International Journal of Drug Delivery Technology
Volume 14, Issue 3

Synthesis, Spectral Characterization and Biological, DNA Binding, Molecular Docking and ADMET Studies of a New Benzyl (Z)-N’-((E)- 3-Ethoxy-2-Hydroxybenzylidene) Carbamohydrazonothioate and Its Co (II), Ni (II), Cu (II) and Zn (II) Metal Complexes Derived From S-Benzyl Thiosemicabazide-Salicylaldehyde

M Sridhar1,2, P Ramesh3, K Laxma Reddy4, S Durga4, P Muralidhar Reddy4, A Krishnam Raju1*

1Department of Chemistry, University College of Technology Osmania University, Hyderabad, India..

2Department of Chemistry, SRR Govt. Arts & Science College, Karimnagar, India

3Department of Chemistry, S.R&B.G.N.R. Government College (A), Khammam, India

4Department of Chemistry, University College of Science, Osmania University, Hyderabad, India. 

Received: 24th February, 2024; Revised: 28th March, 2024; Accepted: 10th August, 2024; Available Online: 25th September, 2024 

ABSTRACT

This study presents the synthesis, characterization, and biological evaluation of metal complexes derived from benzyl carbamohydrazonothioate. The ligand was synthesized through a condensation reaction and subsequently complexed with various metal ions, including Cu(II), Ni(II), Co(II), and Zn(II). The resulting metal complexes were characterized using a range of spectroscopic techniques, including FT-IR, UV-Vis, and NMR spectroscopy, confirming the successful coordination of the metal ions with the ligand. The structural elucidation was further supported by elemental analysis and molar conductance measurements. The biological activities of the synthesized complexes were evaluated for their antibacterial, antifungal, and antioxidant properties. The results indicated that the metal complexes exhibited enhanced biological activities compared to the free ligand, suggesting their potential as effective antimicrobial and antioxidant agents. This study highlights the significance of metal complexation in enhancing the biological efficacy of organic ligands.

Keywords: Spectroscopic techniques, Antioxidant, Thiosemicarbazide, Schiff base. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.30

How to cite this article: Sridhar M, Ramesh P, Reddy KL, Durga S, Reddy PM, Raju AK. Synthesis, Spectral Characterization and Biological, DNA Binding, Molecular Docking and ADMET Studies of a New Benzyl (Z)-N’-((E)-3-Ethoxy-2- Hydroxybenzylidene) Carbamohydrazonothioate and Its Co (II), Ni (II), Cu (II) and Zn (II) Metal Complexes Derived From S-Benzyl Thiosemicabazide-Salicylaldehyde. International Journal of Drug Delivery Technology. 2024;14(3):1469-1478.

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