International Journal of Drug Delivery Technology
Volume 14, Issue 3

Formulation, Development & Evaluation of Mallotus philippensis Extract Loaded NLCS based Nanogel for Psoriasis

Nandini1, Hemant KS Yadav1*, Jasmine2, Sanchit Puniani2

1Department of Pharmaceutics, School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.

2Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India.

Received: 20th January, 2024; Revised: 27th February, 2024; Accepted: 11th July, 2024; Available Online: 25th September, 2024 

ABSTRACT

The current study’s objective was to develop and evaluate the potential of Bergenin-loaded nanostructured lipid carriers (NLCs) as a novel topical therapeutic for psoriasis, obtained from Mallotus philippensis. NLCs loaded with Bergenin were created using a modified Hot-melt emulsification technique, and then Box-Behnken design optimization was performed. The Independent factors were concentration of solid lipid, the concentration of liquid lipid and the concentration of surfactant. Particle size, entrapment efficiency, and drug permeation percentage were the dependent variables. The Bergenin-nano-lipid carriers (NLCs) that has been optimized has a Particle size of 148 ± 0.37 nm, an %Entrapment efficiency of 93.44 ± 0.45%, and a drug permeation percentage was found to be 83.56 ± 0.137. and the zeta potential was - 0.0617 ± 5.53 mV and the polydispersity index (PDI) was 0.30 ± 0.03. Bergenin’s existence within the NLCs was verified by FTIR. The outcomes show that Nanostructured lipid carriers have the ability to deliver Bergenin for topical psoriasis treatment.

Keywords: Psoriasis, NLCs, Bergenin, Mallotus philippensis, %Entrapment efficiency, Particle size, Polydispersity index,Zeta Potential.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.04

How to cite this article: Nandini, Yadav HKS, Jasmine, Punianib S. Formulation, Development & Evaluation of Mallotus philippensis Extract Loaded NLCS based Nanogel for Psoriasis. International Journal of Drug Delivery Technology. 2024;14(3):1269-1277.

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