International Journal of Drug Delivery Technology
Volume 14, Issue 2

Solid lipid Nanoparticles and Nanostructured Lipid Carrier: A Novel Approach for Lipid-Based Drug Delivery System

Naimish Nanda1*,Chozharajan Tharmaraj2, Saswati Panigrahi3, Mandadi Sandhya Rani4

1Faculty of Pharmacy, Kalinga University, Naya Raipur, Chhattisgarh, India

2Department of Pharmaceutics, Immanuel Arasar College of Pharmacy, Nattalam, Marthandam

3St. John Institute of Pharmacy and Research, Palghar, Maharashtra, India

4Department of Pharmaceutics, Vishnu Institute of Pharmaceutical Education and Research, Telangana, India 

Received: 15th January, 2024; Revised: 08th March, 2024; Accepted: 25th April, 2024; Available Online: 25th June, 2024 

ABSTRACT

Lipid nanoparticles, or LNPs, including nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs), attracted a lot of attention lately. SLNs were formed to circumvent the confines of the most common colloidal carriers because of their benefits, which include a favorable profile of release and precise administration of the drug with great physical stability. NLCs are the succeeding group of lipid nanoparticles with better capacity loading and durability. There are three possible NLC structural models. These LNPs may find usage in clinical medicine, research, cosmetics, and drug delivery.

Keywords: Drug delivery systems, Nanoparticles, Nanostructured lipid carriers, Solid lipid nanoparticles. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.2.90

How to cite this article: Nanda N, Tharmaraj C, Panigrahi S, Rani MS. Solid lipid Nanoparticles and Nanostructured Lipid Carrier: A Novel Approach for Lipid-Based Drug Delivery System. International Journal of Drug Delivery Technology. 2024;14(2):1232-1238.

