancer therapy based on nanoparticles. The goal of this thorough analysis is to present a summary of the most current developments in cancer treatment using nanoparticles and discuss the different kinds of nanoparticles and how they might be used to enhance therapeutic efficacy and deliver anticancer medications. These include mesoporous dendritic silica nanospheres, gold nanoparticles, and chitosan nanoparticles. The review stresses the significance of stability and dynamic interfaces in attaining effective drug administration and addresses the difficulties related to medication release and degradation in nanoparticle-based therapy. Moreover, it investigates the immune reactions, such as dendritic cell maturation and immune response activation, that are brought on by nanoparticle-based therapy. Overall, this thorough analysis highlights the promise of these cutting-edge strategies for enhancing the effectiveness of cancer treatment and offers insightful information about the developments in nanoparticle-based cancer therapy. The information provided in this study contributes to the growing corpus of information in the field of nanomedicine and suggests future avenues for investigation and development of treatments utilizing nanoparticles to treat cancer.

Keywords: Nanoparticles, Drug delivery, Targeted treatment, Polymeric nanoparticles, Gold nanoparticles, Nanocarriers. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.72

How to cite this article: Okkod A, Reddy S. A Comprehensive Review of Advances in Nanoparticle-Based Cancer Therapy. International Journal of Drug Delivery Technology. 2024;14(2):1077-1089.

REFERENCES

  1. Kapoor D, Sharma S, Verma K, Bisht A, Sharma M, Singhai NJ, et al. Quality-by-design-based engineered liposomal nanomedicines to t reat cancer: an in- depth Nanomedicine. 2022;17(17):1173-89.
  2. Available from: https://www.who.int/health-topics/ cancer#tab=tab_1. Accessed 2020 Jul 29.
  3. Amin H, Osman SK, Mohammed AM, Zayed Gefitinib-loaded starch nanoparticles for battling lung cancer: Optimization by full factorial design and in vitro cytotoxicity evaluation. Saudi Pharm J. 2023;31(1):29-54.
  4. Caglar HB, Baldini EH, Othus M, Rabin MS, Bueno R, Sugarbaker DJ, et al. Outcomes of patients with stage III non- small cell lung cancer treated with chemotherapy and radiation with and without surgery. Cancer. 2009;115(18):4156-66.
  5. Jonna S, Reuss JE, Kim C, Liu SV. Oral chemotherapy for treatment of lung cancer. Front Oncol. 2020;10:793.
  6. Lee MS, Dees EC, Wang Nanoparticle-Delivered Chemotherapy: Old Drugs in New Packages. Oncology (Williston Park). 2017;31(3):198-208.
  7. Tulbah AS, Pisano E, Scalia S, Young PM, Traini D, Ong HX. Inhaled simvastatin nanoparticles for inflammatory lung Nanomedicine. 2017;12(20):2471-85.
  8. Tulbah AS, Gamal A. Design and characterization of atorvastatin dry powder formulation as a potential lung cancer treatment. Saudi Pharm J. 2021;29(12):1449-57.
  9. Tulbah AS, Pisano E, Landh E, Scalia S, Young PM, Traini D, et Simvastatin nanoparticles reduce inflammation in LPS-stimulated alveolar macrophages. J Pharm Sci. 2019;108(12):3890-7.
  10. Tulbah AS. Inhaled atorvastatin nanoparticles for lung cancer. Curr Drug Deliv. 2022;19(10):1073-82.
  11. Huang W, Xing Y, Zhu L, Zhuo J, Cai Sorafenib derivatives- functionalized gold nanoparticles confer protection against tumor angiogenesis and proliferation via suppression of EGFR andVEGFR-2. Exp Cell Res. 2021;406(1):112633.
  12. Chang J, Yu B, Saltzman WM, Girardi M. Nanoparticles as a Therapeutic Delivery System for Skin Cancer Prevention and Treatment. JID Innov. 2023;100197.
  13. de la Torre P, Pérez-Lorenzo MJ, Alcázar-Garrido Á, Flores Cell-based nanoparticles delivery systems for targeted cancer therapy: Lessons from anti-angiogenesis treatments. Molecules. 2020;25(3):715.
  14. Li X, Chen L, Luan S, Zhou J, Xiao X, Yang Y, et al. The development and progress of nanomedicine for esophageal cancer diagnosis and treatment. Semin Cancer Biol. 2022 Nov;86:873-85.
