International Journal of Drug Delivery Technology
Volume 14, Issue 3

Development and Evaluation of Herbal Antiacne Gel Formulation Using Curcumin Phytosomes

Angum MM Ibrahim1*, Siham K AbdelRahim2, Huriyyah A Alturaifi2, Intisar AM Elalawy1

1Al Rayan Private College of Health Sciences and Nursing, Al Madinah Al Munawarah, , Saudi Arabia.

2Department of Chemistry, College of Science, King Khalid University, Abha, Saudia Arabia.

 

Received: 24th February, 2024; Revised: 28th March, 2024; Accepted: 10th August, 2024; Available Online: 25th September, 2024

 

ABSTRACT

Acne vulgaris is a persistent inflammatory condition affecting the pilosebaceous unit that manifests as various skin lesions, including papules, comedones, cysts, pustules, and abscesses. Curcumin, extracted from Curcuma longa rhizomes (Family: Zingiberaceae), is identified for its potent antioxidant, wound-healing, and anti-inflammatory properties. This study aimed to develop an herbal antiacne gel formulation incorporating bioactive curcumin in phytosomes. The formulated gel was evaluated for several physicochemical properties, including pH, spreadability, viscosity, drug content, etc. Additionally, the optimized gel formulation was tested for its in-vitro antiacne action against Propionibacterium acnes. Results showed that developed antiacne gel containing curcumin phytosomes was comparable to a commercially available antiacne product. Stability studies demonstrated that the formulated product remained stable for three months under accelerated stability conditions as per ICH guidelines.

Keywords: Antiacne, Curcumin, Phytosomes, Antioxidant activity, gel.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.26

How to cite this article: Ibrahim AMM, AbdelRahim SK, Alturaifi HA, Elalawy IAM. Development and Evaluation of Herbal Antiacne Gel Formulation Using Curcumin Phytosomes. International Journal of Drug Delivery Technology. 2024;14(3):1435-1440.

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