REFERENCES

  1. Mishra, V.; Bansal, K.K.; Verma, A.; Yadav, N.; Thakur, S.; Sudhakar, K.; Rosenholm, J.M. Solid lipid nanoparticles: Emerging colloidal nano drug delivery systems. Pharmaceutics 2018, 10, 191.
  2. Haider M, Abdin SM, Kamal L, Orive Nanostructured lipid carriers for delivery of chemotherapeutics: A review. Pharmaceutics. 2020;12(3):288.
  3. Chauhan I, Yasir M, Verma M, Singh Nanostructured Lipid Carriers: A Groundbreaking Approach for Transdermal Drug Delivery. Adv Pharm Bull. 2020 Jun;10(2):150–65.
  4. Smith, T.; Affram, K.; Nottingham, E.L.; Han, B.; Amissah, F.; Krishnan, S.; Trevino, J.; Agyare, E. Application of smart solid lipid nanoparticles to enhance the efficacy of 5-fluorouracil in the treatment of colorectal cancer. Sci. Rep. 2020, 10, 16989.
  5. Khosa, A.; Reddi, S.; Saha, R.N. Nanostructured lipid carriers for site-specific drug delivery. Biomed. Pharmacother. 2018, 103, 598–613.
  6. Subramaniam, B.; Siddik, Z.H.; Nagoor, N.H. Optimization of nanostructured lipid carriers: Understanding the types, designs, and parameters in the process of J. Nanopart. Res. 2020, 22, 141.
  7. Talarico, ; Consumi, M.; Leone, G.; Tamasi, G.; Magnani, A. Solid lipid nanoparticles produced via a coacervation method as promising carriers for controlled release of Quercetin. Molecules 2021, 26, 2694.
  8. Tan, C.P.; Schwarz, K. Development and characterization of solid lipid nanoparticles (SLNs) made of cocoa butter: A factorial design study. Food Eng. 2018, 231, 30–41
  9. He, J.; Huang, S.; Sun, X.; Han, L.; Chang, C.; Zhang, W.; Zhong, Q. Carvacrol Loaded Solid Lipid Nanoparticles of Propylene Glycol Monopalmitate and Glyceryl Monostearate: Preparation, Characterization, and Synergistic Antimicrobial Activity. Nanomaterials 2019, 9, 1162.
  10. Li, ; Wu, Z.-F.; Kuang, W.-W.; Li, Y.-H.; Chen, B.-Y.; Yang, M. Effect of nanostructured lipid carriers (NLCs) in improving the stability of essential oils and its application. China J. Chin. Mater. Med. 2020, 45, 523–530.
  11. Ban, ; Jo, M.; Park, Y.H.; Kim, J.H.; Han, J.Y.; Lee, K.W.; Kweon, D.-H.; Choi, Y.J. Enhancing the oral bioavailability of curcumin using solid lipid nanoparticles. Food Chem. 2020, 302, 125328
  12. Borges, ; De Freitas, V.; Mateus, N.; Fernandes, I.; Oliveira, J. Solid lipid nanoparticles as carriers of natural phenolic compounds. Antioxidants 2020, 9, 998.
  13. Zhong, ; Zhang, L. Nanoparticles fabricated from bulk solid lipids: Preparation, properties, and potential food applications. Adv. Colloid Interface Sci. 2019, 273, 102033.
  14. Kumar, R.; Singh, A.; Garg, N. Acoustic cavitation assisted hot melt mixing technique for solid lipid nanoparticles formulation, characterization, and controlled delivery of poorly water soluble drugs. Drug Deliv. Sci. Technol. 2019, 54, 101277.
  15. Esfanjani, A.F.; Assadpour, E.; Jafari, S.M. Improving the bioavailability of phenolic compounds by loading them within lipid-based nanocarriers. Trends Food Sci. Technol. 2018, 76,56–66.
  16. Salvi, V.R.; Pawar, P. Nanostructured lipid carriers (NLC) system: A novel drug targeting carrier. Drug Deliv. Sci. Technol. 2019, 51, 255–267.
  17. Gratieri, ; Krawczyk-Santos, A.P.; Da Rocha, P.B.R.; Cunha- Filho, M.; Gelfuso, G.M.; Marreto, R.N.; Taveira, S.F. SLN- and NLC-Encapsulating Antifungal Agents: Skin Drug Delivery and their Unexplored Potential for Treating Onychomycosis. Curr. Pharm. Des. 2017, 23, 6684–6695.
  18. Tan, S.L.; Billa, N. Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles. Pharmaceutics 2021, 13, 1817.
  19. Algarni, A.; Pilkington, E.H.; Suys, E.J.A.; Al-Wassiti, H.; Pouton, W.; Truong, N.P. In-vivo delivery of plasmid DNA by lipid nanoparticles: The influence of ionizable cationic lipids on organ-selective gene expression. Biomater. Sci. 2022, 10, 2940–2952.
  20. Melamed, J.R.; Yerneni, S.S.; Arral, M.L.; LoPresti, S.T.; Chaudhary, N.; Sehrawat, A.; Muramatsu, H.; Alameh, M.-G.; Pardi, N.; Weissman, D.; et al. Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer. Adv. 2023, 9, eade1444
  21. Narmani, ; Rezvani, M.; Farhood, B.; Darkhor, P.; Mohammadnejad, J.; Amini, B.; Refahi, S.; Abdi Goushbolagh, N. Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems. Drug Dev. Res. 2019, 80, 404–424
