International Journal of Drug Delivery Technology
Volume 14, Issue 3

New Metal Complexes with Mannich -β-amino carbonyl ligand; Preparation, spectral Characterisation and Biological Activity

Baraa Kasim Mohammed, Enaam Ismail Yousif*

Department of Chemistry, College of Education for Pure Science (Ibn Al-Haitham), University of Baghdad, Adhamiyah, Baghdad, Iraq. 

Received: 15th March, 2024; Revised: 23rd May, 2024; Accepted: 13th August, 2024; Available Online: 25th September, 2024 

ABSTRACT

New metal complexes and a new beta-amino maniche carbonyl ligand were prepared and characterized. (((4-(tert-butyl)-2-((S)- (phenylamino) (p-tolyl) methyl)cyclohexan-1-one)) (HL) was formed from the reaction of aniline and 4-methylbesaldehyde with 4- (tert-butyl)cyclohexane-1-one at a 1:1:1 mol ratio respectively reaction of (4-methyl-2-((R)-(phenylamino)(p-tolyl) methyl)cyclohexan-1-one (HL) and MnII, CoII, NiII, CuII, ZnII and CdII metal ions in a 2:1 (L:M) ratio led to the isolation of monomeric complexes from analytical and spectroscopic techniques including; elemental microanalysis, magnetic susceptibility, conductivity, TGA, and FTIR, electronic and mass spectra and 1H, 13C-NMR characterization data indicated to a four- and six-coordinate isolate.Complexes Many bacterial and fungal strains were tested, and the data obtained showed that these complexes are more active against a variety of organisms, under experiment, than free associations.

Keywords: 4-(tert-butyl)cyclohexan-1-one, β-amino carbonyl, Thermal analysis, Candida and Rhizopus porium, Metal Complexes.

International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.3.60

How to cite this article: Mohammed BK, Yousif EI. New Metal Complexes with Mannich -β-amino carbonyl ligand; Preparation, spectral Characterisation and Biological Activity. International Journal of Drug Delivery Technology. 2024;14(3):1676-1682.

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