International Journal of Drug Delivery Technology
Volume 14, Issue 3

Box-Behnken Design Optimization of Captopril-Loaded Transferosomes: Formulation and Characterization

Ismail Y1, Mrunalini Harish Kulkarni2*, Yamjala Ganesh Kumar3, G Dharmamoorthy4

1Crescent School of Pharmacy, B.S.Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, India.

2School of Pharmacy, Vishwakarma University, Kondhwa,Pune, India.

3Sree Dattha Institute of Pharmacy, Department of Pharmacognosy & Phytochemistry, Sheriguda, Ibrahimpatnam, Rangareddy, Telangana, India.

4Dept. of Pharmaceutical Analysis, MB School of pharmaceutical sciences (Erstwhile Sree Vidyanikethan college of pharmacy), Mohan Babu University, Rangampeta, Tirupati, Andhra Pradesh, India.

Received: 16th March, 2024; Revised: 23rd May, 2024; Accepted: 02nd August, 2024; Available Online: 25th September, 2024

ABSTRACT

This study aimed to overcome the limitations of oral delivery and enhance the permeation of Captopril (CPL) by developing transferosomes. Transferosomes encapsulating CPL were prepared using a thin film hydration method. Seventeen formulations were prepared, varying Soya lecithin, Tween-20, and sonication speed. The formulations were evaluated for vesicle size (VS), polydispersity index (PDI), and entrapment efficiency (EE%). The optimized formulation’s discharge profile was compared with that of the CPL suspension. Transferosomes exhibited VS ranging from 244 to 376 nm and EE% from 65 to 91%, with zeta potentials ranging from -51 to -26 MV. In-vitro and ex-vivo permeation studies demonstrated superior drug permeation for transferosomal formulations compared to plain CPL suspension. CPL transferosomes represent a promising delivery system for prolonged and controlled drug discharge, offering potential improvements in hypertension management.

Keywords: Captopril, Drug permeation, Delivery, Transdermal, Transferosomes. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.06

How to cite this article: Ismail Y, Kulkarni MH, Kumar YG, Dharmamoorthy G. Box-Behnken Design Optimization of Captopril-Loaded Transferosomes: Formulation and Characterization. International Journal of Drug Delivery Technology. 2024;14(3):1292-1298.

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