International Journal of Drug Delivery Technology
Volume 14, Issue 3

Cytoprotective Effects of Phloretin on Long-Term Post-Prandial Hyperglycemia-induced Esophageal Damage in Rats

Neelkanth M Pujari1,2, Mohammad Khushtar1, Anuradha Mishra1,3*, Deepika Gupta4

1Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

2Faculty of Pharmacy, Dr. APJ Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India.

3Amity Institute of Pharmacy, Lucknow, Amity University, Uttar Pradesh, Noida, India.

4Maharishi School of Pharmaceutical Sciences, Maharishi University of Information Technology, Lucknow, Uttar Pradesh, India. 

Received: 19th March, 2024; Revised: 18th June, 2024; Accepted: 10th August, 2024; Available Online: 25th September, 2024 

ABSTRACT

Esophageal damage arises from gastroesophageal reflux disease, where the contents of the stomach and duodenum flow back into the esophagus, causing an inflammatory lesion. Phloretin, a phytoconstituent classified as a flavonoid possessing both nutritional and medicinal properties, was the focus of this study. The experiment aimed to investigate the impact of phloretin on experimental esophagitis in albino rats. Rats in various groups underwent the induction of esophagitis through the administration of a Fructose solution (10%) and indomethacin (5mg/Kg). The resulting hyperglycemia from regular Fructose solution intake over 28 days was assessed. After sacrifice, the rats were evaluated for the esophagitis index. Additionally, esophageal tissues underwent further analysis for oxidative stress parameters, including TBARS, SOD, Catalase and GSH. Treatment with phloretin demonstrated a significant inhibition of the esophagitis index. Furthermore, phloretin contributed to the restoration of altered levels of oxidative stress parameters back to normal.

Keywords: Acid reflux, Post-prandial hyperglycemia, Esophagitis, Oxidative stress, Flavonoid. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.10

How to cite this article: Pujari NM, Khushtar M, Mishra A, Gupta D. Cytoprotective Effects of Phloretin on Long-Term Post-Prandial Hyperglycemia-induced Esophageal Damage in Rats. International Journal of Drug Delivery Technology. 2024;14(3):1323-1327.

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