International Journal of Drug Delivery Technology
Volume 14, Issue 3

Spectrophotometric Assessment of Pyrocatechol Drug Employing Oxidative Coupling Reaction with 4-amino antipyrine as a Model of Pharmaceutical Compounds

Abbas Fadhil Ali1*, Mustafa Aziz Rahi2, Kamil K Atiyah Altameemi3, Mohammed Kassim Al-hussainawy4, Munthir Abdulwahid Abdulhussain5

1Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq

2Department of Pharmacy, Al-Manara College For Medical Sciences, Maysan, Iraq

3Faculty of Pharmacy, Department of Pharmaceutics, University of Al-Ameed, Karbala, Iraq

4College of Dentist, National University of Science and Technology, Dhi Qar, Iraq

5Department of Pharmacy, Mazaya University College, Iraq 

Received: 27th February, 2024; Revised: 28th May, 2024; Accepted: 24th June, 2024; Available Online: 25th September, 2024

ABSTRACT

A rapid, simple, sensitive, and higher stability spectrophotometric method was developed the determine that it is stable Pyrocatechol drug in pure and pharmaceutical preparations. The method is based on an oxidative coupling reaction among Pyrocatechol drug and 4-amino antipyrine (4AAP) in the presence of potassium iodate (KIO3) in an acid medium to form a color complex that stable violet dye and a maximum absorption at 505 nm. The best optimum conditions and other analytical factors have been evaluated. A calibration curve of absorbance of several concentrations that obey the law of Beer-Lambert over the range concentration of pyrocatechol drug 10 to 100 mg/L, with (LoD =1.2*10-4 mg/L), (LoQ=3.4*10-4 mg/L), The relative standard deviations RSD% of the proposed methods were less than 0.68%). In contrast, recovery average and determination parameters are 99.9%. The method was used successfully for the determination of drugs in a pharmaceutical preparation with the best accuracy and precision. At range about 99.1 to 100.2% with RSD less than 0.3%. The analytical result for the estimation of the pure drug is presented together with the use of the proposed process for the analysis of some commercial pharmaceuticals. The data compare favorably with those of official and reported ways.

Keyword: Spectrophotometric, Determination, Drug, pharmaceutical, pyrocatechol. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.19

How to cite this article: Ali AF, Rahi MA, Altameemi KKA, Al-hussainawy MK, Abdulhussain MA. Spectrophotometric Assessment of Pyrocatechol Drug Employing Oxidative Coupling Reaction with 4-amino antipyrine as a Model of Pharmaceutical Compounds. International Journal of Drug Delivery Technology. 2024;14(3):1384-1388.

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