  15. Blanco E, Shen H, Ferrari Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol. 2015;33(9):941-51.
  16. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021;20(2):101-24.
  17. Cheng CJ, Tietjen GT, Saucier-Sawyer JK, Saltzman A holistic approach to targeting disease with polymeric nanoparticles. Nat Rev Drug Discov. 2015;14(4):239-47.
  18. Dehelean CA, Marcovici I, Soica C, Mioc M, Coricovac D, Iurciuc S, et Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy. Molecules. 2021;26(4):1109.
  19. Suh HW, Lewis J, Fong L, Ramseier JY, Carlson K, Peng ZH, et al. Biodegradable bioadhesive nanoparticle incorporation of broad-spectrum organic sunscreen agents. Bioeng Transl Med. 2019;4(1):129-40.
  20. Xu E, Saltzman WM, Piotrowski-Daspit AS. Escaping the endosome: assessing cellular trafficking mechanisms of non-viral J Control Release. 2021;335:465-80.
  21. Prasad SB, Yashwant, Aeri V. Formulation and Evaluation of the Microsphere of Raupya Bhasma for Colon-targeted Drug Delivery. International Journal of Pharmaceutical Quality Assurance. 2022;13(3):286-289.
  22. Tadros AR, Romanyuk A, Miller IC, Santiago A, Noel RK, O’Farrell L, et STAR particles for enhanced topical drug and vaccine delivery. Nat Med. 2020;26(3):341-7.
  23. Anand U, Dey A, Chandel AKS, Sanyal R, Mishra A, Pandey DK, et Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics. Genes Dis. 2022.
  24. Peterson LL, Hurria A, Feng T, Mohile SG, Owusu C, Klepin HD, et Association between renal function and chemotherapy- related toxicity in older adults with cancer. J Geriatr Oncol. 2017;8(2):96-101.
  25. Bade BC, Cruz CS. Lung cancer 2020: epidemiology, etiology, and prevention. Clin Chest Med. 2020;41(1):1-24.
  26. Chen W, di Carlo C, Devery D, McGrath DJ, McHugh PE, Kleinsteinberg K, et al. Fabrication and characterization of gefitinib-releasing polyurethane foam as a coating for drug- eluting stent in the treatment of bronchotracheal cancer. Int J Pharm. 2018;548(2):803-11.
  27. Tulbah AS. In vitro bio-characterization of solid lipid nanoparticles of favipiravir in A549 human lung epithelial cancer J Taibah Univ Med Sci. 2023;18(5):1076.
  28. Rajivgandhi G, Stalin A, Kanisha CC, Ramachandran G, Manoharan N, Alharbi NS, et Physiochemical characterization and anti-carbapenemase activity of chitosan nanoparticles loaded egle marmelos essential oil against K. pneumoniae through DNA fragmentation assay. Surf Interfaces. 2021;23:100932.
  29. Barrera-Martínez CL, Padilla-Vaca F, Liakos I, Meléndez-Ortiz HI, Cortez-Mazatan GY, Peralta-Rodríguez RD. Chitosan microparticles as entrapment system for trans-cinnamaldehyde: Synthesis, drug loading, and in vitro cytotoxicity Int J Biol Macromol. 2021;166:322-32.
  30. Almanaa TN, Alharbi NS, Ramachandran G, Chelliah CK, Rajivgandhi G, Manoharan N, et Anti-biofilm effect of Nerium oleander essential oils against biofilm forming Pseudomonas aeruginosa on urinary tract infections. J King Saud Univ Sci. 2021;33(2):101340.
  31. Farrag NS, Shetta A, Mamdouh W. Green tea essential oil encapsulated chitosan nanoparticles-based radiopharmaceutical as a new trend for solid tumor theranosis. Int J Biol Macromol. 2021;186:811-9.
  32. Yee Kuen C, Galen T, Fakurazi S, Othman SS, Masarudin MJ. Increased cytotoxic efficacy of protocatechuic acid in A549 human lung cancer delivered via hydrophobically modified- chitosan nanoparticles as an anticancer modality. Polymers (Basel). 2020;12(9):1951.
