International Journal of Drug Delivery Technology
Volume 14, Issue 3

Microemulsion Drug Delivery of Anti-malarial

Jaiswal Nilesh*, Mehta Parulben

School of Pharmacy, LNCT University, Bhopal, Madhya Pradesh, India.

Received: 27th February, 2024; Revised: 28th May, 2024; Accepted: 24th June, 2024; Available Online: 25th September, 2024 

ABSTRACT

Malaria affects millions of people every year, especially in our world. The main treatments are oral antibiotics and vaccines. The rise of the malaria parasite, now resistant to most anti-viral drugs, is causing a global crisis. Furthermore, low water solubility and permeability of both new and old antibiotics cause limited oral bioavailability and non-compliance from patients. Lipid formulations are frequently employed to lessen toxicity, boost solubility, and improve effectiveness. The findings of studies on oral-specific lipophilic drug delivery systems, such as self-emulsifying drug delivery systems, are reviewed in this article. (SEDDS). SEDDS increases the absorption of anti-inflammatory drugs by promoting the formation of liquid emulsions that dissolve the drug in the intestine. However, traditionally used SEDDS are usually in liquid form, administered into the oral cavity, and have poor safety. This article discusses a new solidification process that can be easily and economically scaled up by using existing equipment. This strategy might also increase patient compliance and product stability. Oral SEDDS has a substantial potential influence in the fight against malaria.

Keywords: Self-emulsify, Anti-malarials, Lipoidal formulations, Microemulsions, Lymphatic system.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.03

How to cite this article: Nilesh J, Parulben M. Microemulsion Drug Delivery of Anti-malarial. International Journal of Drug Delivery Technology. 2024;14(3):1261-1268.

