International Journal of Drug Delivery Technology
Volume 14, Issue 3

Development and Evaluation of Voriconazole Loaded Transfersomal Gel for Enhanced Antifungal Activity

Amareshwar S1*, Abbaraju Krishna Sailaja2

1Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana, India.

2Department of Pharmaceutics, RBVRR Women’s College of Pharmacy, Osmania University, Hyderabad, Telangana, India. 

Received: 20th January, 2024; Revised: 27th February, 2024; Accepted: 11th July, 2024; Available Online: 25th September,2024 

ABSTRACT

The BCS class II antifungal drug voriconazole (VRC) has a broad spectrum of action. Its solubility is still a major problem for formulation scientists despite numerous attempts to improve it. The thin-film hydration technique produced the voriconazole- loaded Transfersomes, optimized using the Central Composite Design (CCD) and then included as a gel into Poloxamer 407P. Several parameters were assessed for the prepared VRCT, including particle size, zeta potential, surface shape, potential chemical interaction, and polydispersity index (PI). The SEM study also revealed the appearance and surface of optimized transferosomes are symmetrical. The optimized formulation’s average size was found to be 238.8 nm by the particle size analysis. Similarly, a value of 0.449 was found by the polydispersity index (PI). To evaluate voriconazole Transfersomal gel’s (TG4) antibacterial efficacy, an antimicrobial investigation was conducted. The creation of Transfersomal gel formulation offers a topical drug administration method that is more effective and improves patient compliance.

Keywords: Fungal infection, Voriconazole, Transfersomes, gel, Central composite design. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.32

How to cite this article: Amareshwar S, Sailaja AK. Development and Evaluation of Voriconazole Loaded Transfersomal

Gel for Enhanced Antifungal Activity. International Journal of Drug Delivery Technology. 2024;14(3):1487-1494.

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