  33. Ouyang R, Zhang Q, Cao P, Yang Y, Zhao Y, Liu B, et Efficient improvement in chemo/photothermal synergistic therapy against lung cancer using Bi@ Au nano-acanthospheres. Colloids Surf B Biointerfaces. 2023;222:113116.
  34. Song Z, Shi Y, Han Q, Dai Endothelial growth factor receptor- targeted and reactive oxygen species-responsive lung cancer therapy by docetaxel and resveratrol encapsulated lipid-polymer hybrid nanoparticles. Biomed Pharmacother. 2018;105:18-26.
  35. Parvathaneni V, Shukla SK, Kulkarni NS, Gupta Development and characterization of inhalable transferrin functionalized amodiaquine nanoparticles–Efficacy in Non-Small Cell Lung Cancer (NSCLC) treatment. Int J Pharm. 2021;608:121038.
  36. Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, et al. Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast. 2022;66:15-23.
  37. Xiong Y, Song X, Kudusi, Zu X, Chen M, He W, Qi Oncogenic GBX2 promotes the malignant behaviors of bladder cancer cells by binding to the ITGA5 promoter and activating its transcription. Funct Integr Genomics. 2022;22(5):937-50.
  38. Witjes JA, Bruins HM, Cathomas R, Compérat EM, Cowan NC, Gakis G, et al. European Association of Urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines. Eur Urol. 2021;79(1):82-104.
  39. Saginala K, Barsouk A, Aluru JS, Rawla P, Padala SA, Barsouk A. Epidemiology of bladder Med Sci (Basel). 2020;8(1):15.
  40. Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Escrig JL, et European Association of Urology guidelines on non–muscle-invasive bladder cancer (Ta, T1, and carcinoma in situ). Eur Urol. 2022;81(1):75-94.
  41. Compérat E, Amin MB, Cathomas R, Choudhury A, De Santis M, Kamat A, et al. Current best practice for bladder cancer: a narrative review of diagnostics and treatments. Lancet. 2022.
  42. Wang L, Yang D, Lv JY, Yu D, Xin SJ. Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis. Onco Targets Ther. 2017;10:1247-60.
  43. Li X, Chen L, Luan S, Zhou J, Xiao X, Yang Y, et al. The development and progress of nanomedicine for esophageal cancer diagnosis and treatment. Semin Cancer Biol. 2022 Nov;86:873-85.
  44. Zhang C, Zhao J, Wang W, Geng H, Wang Y, Gao B. Current advances in the application of nanomedicine in bladder cancer. Biomed Pharmacother. 2023;157:114062.
  45. Nguyen AV, Soulika AM. The dynamics of the skin’s immune system. Int J Mol Sci. 2019;20(8):1811.
  46. Krishnan V, Mitragotri S. Nanoparticles for topical drug delivery: Potential for skin cancer treatment. Adv Drug Deliv Rev. 2020;153:87-108.
  47. Gowda BJ, Ahmed MG, Chinnam S, Paul K, Ashrafuzzaman M, Chavali M, et al. Current trends in bio-waste mediated metal/ metal oxide nanoparticles for drug delivery. J Drug Deliv Sci Technol. 2022;71:103305.
  48. Mehan N, Kumar M, Bhatt S, Saini A current review on drug loaded nanofibers: interesting and valuable platform for skin cancer treatment. Pharm Nanotechnol. 2020;8(3):191-206.
  49. Naves LB, Dhand C, Venugopal JR, Rajamani L, Ramakrishna S, Almeida L. Nanotechnology for the treatment of melanoma skin cancer. Prog Biomater. 2017;6:13-26.
  50. Peixoto D, Pereira I, Pereira-Silva M, Veiga F, Hamblin MR, Lvov Y, et Emerging role of nanoclays in cancer research, diagnosis, and therapy. Coord Chem Rev. 2021;440:213956.
  51. Kaur H, Kesharwani P. Advanced nanomedicine approaches applied for treatment of skin carcinoma. J Control Release. 2021;337:589-611.
  52. Barenholz Doxil®—The first FDA-approved nano-drug:
  53. Lessons J Control Release. 2012;160(2):117-34.
  54. Lobo C, Lopes G, Silva O, Gluck S. Paclitaxel albumin-bound particles (abraxane™) in combination with bevacizumab with or without gemcitabine: Early experience at the University of Miami/Braman Family Breast Cancer Institute. Biomed Pharmacother. 2007;61(9):531-3.
