International Journal of Drug Delivery Technology
Volume 14, Issue 3

Nanoemulsion of Ethanolic Extract of Sungkai Leaves (Peronema Canescens Jack) for Anti-Acne Therapy

Witha Budiartina, Winda Putria Sari, Ali Napiah Nasution, Ermi Girsang*

Department of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, Indonesia. 

Received: 24th February, 2024; Revised: 28th March, 2024; Accepted: 10th August, 2024; Available Online: 25th September, 2024 

ABSTRACT

This study investigates the phytochemical profile, total flavonoid content, antibacterial properties, antioxidant activities, and cytotoxicity effect of nanoemulsion ethanolic extract of Sungkai leaves. The ethanolic extract was formulated into three concentrations: 50, 100, and 150 ppm. Phytochemical screening revealed flavonoids, tannins, alkaloids, steroids, and terpenoids. The total flavonoid content was 90.542, 91.993, and 91.744% for the respective concentrations. Antibacterial activity against Propionibacterium acnes showed inhibition zones of 17.6, 21.2, and 24.1 mm, indicating strong to very strong activity. Antioxidant activities, evaluated using DPPH, ABTS, and FRAP assays, showed IC50 values categorized as very strong. The cytotoxicity test exhibited moderate activity. These findings suggest that Sungkai leaf ethanol extract nanoemulsion has rich bioactive compounds with significant antibacterial and antioxidant properties, along with moderate cytotoxic activity, highlighting its potential for pharmaceutical and cosmetic applications.

Keywords: Sungkai leaves, Nanoemulsion, Flavonoid, Antibacterial, Antioxidant, Cytotoxicity. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.50

How to cite this article: Budiartina W, Sari WP, Nasution AN, Girsang E. Nanoemulsion of Ethanolic Extract of Sungkai Leaves (Peronema Canescens Jack) forAnti-Acne Therapy. International Journal of Drug DeliveryTechnology. 2024;14(3):1604-1610.

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