International Journal of Drug Delivery Technology
Volume 14, Issue 3

Design, Development and Characterization of Gastroretentive Floating Tablet of Levofloxacin using Natural Polymer Peanut Husk

Gyanendra Kumar Saxena*, Ruchi Tiwari

Madhyanchal Professional University, Bhopal, Madhya Pradesh, India. 

Received: 25th March, 2024; Revised: 08th July, 2024; Accepted: 17th August, 2024; Available Online: 25th September, 2024 

ABSTRACT

In the present study, levofloxacin gastroretentive floating tablet (GRFT) was formulated using peanut husk powder as a natural release modifier for providing sustained drug delivery at the stomach to effectively treat infections. Preformulation studies such as UV analysis and drug excipients study using Fourier-transform infrared (FTIR) were performed. Peanut husk powder was prepared by crushing and grinding the dried peanut husk. The GRFT formulations (GRFT1- GRFT9) were formulated using the direct compression method with varied concentrations having peanut husk powder, HPMCK4M and carbapol 934, along with other ingredients. Formulations were characterized based on the pre-compressional parameter and post-compressional parameters. The results for GRFT5 were found to be best among all batches as it showed sustained %drug release of 89.52

± 0.3% upto 12 hours and it revealed enhanced therapeutic performance of the drug. However, in-vivo study needs to be performed for a better comparison of data with in-vitro results.

Keywords: Levofloxacin, Gastroretentive, Floating tablet, Natural, Peanut. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.22

How to cite this article: Saxena GK, Tiwari R. Design, Development and Characterization of Gastroretentive Floating Tablet of Levofloxacin using Natural Polymer Peanut Husk. International Journal of Drug Delivery Technology. 2024;14(3):1404-1407.

REFERENCES

  1. Shahi S, Sonawane A, Vanamore S, Zadbuke Formulation and in-vitro characterization of acyclovir floating matrix tablets: a factorial design study. Journal of Applied Pharmaceutical Science. 2013;3(5):065-74. https://dx.doi.org/10.7324/JAPS.2013.3513
  2. Yadav A, Jain Formulation development and characterization of gastroretentive floating beads. Asian Journal of Pharmacy and Medical Science. 2012;2(1):1-10.
  3. Chauhan S, Tahilani P, Goyanar G, Banweer J. Formulation development and evaluation of Gastroretentive floating tablet of Captopril using natural and synthetic polymer. International Journal of Pharmacy & Life Sciences. 2017;8.
  4. Iglesias N, Galbis E, Romero-Azogil L, Benito E, Lucas R, García- Martín MG, de-Paz In-depth study into polymeric materials in low-density gastroretentive formulations. Pharmaceutics. 2020;12(7):636. https://doi.org/10.3390/pharmaceutics12070636
  5. Baratam SR, Vijayaratna Formulation and evaluation of floating matrix tablets of levofloxacin hemihydrate using hydroxypropyl methylcellulose k4m to treat helicobacter pylori infection. Asian Journal of Pharmaceutical and Clinical Research. 2018;11(6):148-
  6. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.20296
  7. Pandey NK, Ghatuary SK, Dubey A, Jain PK. Formulation and in vitro evaluation of sustained release floating matrix tablet of levofloxacin by direct compression method. Journal of Drug Delivery and 2019;9(4-s):398-403. https://doi.org/10.22270/jddt.v9i4-s.3345
  8. Sharma PK. Development and Evaluation of Fast‑Dissolving Oral Film of Poorly Water-Soluble Drug Felodipine. Asian Journal of Pharmaceutics (AJP). 2018;12(01). https://doi. org/10.22377/ajp.v12i01.2070
  9. Sharma P, Dube B, Sawant Development and evaluation of nanostructured lipid carriers of cytarabine for treatment of meningeal leukemia. Journal of nanoscience and nanotechnology. 2011;11(8):6676-82. https://doi.org/10.1166/jnn.2011.4235
  10. Eswer G, Saritha M. Formulation and evaluation of atenolol floating tablets using different polymers: guargum, sodium alginate, Hpmc100cps and Carbopol940. International Journal of Pharmaceutical & Biological Archives. 2011;2(4):1148.
  11. Sriram P, Suttee A, Marasakatla Z. Formulation and Taste Masking of Metronidazole Oral Disintegrating Tablets by a Novel International Journal of Pharmaceutical Quality Assurance. 2020;11(3):399-403. DOI: 10.25258/ijpqa.11.3.15
  12. Gayakwad BP, Bavaskar SR, Fulzele S, Yadav R, Gauttam V, Sawale J. Design and Development of Captopril Gastro- Retentive Tablet Using Natural Polymers of Maize and Jowar Plant. International Journal of Life science and Pharma 2023;13(12):P1- 6. http://dx.doi.org/10.22376/ ijlpr.2023.13.2.P1-P16
  13. Dhone PG, Sahu YP, Sabitri B, Khandelwal PN. Formulation and evaluation of floating tablet of levofloxacin. International Journal of Health 2022(I):13468-13477. https://dx.doi. org/10.53730/ijhs.v6nS1.8562
  14. Malviya S, Pandepy J, Dwivedi Formulation and evaluation of floating microbeads of Ciprofloxacin HCl by emulsion gelation method. International Journal of Pharmacy & Life Sciences. 2013;4(8): 2876-2884.
  15. Singh C, Yashwant, Gupta Formulation and the Study of Finished Products Used for Anginal Disease. International Journal of Pharmaceutical Quality Assurance. 2022;13(4):385-; DOI: 10.25258/ijpqa.13.4.07
  16. Nikam V, Bhosale Design, Development and Physicochemical Evaluation of Effervescent Tablets of Antihistamine Drug. International Journal of Dr ug Delivery Technology. 2023;13(4):1520-1526. DOI: 10.25258/ijddt.13.4.61
  17. Shkara AM, Ghareeb Formulation and In-vitro Evaluation of Rivaroxaban Tablet by Fused Deposition Modelling 3D Printing Technique. International Journal of Drug Delivery Technology. 2022;12(1):1-11. DOI: 10.25258/ijddt.12.1.00