  55. Akram D, Ahmad S, Sharmin E, Ahmad S. Silica reinforced organic–inorganic hybrid polyurethane nanocomposites from sustainable Macromol Chem Phys. 2010;211(4):412-9.
  56. De Leo V, Maurelli AM, Giotta L, Catucci L. Liposomes containing nanoparticles: preparation and Colloids Surf B Biointerfaces. 2022;112737.
  57. Kim EM, Jeong HJ. Liposomes: biomedical applications. Chonnam Med J. 2021;57(1):27.
  58. Filipczak N, Pan J, Yalamarty SSK, Torchilin VP. Recent advancements in liposome technology. Adv Drug Deliv Rev. 2020;156:4-22.
  59. Rajput R, Narkhede J, Naik Nanogels as nanocarriers for drug delivery: A review. Admet DMPK. 2020;8(1):1-15.
  60. Maddiboyina B, Desu PK, Vasam M, Challa VT, Surendra AV, Rao RS, et al. An insight of nanogels as novel drug delivery system with potential hybrid nanogel applications. J Biomater Sci Polym Ed. 2022;33(2):262-78.
  61. Korzhikov-Vlakh V, Tennikova T. Nanogels Capable of Triggered In: Tunable Hydrogels: Smart Materials for Biomedical Applications. 2021:99-146.
  62. Sivanesan I, Gopal J, Muthu M, Shin J, Mari S, Oh J. Green synthesized chitosan/chitosan nanoforms/nanocomposites for drug delivery applications. Polymers. 2021;13(14):2256.
  63. Pal K, Bharti D, Sarkar P, Anis A, Kim D, Chałas R, et al. Selected applications of chitosan composites. Int J Mol Sci. 2021;22(20):10968.
  64. Souto EB, Cano A, Martins-Gomes C, Coutinho TE, Zielińska , Silva AM. Microemulsions and nanoemulsions in skin drug delivery. Bioengineering. 2022;9(4):158.
  65. Rehman AU, Anton N, Bou S, Schild J, Messaddeq N, Vandamme TF, et al. Tunable functionalization of nano-emulsions using amphiphilic polymers. Soft Matter. 2021;17(7):1788-95.
  66. Al‐Adham IS, Jaber N, Al‐Remawi M, Al‐Akayleh F, Al‐Kaissi E, Ali Agha AS, et al. A review of the antimicrobial activity of thermodynamically stable Lett Appl Microbiol. 2022;75(3):537-47.
  67. Tawfik SM, Azizov S, Elmasry MR, Sharipov M, Lee Recent advances in nanomicelles delivery systems. Nanomaterials. 2020;11(1):70.
  68. Majumder N, Das NG, Das Polymeric micelles for anticancer drug delivery. Ther Deliv. 2020;11(10):613-635.
  69. Wan Z, Zheng R, Moharil P, Liu Y, Chen J, Sun R, et Polymeric micelles in cancer immunotherapy. Molecules. 2021;26(5):1220.
  70. D’Acunto M, Cioni P, Gabellieri E, Presciuttini G. Exploiting gold nanoparticles for diagnosis and cancer Nanotechnology. 2021;32(19):192001.
  71. Rastegari E, Hsiao YJ, Lai WY, Lai YH, Yang TC, Chen SJ, et al. An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicines. Pharmaceutics. 2021;13:1067.
  72. Mohamed Isa ED, Ahmad H, Abdul Rahman MB, Gill MR. Progress in mesoporous silica nanoparticles as drug delivery agents for cancer treatment. Pharmaceutics. 2021;13(2):152.
  73. Khan AU, Chen L, Ge G. Recent development for biomedical applications of magnetic nanoparticles. Inorg Chem Commun. 2021;134:108995.
  74. Lu C, Han L, Wang J, Wan J, Song G, Rao J. Engineering of magnetic nanoparticles as magnetic particle imaging tracers. Chem Soc Rev. 2021;50(14):8102-8146.
  75. Chavda VP, Vihol D, Mehta B, Shah D, Patel M, Vora LK, et al. Phytochemical-loaded liposomes for anticancer therapy: an updated review. Nanomedicine. 2022;17(8):547-568.
  76. Šturm L, Poklar Ulrih Basic methods for preparation of liposomes and studying their interactions with different compounds, with the emphasis on polyphenols. Int J Mol Sci. 2021;22(12):6547.
