International Journal of Drug Delivery Technology
Volume 14, Issue 3

Comparison Study of Aloin-Curcumin Nanoparticles by Taking 2 Different Ratios and Analyses by Using Drug Design Experimental Study

Rishika Chauhan1, Balwan Singh2, Ram Dayal3, Anuj Malik4*

1Department of Pharmaceutics, M M College of Pharmacy, Maharshi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India.

2School of Pharmacy, KIET Group of Institutions, Delhi-NCR, Ghaziabad, Uttar Pradesh, India.

3Collge of Pharmacy, Accurate Group of Institutions, Greater Noida, Uttar Pradesh, India.

4Department of Pharmaceutics, M M College of Pharmacy, Maharshi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India. 

Received: 16th March, 2024; Revised: 23rd May, 2024; Accepted: 02nd August, 2024; Available Online: 25th September, 2024

ABSTRACT

Numerous chemopreventive drugs like aloin and curcumin have demonstrated potential effects in cancer treatment; however, their efficacy is limited by low bioavailability. Thus, the primary goal of this research was to formulate a unique method by using the herbal drugs synergistically and improve the bioavailability of these anticancer drugs here, using the nanoprecipitation method for two well-active constituents of known natural herbal compounds. Aloin (AL)-curcumin (CUR) were co-loaded into polymeric nanoparticles made of poly (D, L-lactide-co-glycolide) and surfactant-polyvinyl alcohol, with the experiment’s response being evaluated using Stat-Ease software. To create dual-loaded nanoparticles containing aloin and curcumin, using different ratios sand optimizing the best formulation. (60:120). For aloin curcumin, optimize the better formulation with controlled release formulation having less than 100 nm size of particle and drug entrapment was 86.09% while for (60:60) of aloin -curcumin having 99.1 nm particle size of drug and encapsulation efficiency was 72.05%.

Keywords: Nanoparticulate, Design expert, Phytochemicals, Controlled release, Aloin- curcumin combination, Radiometric delivery.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.18

How to cite this article: Chauhan R, Singh B, Dayal R, Malik A. Comparison Study of Aloin-Curcumin Nanoparticles by Taking 2 Different Ratios and Analyses by Using Drug Design Experimental Study. International Journal of Drug Delivery Technology. 2024;14(3):1377-1383.

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