International Journal of Drug Delivery Technology
Volume 14, Issue 2

Formulation, Characterization and Stability Aspects of Mesoporous Silica Nanoparticles

Neha Padiyar1, Nidhi Nainwal1*, Yogita Ale1, Deepika Galwan1,2

1Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Premnagar, Dehradun, Uttarakhand, India.

2Shri Dev Bhoomi Institute of Education Science Education and Technology, Dehradun, India.

Received: 29th March, 2024; Revised: 10th April, 2024; Accepted: 30th May, 2024; Available Online: 25th June, 2024 

ABSTRACT

Mesoporous silica nanoparticles are a type of inorganic nanoparticles having mesopores of 2 to 50 nm in size. The nanosized mesoporous particles of silica facilitate endocytosis in drug targeting without any side effects. Mesoporous silica nanoparticle (MSN) can be used to deliver a variety of therapeutic agents or gene delivery through active or chemical adsorption. MSNs can be used in the field of biomedical for the detection and treatment of various diseases like cancers, infection, inflammation, diabetes, bone-related disorders, cardiac diseases, neurodegenerative diseases, etc. The unique characteristics of MSNs in the form of easily adjustable pore size, surface area, particle size, pore volume, and surface morphology are advantageous not only in the biomedical field but also in the fields of biosensors, imaging, agriculture, thermal energy, and catalysis, etc. MSNs provide high surface area, easy surface functionalization, and controlled drug release. MSNs are formulated after condensation of silica in the presence of molecular templates like surfactants and polymers. This review article focused on giving in-depth knowledge about formulation techniques. Various types of excipients, such as catalysts, silica, solvents and surfactants utilized for the formulation of silica-based nanoparticles, have been summarized. The characterization of MSNs using suitable techniques was also reviewed. The stability of MSNs and factors affecting their stability is a crucial part of formulation development that is discussed here.

Keywords: Mesoporous silica nanoparticles, Formulation, Excipients, Evaluation, Stability. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.88

How to cite this article: Padiyar N, Nainwal N, Ale Y, Galwan D. Formulation, Characterization and Stability Aspects of Mesoporous Silica Nanoparticles. International Journal of Drug Delivery Technology. 2024;14(2):1217-1224.

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