  77. Padmasree M, Vishwanath Comparison of In-vitro Release Study of PEGylated and Conventional Liposomes as Carriers for the Treatment of Colon Cancer. International Journal of Pharmaceutical Quality Assurance. 2022;13(2):204-207.
  78. Li F, Qin Y, Lee J, Liao H, Wang N, Davis TP, et al. Stimuli- responsive nano-assemblies for remotely controlled drug delivery. J Control Release. 2020;322:566-592.
  79. Daré RG, Costa A, Nakamura CV, Truiti MC, Ximenes VF, Lautenschlager SO, et al. Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection Int J Pharm. 2020;582:119336.
  80. Felippim EC, Marcato PD, Maia Campos Development of photoprotective formulations containing nanostructured lipid carriers: sun protection factor, physical-mechanical and sensorial properties. AAPS PharmSciTech. 2020;21:1-14.
  81. Iqubal MK, Iqubal A, Imtiyaz K, Rizvi MMA, Gupta MM, Ali J, et al. Combinatorial lipid-nanosystem for dermal delivery of 5-fluorouracil and resveratrol against skin cancer: Delineation of improved dermatokinetics and epidermal drug deposition enhancement Eur J Pharm Biopharm. 2021;163:223-239.
  82. Liu JQ, Zhang C, Zhang X, Yan J, Zeng C, Talebian F, et al. Intratumoral delivery of IL-12 and IL-27 mRNA using lipidnanoparticles for cancer immunotherapy. J Control Release. 2022;345:306-313.
  83. Moku G, Vangala S, Gulla SK, Yakati V. In vivo targeting of DNA vaccines to dendritic cells via the mannose receptor induces long-lasting immunity against melanoma. ChemBioChem. 2021;22(3):523-531.
  84. Palliyage GH, Hussein N, Mimlitz M, Weeder C, Alnasser MHA, Singh S, et al. Novel curcumin-resveratrol solid nanoparticles synergistically inhibit proliferation of melanoma cells. Pharm Res. 2021;38(5):851-871.
  85. Valizadeh A, Khaleghi AA, Roozitalab G, Osanloo M. High anticancer efficacy of solid lipid nanoparticles containing Zataria multiflora essential oil against breast cancer and melanoma cell lines. BMC Pharmacol Toxicol. 2021;22(1):1-7.
  86. Ilyas RA, Sapuan SM. The preparation methods and processing of natural fibre bio-polymer composites. Curr Org Synth. 2019;16(8):1068-1070.
  87. Gagliardi A, Giuliano E, Venkateswararao E, Fresta M, Bulotta S, Awasthi V, et al. Biodegradable polymeric nanoparticles for drug delivery to solid tumors. Front Pharmacol. 2021;12:601626.
  88. Wang W, Meng Q, Li Q, Liu J, Zhou M, Jin Z, et al. Chitosan derivatives and their application in biomedicine. Int J Mol Sci. 2020;21(2):487.
  89. Shanmuganathan R, Edison TNJI, LewisOscar F, Kumar P, Shanmugam S, Pugazhendhi A. Chitosan nanopolymers: an overview of drug delivery against cancer. Int J Biol Macromol. 2019;130:727-736.
  90. Narmani A, Jafari SM. Chitosan-based nanodelivery systems for cancer therapy: Recent advances. Carbohydr Polym. 2021;272:118464.
  91. Jhawat V, Gulia M, Maddiboyina B, Dutt R, Gupta S. Fate and applications of superporous hydrogel systems: a review. Curr Nanomed. 2020;10(4):326-341.
  92. Maddiboyina B, Desu PK, Vasam M, Challa VT, Surendra AV, Rao RS, et al. An insight of nanogels as novel drug delivery system with potential hybrid nanogel applications. J Biomater Sci Polym Ed. 2022;33(2):262-278.
  93. Gholap A, Tapkir A, More A, Kore P, Bagade P, Nale P, Patil A, Nagure A, Dadas A, Khamkar K. Formulation and Evaluation of Antiaging Ointment Containing Microencapsulated Turmeric and Jojoba Oil. International Journal of Drug Delivery Technology. 2023;13(4):1297-1304.