  22. Viegas, S.R.; Praça, F.G.; Caron, A.L.; Suzuki, I.; Silvestrini, A.V.P.; Medina, W.S.G.; Del Ciampo, J.O.; Kravicz, M.; Bentley,
  23. V.L.B. Nanostructured lipid carrier co-delivering tacrolimus and TNF-α siRNA as an innovate approach to psoriasis. Drug Deliv. Transl. Res. 2020, 10, 646–660
  24. Hassett, K.J.; Benenato, K.E.; Jacquinet, E.; Lee, A.; Woods, A.; Yuzhakov, O.; Himansu, S.; Deterling, J.; Geilich, B.M.; Ketova, T.; et al. Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines. Ther. Nucleic Acids 2019, 15, 1–11.
  25. Souto, E.B.; Baldim, I.; Oliveira, W.P.; Rao, R.; Yadav, N.; Gama, M.; Mahant, S. SLN, and NLC for topical, dermal, and transdermal drug delivery. Expert Opin. Drug Deliv. 2020, 17, 357–377.
  26. Sgorla, D.; Lechanteur, A.; Almeida, A.; Sousa, F.; Melo, E.; Bunhak, É.; Mainardes, ; Khalil, N.; Cavalcanti, O.; Sarmento, B. Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery. Expert Opin. Drug Deliv. 2018, 15, 213–222
  27. Dudhipala, N.; Janga, K.Y.; Gorre, T. Comparative study of nisoldipine-loaded nanostructured lipid carriers and solid lipid nanoparticles for oral delivery: Preparation, characterization, permeation, and pharmacokinetic evaluation. Cells Nanomed. Biotechnol. 2018, 46, 616–625.
  28. Castellani, S.; Trapani, A.; Spagnoletta, A.; Di Toma, L.; Magrone, ; Di Gioia, S.; Mandracchia, D.; Trapani, G.; Jirillo, E.; Conese, M. Nanoparticle delivery of grape seed-derived proanthocyanidins to airway epithelial cells dampens oxidative stress and inflammation. J. Transl. Med. 2018, 16, 140.
  29. Malta, ; Loureiro, J.B.; Costa, P.; Sousa, E.; Pinto, M.; Saraiva, L.; Amaral, M.H. Development of lipid nanoparticles containing the xanthone LEM2 for topical treatment of melanoma. J. Drug Deliv. Sci. Technol. 2021, 61, 102226
  30. Neves, R.; van der Putten, L.; Queiroz, J.F.; Pinheiro, M.; Reis,S. Transferrin-functionalized lipid nanoparticles for curcumin brain delivery. J. Biotechnol. 2021, 331, 108–117
  31. Magalhães, ; Chaves, L.L.; Vieira, A.C.; Santos, S.G.; Pinheiro, M.; Reis, S. Optimization of rifapentine-loaded lipid nanoparticles using a quality-by-design strategy. Pharmaceutics 2020, 12, 75.
  32. Cacicedo, M.L.; Ruiz, M.C.; Scioli-Montoto, S.; Ruiz, M.E.; Fernández, M.A.; Torres-Sanchez, R.M.; Baran, E.J.; Castro, R.; León, I.E. Lipid nanoparticles—Metvan: Revealing a novel way to deliver a vanadium compound to bone cancer cells. New
  33. Chem. 2019, 43, 17726–17734.
  34. Dai, Y.; Huang, J.; Xiang, B.; Zhu, H.; He, C. Antiproliferative and apoptosis triggering potential of paclitaxel-based targeted- lipid nanoparticles with enhanced cellular internalization by transferrin receptors—A study in leukemia cells. Nanoscale Res. Lett. 2018, 13, 271.
  35. Gonçalves, F.S.; Martins, J.T.; Abrunhosa, L.; Baixinho, J.; Matias, A.A.; Vicente, A.A.; Pinheiro, A.C. Lipid-based nanostructures as a strategy to enhance curcumin bioaccessibility: Behavior under digestion and cytotoxicity assessment. Food Res. Int. 2021, 143, 110278.
  36. Hashemi, F.S.; Farzadnia, F.; Aghajani, A.; Ahmadzadeh NobariAzar, F.; Pezeshki, A. Conjugated linoleic acid loaded nanostructured lipid carrier as a potential antioxidant nanocarrier for food applications. Food Sci. Nutr. 2020, 8, 4185–4195.
  37. Agrawal, M.; Saraf, S.; Saraf, S.; Dubey, S.K.; Puri, A.; Patel, R.J.; Ajazuddin; Ravichandiran, ; Murty, U.S.; Alexander, A. Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting. J. Control Release 2020, 321, 372–415.
  38. Akbari, J.; Saeedi, M.; Ahmadi, F.; Hashemi, S.M.H.; Babaei, A.; Yaddollahi, S.; Rostamkalaei, S.S.; Asare-Addo, K.; Nokhodchi, Solid lipid nanoparticles and nanostructured lipid carriers: A review of the methods of manufacture and routes of administration. Pharm. Dev. Technol. 2022, 27, 525–544.
  39. Marques, A.C.; Costa, P.C.; Velho, S.; Amaral, M.H. Lipid Nanoparticles Functionalized with Antibodies for Anticancer Drug Therapy. Pharmaceutics 2023, 15, 216.
