Formulation Development of Mucoadhesive Vaginal Gel of Secnidazole and Voriconazole

Vaidya VR^1*, Powar PV¹, Pandya SV¹, Yadav VD²

¹Department of Pharmaceutics, Dr. DY Patil College of Pharmacy, Akurdi, Pune, Maharashtra, Pune, India.

²Department of Pharmaceutics, SET’s Arvind Gavali College of Pharmacy, Satara, Maharashtra, India.

Received: 07^th March, 2024; Revised: 04^th May, 2024; Accepted: 15^thJuly, 2024; Available Online: 25^th September, 2024 

ABSTRACT

Purpose: Over the preceding decades, developing conventional drug delivery in to modified form has acquired importance in the pharmaceutical industry. Vaginal drug delivery system offers localized drug administration of drug and also avoids unwanted side effects of oral drug delivery. Vaginal drug delivery system has significant role in medical practice. Even though VDDS has a lot of advantages over the other routes of administration. The goal of developing the Mucoadhesive Vaginal Gel was to achieve the synergistic effect of voriconazole and secnidazole in the treatment of bacterial and fungal vaginal infections.

Method: Mucoadhesive antimicrobial vaginal gel was optimised using Design expert software using Carbopol 934, HPMC K4M polymers.

Result: Formulation was evaluated for various rheological parameters ,antimicrobial activity, invitro drug release and stability study. The spreadability and pH was found to be 5.5 to 7.4 cm and 4.12. Its compatible with vaginal pH. The selected optimized F8 formulation is the best formulation and the drug ratio is 2:1. and optimum gel viscosity is 1874 cps. antimicrobial study revealed that faster drug release of test formulation was compared to marketed product. It indicates as inhibition zone.

Conclusion: The combination of drugs can serves as better option for treating vaginitis, compared to single drug formulation.

Mucoadesion increases contact time of drug with affected area which rendered formulation more effective.

Keywords: Muco-adhesion, Secnidazole, Voriconazole, Vaginal delivery, Vaginitis. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.37

How to cite this article: Vaidya VR, Powar PV, Pandya SV, Yadav VD. Formulation Development of Mucoadhesive Vaginal Gel of Secnidazole and Voriconazole. International Journal of Drug Delivery Technology. 2024;14(3):1521-1525.

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