  94. Maddiboyina B, Desu PK, Vasam M, Challa VT, Surendra AV, Rao RS, et al. An insight of nanogels as novel drug delivery system with potential hybrid nanogel applications. J Biomater Sci Polym Ed. 2022;33(2):262-278.
  95. Maddiboyina B, Hanumanaik M, Nakkala RK, Jhawat V, Rawat P, Alam A, et Formulation and evaluation of gastro-retentive floating bilayer tablet for the treatment of hypertension. Heliyon. 2020;6(11).
  96. Li X, Cao C, Wei P, Xu M, Liu Z, Liu L, et al. Self-assembly of amphiphilic peptides for recognizing high furin-expressing cancer cells. ACS Appl Mater Interfaces. 2019;11(13):12327-
  97. Majumder N, Das NG, Das Polymeric micelles for anticancer drug delivery. Ther Deliv. 2020;11(10):613-635.
  98. Ghosh B, Biswas Polymeric micelles in cancer therapy: State of the art. J Control Release. 2021;332:127-147.
  99. Perumal S, Atchudan R, Lee A review of polymeric micelles and their applications. Polymers. 2022;14(12):2510.
  100. Hunter SJ, Armes SP. Pickering emulsifiers based on block copolymer nanoparticles prepared by polymerization-induced self-assembly. Langmuir. 2020;36(51):15463-15484.
  101. György C, Hunter SJ, Girou C, Derry MJ, Armes Synthesis of poly (stearyl methacrylate)-poly (2-hydroxypropyl methacrylate) diblock copolymer nanoparticles via RAFT dispersion polymerization of 2-hydroxypropyl methacrylate in mineral oil. Polym Chem. 2020;11(28):4579-4590.
  102. Du Z, Li Q, Li J, Su E, Liu X, Wan Z, et Self-assembled egg yolk peptide micellar nanoparticles as a versatile emulsifier for food-grade oil-in-water Pickering nanoemulsions. J Agric Food Chem. 2019;67(42):11728-11740.
  103. Shanmuganathan R, Edison TNJI, LewisOscar F, Kumar P, Shanmugam S, Pugazhendhi A. Chitosan nanopolymers: an overview of drug delivery against cancer. Int J Biol Macromol. 2019;130:727-736.
  104. Chen TY, Tsai MJ, Chang LC, Wu PC. Co-delivery of cisplatin and gemcitabine via viscous nanoemulsion for potential synergistic intravesical chemotherapy. Pharmaceutics. 2020;12(10):949.
  105. Prado VC, Sari MHM, Borin BC, do Carmo Pinheiro R, Cruz L, Schuch A, et al. Development of a nanotechnological-based hydrogel containing a novel benzofuroazepine compound in association with vitamin E: An in vitro biological safety and photoprotective hydrogel. Colloids Surf B Biointerfaces. 2021;199:111555.
  106. Zhan X, Teng W, Sun K, He J, Yang J, Tian J, et al. CD47- mediated DTIC-loaded chitosan oligosaccharide-grafted nGO for synergistic chemo-photothermal therapy against malignant melanoma. Mater Sci Eng C. 2021;123:112014.
  107. Hu JK, Suh HW, Qureshi M, Lewis JM, Yaqoob S, Moscato ZM, et al. Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles. Proc Natl Acad Sci. 2021;118(7)
  108. Mukherjee S, Kotcherlakota R, Haque S, Bhattacharya D, Kumar JM, Chakravarty S, et al. Improved delivery of doxorubicin using rationally designed PEGylated platinum nanoparticles for the treatment of Mater Sci Eng C. 2020;108:110375.
  109. Song M, Xia W, Tao Z, Zhu B, Zhang W, Liu C, et al. Self- assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy. Drug Deliv. 2021;28(1):594-606.
  110. Tokarska K, Lamch Ł, Piechota B, Żukowski K, Chudy M, Wilk KA, et al. Co-delivery of IR-768 and daunorubicin using mPEG-b-PLGA micelles for synergistic enhancement of combination therapy of melanoma. J Photochem Photobiol B Biol. 2020;211:111981.
  111. Xu Y, Ma S, Si X, Zhao J, Yu H, Ma L, et Polyethyleneimine‐ CpG Nanocomplex as an In Situ Vaccine for Boosting Anticancer Immunity in Melanoma. Macromol Biosci. 2021;21(2):2000207.
