International Journal of Drug Delivery Technology
Volume 14, Issue 2

Drug-Coated Central Venous Catheters - A Comprehensive Review of Strategies in the Development to Overcome Biofilm Formation and Related Infections

Nissara Ahammed1*, Revathi Sundaramoorthi2, Venkatesh Dinnekere Puttegowda3

1Department of Pharmaceutics, School of Pharmacy, Sri Balaji Vidyapeeth Deemed to be University, Pillaiyarkuppam, Puducherry, India.

2Department of Pharmaceutics, School of Pharmacy, Sri Balaji Vidyapeeth Deemed to be University, Pillaiyarkuppam, Puducherry, India.

3Department of Pharmaceutics, Acharya B.M. Reddy college of Pharmacy, Bengaluru, India 

Received: 21st May, 2024; Revised: 01st June, 2024; Accepted: 10th June, 2024; Available Online: 25th June, 2024 

ABSTRACT

Central venous catheters (CVCs) are implantable medical instruments regularly used in intense care units for the easy introduction of medical drugs and medicaments, to give fluids intravenously, nutriments, transfusion of blood and also to withdraw blood samples. Bloodstream infections associated with the usage of catheters are the most recurrent, harmful as well as expensive impediment. This is the omnipresent reason for the introduction of bacteria and related infections. Among the various types of medical devices, the rate of infection, morbidity and mortality are higher with the usage of CVCs than any other types of medical instruments. Biofilm developed due to contamination by microorganisms. The biofilm is a bunch of microorganisms accumulated on the surface of CVCs. These biofilms contribute to the proliferation of microbes and increase antimicrobial resistance against antibiotics, affect the host’s immunity and get spread to the various body parts. Numerous approaches have been evolved to overcome the above mentioned issues associated with the usage of CVCs. In the said review, the authors have summarized the usage of CVCs, biofilm formation, development of infection, strategies and innovations in the modification of CVCs aiming to avoid the CRBSI and subsequent resistance to antimicrobial drugs.

Keywords: Drug-coated central venous catheters, Biofilm, Catheter-related bloodstream infections, Resistance, Coated

catheters.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.86

How to cite this article: Ahammed N, Sundaramoorthi R, Puttegowda VD. Drug-Coated Central Venous Catheters - A Comprehensive Review of Strategies in the Development to Overcome Biofilm Formation and Related Infections. International Journal of Drug Delivery Technology. 2024;14(2):1198-1208.

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