  40. Di Filippo, L.D.; Lobato Duarte, J.; Hofstätter Azambuja, J.;Glioblastoma multiforme targeted delivery of docetaxel using bevacizumab-modified nanostructured lipid carriers impair in-vitro cell growth and in-vivo tumor progression.
  41. Pharm. 2022, 618, 121682.
  42. Soares, S.; Sousa, J.; Pais, A.; Vitorino, C. Nanomedicine: Principles, Properties, and Regulatory Front. Chem. 2018, 6, 360.
  43. Patra, J.K.; Das, G.; Fraceto, L.F.; Campos, E.V.R.; del Pilar Rodriguez-Torres, M.; Acosta-Torres, L.S.; Diaz-Torres, L.A.; Grillo, R.; Swamy, M.K.; Sharma, S.; et al. Nano-based drug delivery systems: Recent developments and future prospects. Nanobiotechnol. 2018, 16, 71.
  44. Uner, B.; Ozdemir, S.; Yildirim, E.; Yaba, A.; Tas, C.; Uner, M.; Ozsoy, Loteprednol loaded nanoformulations for corneal delivery: Ex-vivo permeation study, ocular safety assessment and stability studies. J. Drug Deliv. Sci. Technol. 2023, 81, 104252.
  45. Lopes, C.; Cristóvão, J.; Silvério, V.; Lino, P.R.; Fonte, P. Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications. Expert Opin. Drug Deliv. 2022, 19, 1381–1395.
  46. Akel, ; Ismail, R.; Katona, G.; Sabir, F.; Ambrus, R.; Csóka, I. A comparison study of lipid and polymeric nanoparticles in thenasal delivery of meloxicam: Formulation, characterization, and
  47. in-vitro Int. J. Pharm. 2021, 604, 120724.
  48. Ghasemiyeh, P.; Mohammadi-Samani, S.J.R.i.p.s. Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: Applications, advantages, and disadvantages. Pharm. Sci. 2018, 13, 288.
  49. Dhiman, ; Awasthi, R.; Sharma, B.; Kharkwal, H.; Kulkarni,
  50. T. Lipid Nanoparticles as Carriers for Bioactive Delivery. Front. Chem. 2021, 9, 580118
  51. Huang, ; Li, J.; Kebebe, D.; Wu, Y.; Zhang, B.; Liu, Z. Cell-penetrating peptides functionalized gambogic acid- nanostructured lipid carrier for cancer treatment. Drug Deliv. 2018, 25, 757–765.
  52. Kebebe, D.; Wu, Y.; Zhang, B.; Yang, J.; Liu, Y.; Li, X.; Ma, Z.; Lu, P.; Liu, Z.; Li, J. Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer. J. Nanomed. 2019, 14, 6179–6195.
  53. Cheng, Q.; Wei, T.; Farbiak, L.; Johnson, L.T.; Dilliard, S.A.; Siegwart, D.J. Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing. Nanotechnol. 2020, 15, 313–320.
  54. Wang, X.; Liu, S.; Sun, Y.; Yu, X.; Lee, S.M.; Cheng, Q.; Wei, T.; Gong, J.; Robinson, J.; Zhang, D.; et al. Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery. Protoc. 2023, 18, 265–291.
  55. Yan, ; Kang, D.D.; Dong, Y. Harnessing lipid nanoparticles for
  56. efficient CRISPR Biomater. Sci. 2021, 9, 6001–6011.
  57. Marante, ; Viegas, C.; Duarte, I.; Macedo, A.S.; Fonte, P. An Overview on Spray-Drying of Protein-Loaded Polymeric Nanoparticles for Dry Powder Inhalation. Pharmaceutics 2020, 12, 1032.
  58. Kaur, ; Mishra, V.; Shunmugaperumal, T.; Goyal, A.K.; Ghosh, G.; Rath, G. Inhalable spray dried lipid nanoparticles for the co-delivery of paclitaxel and doxorubicin in lung cancer. J. Drug Deliv. Sci. Technol. 2020, 56, 101502.
  59. Ganesh Pawbake, Satish V. Shirolkar. Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein. Sys Rev Pharm 2020; 11(6): 794 802.
  60. Sartaj A, Annu, Biswas L, Verma AK, Sahoo PK, Baboota S, Ali Ribociclib Nanostructured Lipid Carrier Aimed for Breast Cancer: Formulation Optimization, Attenuating In-vitro Specification, and In-vivo Scrutinization. Biomed Res Int. 2022 3;2022:6009309.
  61. Bodige Pavan Kalyan, Sreepada Navysri, Jangili Hemalatha. Formulation and Evaluation of Nanostructured Lipid Carrier Delivery of Celecoxib. International Journal of Research Publication and Reviews.2021.2(4) :595-600
  62. Anupam Kr. Sachan, Saurabh Singh and Anupriya Kapoor. Formulation and evaluation of nanostructured lipid carrier for the management of psoriasis. IJPSR, 2021;12(6): 3381-3390.
  63. Ankam Saraswathi, Sunit Kumar Sahoo. Nisoldipine Loaded Solid Lipid Nanoparticles and Nanostructured Lipid Carriers. Indian Journal of Pharmaceutical Education and Research .2020.2(54).
  64. Brito Raj, , Chandrasekhar, K.B. & Reddy, K.B. Formulation, in-vitro and in-vivo pharmacokinetic evaluation of simvastatin nanostructured lipid carrier loaded transdermal drug delivery system. Futur J Pharm Sci 2019,5, 9.