  112. Li S, Zhang F, Yu Y, Zhang A dermatan sulfate-functionalized biomimetic nanocarrier for melanoma targeted chemotherapy. Carbohydr Polym. 2020;235:115983.
  113. Yao Y, Zhou Y, Liu L, Xu Y, Chen Q, Wang Y, et Nanoparticle- based drug delivery in cancer therapy and its role in overcoming drug resistance. Front Mol Biosci. 2020;7:193.
  114. Al-Zahrani SA, Bhat RS, Al Rashed SA, Mahmood A, Al Fahad A, Alamro G, et Green-synthesized silver nanoparticles with aqueous extract of green algae Chaetomorpha ligustica and its anticancer potential. Green Process Synth. 2021;10(1):711-721.
  115. Włodarczyk R, Kwarciak-Kozłowska Nanoparticles from the cosmetics and medical industries in legal and environmental aspects. Sustainability. 2021;13(11):5805.
  116. Ssekatawa K, Byarugaba DK, Kato CD, Wampande EM, Ejobi F, Nakavuma JL, et al. Green strategy–based synthesis of silver nanoparticles for antibacterial applications. Front Nanotechnol. 2021;3:697303.
  117. Yesilot S, Aydin C. Silver nanoparticles; a new hope in cancer therapy? East J Med. 2019;24(1).
  118. Sayed R, Sabry D, Hedeab G, Ali HH. In vitro characterization and evaluation of silver nanoparticles cytotoxicity on human “liver and breast” cancer cells versus normal Egypt J Histol. 2019;42(3):755-766.
  119. Xu L, Wang YY, Huang J, Chen CY, Wang ZX, Xie H. Silver nanoparticles: Synthesis, medical applications and biosafety. Theranostics. 2020;10(20):8996.
  120. Daghestani M, Al Rashed SA, Bukhari W, Al-Ojayan B, Ibrahim EM, Al-Qahtani AM, et al. Bactericidal and cytotoxic properties of green synthesized nanosilver using Rosmarinus officinalis leaves. Green Process Synth. 2020;9(1):230-236.
  121. Rizwana H, Alwhibi MS, Aldarsone HA, Awad MA, Soliman DA, Bhat RS. Green synthesis, characterization, and antimicrobial activity of silver nanoparticles prepared using Trigonella foenum- graecum leaves grown in Saudi Arabia. Green Process Synth. 2021;10(1):421-429.
  122. Jadoun S, Arif R, Jangid NK, Meena Green synthesis of nanoparticles using plant extracts: A review. Environ Chem Lett. 2021;19:355-374.
  123. Naikoo GA, Mustaqeem M, Hassan IU, Awan T, Arshad F, Salim H, et al. Bioinspired and green synthesis of nanoparticles from plant extracts with antiviral and antimicrobial properties: A critical review. J Saudi Chem Soc. 2021;25(9):101304.
  124. Saravanan M, Vahidi H, Medina Cruz D, Vernet-Crua A, Mostafavi E, Stelmach R, et Emerging antineoplastic biogenic gold nanomaterials for breast cancer therapeutics: a systematic review. Int J Nanomedicine. 2020;3577-3595.
  125. Barani M, Hosseinikhah SM, Rahdar A, Farhoudi L, Arshad R, Cucchiarini M, et al. Nanotechnology in bladder cancer: diagnosis and treatment. Cancers. 2021;13(9):2214.
  126. Yafout M, Ousaid A, Khayati Y, El Otmani Gold nanoparticles as a drug delivery system for standard chemotherapeutics: A new lead for targeted pharmacological cancer treatments. Sci Afr. 2021;11
  127. Sharifi M, Attar F, Saboury AA, Akhtari K, Hooshmand N, Hasan A, et al. Plasmonic gold nanoparticles: Optical manipulation, imaging, drug delivery and therapy. J Control Release. 2019;311:170-189.
  128. Kang MS, Lee SY, Kim KS, Han DW. State of the art biocompatible gold nanoparticles for cancer theragnosis. Pharmaceutics. 2020;12(8):701.
  129. Kaur R, Singh J, Avti PK, Kumar V, Kumar R. Anisotropic Gold Nanoparticles Synthesized using Litchi chinensis Leaf Extract and their Effect on Breast International Journal of Drug Delivery Technology. 2023;13(4):1131-1138.