REFERENCES

  1. WHO’s World Malaria World Health Organization. 2024 Jan p. 322.
  2. Klayman DL. Qinghaosu (artemisinin): An antimalarial drug from China. Science. 1985;228(4703):1049–1055. Available from: org/10.1126/ science.3887571
  3. White NJ, Hien TT, Nosten FH. A Brief History of Qinghaosu. Trends 2015;31(12):607-610. Available from: doi. org/10.1016/j.pt.2015.10.010
  4. Li J, Zhou B. Biological actions of artemisinin: Insights from medicinal chemistry Molecules. 2010;15(3):1378-1397. Available from: doi.org/10.3390/molecules15031378
  5. Sugathan A, Rao S, Kumar NA, Chatterjee PK. Malaria and Malignancies-A Global Biosecurity. 2024;6(1). Available from: doi.org/10.31646/gbio.249
  6. Tan SLJ, Billa N. Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Pharmaceutics. 2021; 13(11):1817. Available from: doi.org/10.3390/ pharmaceutics13111817
  7. Gupta S, Kesarla R, Omri A. Formulation strategies to improve the bioavailability of poorly absorbed drugs with special emphasis on self-emulsifying systems. ISRN Pharmaceutics. 2013; 1(1): 1-16. Available from: org/10.1155/2013/848043
  8. Mukherjee S, Ray S, Thakur RS. Solid lipid nanoparticles: A modern formulation approach in drug delivery system. Indian Journal of Pharmaceutical Sciences. 2009; 71(4): 349-358. Available from: doi.org/10.4103/0250-474X.57282
  9. Peterson B, Weyers M, Steenkamp JH, Steyn JD, Gouws C, Hamman Drug Bioavailability Enhancing Agents of Natural Origin (Bioenhancers) that Modulate Drug Membrane Permeation and Pre-Systemic Metabolism. Pharmaceutics. 2019 ;11(1): 33. Available from: doi.org/ 10.3390/pharmaceutics11010033
  10. Taha E, Ghorab D, Zaghloul AA. Bioavailability assessment of vitamin a self-nano emulsified drug delivery systems in rats: a comparative Medical Principles and Practice. 2007 ;16(5):355-359. Available from: doi.org/10.1159/000104808
  11. Chen ZQ, Liu Y, Zhao Improved oral bioavailability of poorly water-soluble indirubin by a super saturable self microemulsifying drug delivery system. International Journal of Nanomedicine. 2012; 7:1115-1125. Available from: doi. org/10.2147/IJN.S28761
  12. Lawrence MJ, Rees GD. Micro-emulsion-based media as novel drug delivery systems. Advanced Drug Delivery Reviews. 2000;45(1): 89-121. Available from: doi.org/10.1016/S0169- 409X(00)001034
  13. Tang B, Cheng G, Gu JC, Xu CH. Development of solid self- emulsifying drug delivery system; preparation techniques and dosage forms. Drug Discovery Today. 2008; 13:606-612. Available from: doi.org/10.1016/j.drudis.2008.04.006
  14. Zhang P, Liu Y, Xu J. Preparation and evaluation of self- emulsifying drug delivery system of oridonin. International Journal of Pharmaceutics. 2008; 355:269-276. Available from: doi.org/ 10.1016/j. ijpharm.2007.12.026
  15. Tang TT, Hu XB, Liao DH, Liu XY, Xiang DX. Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking International Journal of Nanomedicine. 2013; 8:4415-4426. Available from: doi.org/10.2147/IJN.S51469
  16. Patil R, Kshirsagar Formulation, Optimization and Evaluation of Solid SMEDDS of Itraconazole in Effervescent Granules Form. International Journal of Pharmaceutical Quality Assurance. 2024;15(1):273-287. Available from: doi.org/10.25258/ ijpqa.15.1.42
  17. Arti N, Ravindra K. Formulation and Evaluation of Fenofibrate Dry Emulsion Tablets by Freeze Drying Method. International Journal of Pharmaceutical Quality Assurance. 2022;13(4):369-Available from: doi.org/10.25258/ijpqa.13.4.05
  18. Ellen KG, Mhangoa B, Benjamin R, Bergthora S, Gizurarson Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria. Drug Delivery. 2024; 31 (1):1-10. Available from: doi.org/10.1080/10717544.2023.2299594
  19. Utami1 D, Meliana Y, Budianto E. In-Vitro Dissolution and Characterization of Self-Emulsifying Drug Delivery System of Artemisinin for Oral Delivery. Journal of Physics: Conference Series. 2021; 1811: 1-8. Available from: doi.org/10.1088/1742- 6596/1811/1/012133
  20. Babu AM, Rao PB, Sudhakar Formulation and evaluation of self-microemulsion drug delivery system of low solubility drug “simvastatin” for improved solubility and bioavailability. International Journal of Pharmacy & Therapeutics. 2012: 3(2):189-197. Available from: doi.org/10.21276/ijpt.
  21. Brinkmann J, Exner J, Luebbert C, Sadowski G. In-Silico Screening of Lipid-Based Drug Delivery Systems. Pharmaceutical Research. 2020; 37: 1-12. Available from: org/10.1007/s11095-020-02955-0
  22. Ngawhirunpat T, Worachun N, Opanasopit P, Rojanarata T, Panomsuk S. Cremophor RH40-PEG 400 microemulsions as transdermal drug delivery carrier for Pharmaceutical Development and Technology. 2021; 18 (4): 798–803. Available from: doi.org/10.3109/10837450.2011.627871
  23. Anjana R, Sunil K, Sharma H, Khar RK. Phytosome Drug Delivery of Natural Products: A Promising Technique for Enhancing Bioavailability. International Journal of Drug Delivery 2017; 7(3) :157-165. Available from: doi. org/10.25258/ijddt.v7i03.9559
  24. Rao YS, Deepthi KS, Chowdary Microemulsions: a novel drug carrier system. International Journal of Drug Delivery Technology. 2009; 1(2): 39-41. Available from: doi.org/10.25258/ IJDDT.V1I2.8838