International Journal of Drug Delivery Technology
Volume 14, Issue 2

Incorporating Kappa-carrageenan in Liposomes Facilitates Development of Lipopolysaccharide Hybrid Nanoplatform

Suvaasni Prasad$, Kiruthigaa Krishnan$, Sivaramakrishnan Venkatabalasubramanian$*

Department of Genetic Engineering, College of Engineering and Technology, SRM Institute of Science and Technology, Chennai, Tamil Nadu, India.

Received: 25th March, 2023; Revised: 10th April, 2024; Accepted: 10th May, 2024; Available Online: 25th June, 2024 

ABSTRACT

Sulfated polysaccharides (kappa-carrageenan) integration in lipids provides diverse structural and physicochemical properties in nanotechnology. Such a lipopolysaccharide hybrid (LPHS) system offers superior applications in the food and pharmaceutical industry. This study investigates the synthesis and characterization of sulfated polysaccharide (kappa-carrageenan: κ-CG) integrated smart liposomes (cubosomes) for establishing cubic tendency in the LPHS system. The κ-CG integrated smart liposomes were prepared using the modified thin film hydration approach. Characterization studies (liposomes and smart liposomes) were performed using dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). DLS studies confirmed the nano-range of both delivery systems. The SEM and TEM investigation revealed the formation of classical cubic morphology of the smart liposomes. Sulfated polysaccharide (κ-CG) integrated smart liposomes exhibited an enhanced κ-CG release profile compared to the liposome-free κ-CG alone. This was due to improved entrapment efficiency (68%) and better overall stability established by the κ-CG incorporation.

Keywords: Kappa-carrageenan, Nanoplatform, Drug-delivery system, Smart liposome, Self-assembly. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.09

How to cite this article: Prasad S, Krishnan K, Venkatabalasubramanian S. Incorporating Kappa-carrageenan in Liposomes Facilitates Development of Lipopolysaccharide Hybrid Nanoplatform. International Journal of Drug Delivery Technology. 2024;14(2):670-674.

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