  130. Yang Y, Zheng X, Chen L, Gong X, Yang H, Duan X, et al. Multifunctional gold nanoparticles in cancer diagnosis and treatment. Int J Nanomedicine. 2022;2041-2067.
  131. Ahmed W, Elhissi A, Dhanak V, Subramani K. Carbon nanotubes: Applications in cancer therapy and drug delivery research. In: Emerging nanotechnologies in William Andrew Publishing; 2018. p. 371-389.
  132. Jampilek J, Kralova K. Advances in drug delivery nanosystems using graphene-based materials and carbon nanotubes. Materials. 2021;14(5):1059.
  133. Kiran AR, Kumari GK, Krishnamurthy Carbon nanotubes in drug delivery: Focus on anticancer therapies. J Drug Deliv Sci Technol. 2020;59:101892.
  134. Barabadi H, Vahidi H, Mahjoub MA, Kosar Z, Damavandi Kamali K, Ponmurugan K, et al. Emerging antineoplastic gold nanomaterials for cervical cancer therapeutics: a systematic review. J Cluster Sci. 2020;31:1173-1184.
  135. Kenchegowda M, Rahamathulla M, Hani U, Begum MY, Guruswamy S, Osmani RAM, et al. Smart nanocarriers as an emerging platform for cancer therapy: A review. Molecules. 2021;27(1):146.
  136. Castillo RR, Lozano D, Vallet-Regí M. Mesoporous silica nanoparticles as carriers for therapeutic Pharmaceutics. 2020;12(5):432.
  137. Porrang S, Davaran S, Rahemi N, Allahyari S, Mostafavi How advancing are mesoporous silica nanoparticles? A comprehensive review of the literature. Int J Nanomedicine. 2022;1803-1827.
  138. Ho YY, Sun DS, Chang Silver nanoparticles protect skin from ultraviolet b-induced damage in mice. Int J Mol Sci. 2020;21(19):7082.
  139. Miri A, Akbarpour Birjandi S, Sarani M. Survey of cytotoxic and UV protection effects of biosynthesized cerium oxide nanoparticles. J Biochem Mol Toxicol. 2020;34(6)
  140. Miri A, Beiki H, Najafidoust A, Khatami M, Sarani M. Cerium oxide nanoparticles: green synthesis using Banana peel, cytotoxic effect, UV protection and their photocatalytic Bioprocess Biosyst Eng. 2021;44(9):1891-1899.
  141. Torbati TV, Javanbakht V. Fabrication of TiO2/Zn2TiO4/Ag nanocomposite for synergic effects of UV radiation protection and antibacterial activity in sunscreen. Colloids Surf B Biointerfaces. 2020;187:110652.
  142. Rizzi V, Gubitosa J, Fini P, Nuzzo S, Agostiano A, Cosma
  143. Snail slime-based gold nanoparticles: An interesting potential ingredient in cosmetics as an antioxidant, sunscreen, and tyrosinase inhibitor. J Photochem Photobiol B Biol. 2021;224:112309.
  144. Amatya R, Hwang S, Park T, Chung YJ, Ryu S, Lee J, et BSA/ silver nanoparticle-loaded hydrogel film for local photothermal treatment of skin cancer. Pharm Res. 2021;38:873-883.
  145. Ji W, Li L, Zhou S, Qiu L, Qian Z, Zhang H, et Combination immunotherapy of oncolytic virus nanovesicles and PD-1 blockade effectively enhances therapeutic effects and boosts antitumour immune response. J Drug Target. 2020;28(9):982-990.
  146. Mo C, Lu L, Liu D, Wei K. Development of erianin-loaded dendritic mesoporous silica nanospheres with pro-apoptotic effects and enhanced topical delivery. J Nanobiotechnology. 2020;18(1):1-14.
  147. Li TF, Xu HZ, Xu YH, Yu TT, Tang JM, Li K, et al. Efficient delivery of chlorin e6 by polyglycerol-coated iron oxide nanoparticles with conjugated doxorubicin for enhanced photodynamic therapy of melanoma. Mol Pharm. 2021;18(9):3601-3615.
  148. Huang W, Xing Y, Zhu L, Zhuo J, Cai Sorafenib derivatives- functionalized gold nanoparticles confer protection against tumor angiogenesis and proliferation via suppression of EGFR and VEGFR-2. Exp Cell Res. 2021;406(1):112633