International Journal of Drug Delivery Technology
Volume 14, Issue 3

Design, Devlopment and Evaluation of Gastroretentive Floating Microspheres of Glibenclamide: In-vitro In-vivo Studies

Radheshyam Samanta1*, Gaurav Tiwari1, Naveen Gupta1, Dharmendra Singh Rajput1 Prasenjit Maity2

1Department of Pharmacy, Patel College of Pharmacy, Madhyanchal Professional University, Bhopal, Madhya Pradesh, India.

2Department of Pharmaceutical Science and Technology, BIT MESRA, Ranchi, Jharkhand, India. 

Received: 15th March, 2024; Revised: 23rd May, 2024; Accepted: 13th August, 2024; Available Online: 25th September, 2024 

ABSTRACT

The current research study was designed to characterize the ethyl cellulose act as a carrier mediator used to prepare a floating microsphere of glibenclamide for developed gastroretentive sustain release floating drug delivery. Different microspheres of glibenclamide were formulated by the emulsion solvent evaporation technique of glibenclamide with EC in different ratios by using two solvent systems (ethanol and chloroform). After evaluating the micropolitics properties, %of yield value, drug loading efficiency, entrapment efficiency, diameter and surface morphology of the microsphere by using DLS and SEM, in-vitro drug release in gastric content, in-vitro buoyancy, and in-vivo floatation using animal model, compatibility study by FTIR, DSC and any other analytical study to demonstrate all formulation (especially GM2) was showing excellent results. So this work shows great gastro etentive floating drug delivery system for prolonged periods of time which is very useful in future for further study.

Keywords: Gastroretentive, Solvent evaporation, Floatation, Microspheres. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.48

How to cite this article: Samanta R, Tiwari G, Gupta N, Rajput DS, Maity P. Design, Devlopment and Evaluation of Gastroretentive Floating Microspheres of Glibenclamide: In-vitro In-vivo Studies. International Journal of Drug Delivery Technology. 2024;14(3):1591-1598.

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