International Journal of Drug Delivery Technology
Volume 14, Issue 3

Experimental Antioxidant Activities of Synthetic 3,4-Dihydropyrimidine Derivatives

Mahmood S. Magtoof1*, Noor R Ali1, Rabeah T Mahmood2

1Department of Chemistry, Science College, Thi-Qar University, Iraq.

2Department of Applied Chemistry, Applied Sciences College, Samarra University, Iraq. 

Received: 20th February, 2024; Revised: 27th March, 2024; Accepted: 05th August, 2024; Available Online: 25th September, 2024 

ABSTRACT

The synthesized of five new pyrimidine derivatives was prepared from the condensation in one pot reaction of ethyl acetoacetate, substituted aromatic aldehydes, urea, and FeCL3.6H2O, with 5 to 10 drops of hydrochloride acid as catalyst in reflexing ethanol. The yield of the product was found to be in the range of 55 to 90%. The antioxidant efficiency of synthesized compounds was estimated by using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method, hydroxyl method, nitric oxide method, and superoxide radical scavenging assay method. The compounds 6a, 6e, and 6c demonstrated considerable radical scavenging activity, resulting in the presence of electron-donating substituent on replaced aldehydes. The confirmation compounds by spectral data by proton and 13C-nuclear magnetic resonance, infrared spectra, and MS spectra.

Keywords: One-pot reaction, dihydropyrimidines, DHPMs, Antioxidant.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.55

How to cite this article: Magtoof MS, Ali NR,  Mahmood RT. Experimental Antioxidant Activities of Synthetic 3,4-Dihydropyrimidine Derivatives. International Journal of Drug Delivery Technology. 2024;14(3):1641-1643.

REFERENCES

  1. Patel DH, Mistry BD, Desai KR. Synthesis and antimicrobial activity of pyrazolo[3,4-d]pyrimidines. Indian J Hetero Chem. 2003;13:179–80.
  2. Kazhal Z, Milad P, Zahra O, Surfactant TBAB as a Catalyst for the synthesis of 3, 4-Dihydropyrimidine Derivatives J. Synth. Chem. 2024, 3, 49-60.
  3. Shan KK, Gupta GP, Singh Synthesis of novel pyrimidinediones and thiazolidinediones as cardiovascular agents. Indian J Chem. 1985; 24: 1094–7.
  4. Lather V, Chowdary Synthesis and antimicrobial activity of N1(arylidine hydrazidomethyl)-indoles,2-(substituted aryl)-3- (N1-indolyl acetamidyl)-4-oxo-thiazolidines and 5-benzylidine derivatives of thiazolidinones. Indian J Pharm Sci. 2003;65:576–9.
  5. G a d a g i n a m a t h GS , Shya d l ige r i A S , K ava l i R R . Chemoselectivity of indole-dicarboxylates towards hydrazine hydrate: part III-synthesis and antimicrobial activity of novel 4-thiazolidinonylindoles.
  6. Renukadevi P, Biradar Synthesis and antimicrobial activity of 3,5-disubstituted-2-[1′-phenyl-5′-thioalkyl-s-triazol-2′-yl]indoles and 3,5-disubstituted-2-[1′-substituted aminomethyl-4′-phenyl- 5′,4′-phenyl-5′(4′H)-thion-s-triazol-3-yl]indoles. Indian J Hetero Chem. 1999; 9: 107–12.
  7. Klohr SE, Cassady An intramolecular photocyclization to form the azepino[3,4,5- cd]indole system. Synthetic Communication. 1988; 18: 671
  8. Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in the hind paw of the rat as an assay for antiinflammatory Proc Soc Exp Biol. 1962; 111: 544–7 ]
  9. Newbould Chemotherapy of arthritis induced in rats bymycobacterial adjuvant. Brit J Pharmacol. 1963; 21: 127–36.
  10. Seeley HW, Van Denmark Microbes in action: A laboratory manual of microbiology. Mumbai: D B Taraporevala Sons and Co Pvt Ltd; 1975. [
  11. Kavanagh F. Analytical microbiology. N ew York: 1 963. p p. 313–46.
  12. Russowsky D, Canto RFS, Sanches SAA, D’Oca MGM, de Fátima A, Pilli RA, Kohn LK, De Antônio MA, Carvalho J. Bioorganic Chemistry, 34:173–182, 2006.
  13. Lewis RW, Mabry J, Polisar JG, Eagen KP, Ganem B, HessBiochemistry, 49. 4841, 2010.
  14. Sadeghpour H, Miri R, Ebadi SA, Mohammad, Shima, Riazimontazer Trends in Pharmaceutical Sciences, 2023, Vol 9, Issue 3, p191.